In vitro fertilization and Vitamin D – many studies
Note: This page needs to be merged with IVF 4X more successful for white women with lots of vitamin D – many studies
IVF newborns had ~2 ng/mL higher Vitamin D levels - April 2024
Vitamin D3 among neonates born after in vitro fertilization compared with neonates from the general population
Acta Obstet Gynecol Scand. 2024;00:1–10. DOI: 10.1111/aogs.14819
Karen Christina Walker1© | Sofie Gry Pristed2,3 | Fanney Thorsteinsdottir1,4 Ina Olmer Specht1,4© | Arieh Cohen5 | Berit Lilienthal Heitmann 1,3,6© |
Ulrik Schi0ler Kesmodel 2,7
Introduction: Sufficient levels of vitamin D have been associated with higher chances for both clinical pregnancy and live birth among women undergoing assisted reproductive techniques, whereas low levels of maternal vitamin D have been associated with preeclampsia and late miscarriage. In Denmark, subgroups at risk for low vitamin D levels, including neonates and toddlers, are recommended to use supplementation. The aim was to study the level of vitamin D3 among neonates born after in vitro fertilization compared with neonates from the general population.
Material and methods: In this cohort study a random sample of 1326 neonates representing the general population and 1200 neonates conceived by in vitro fertilization born in Denmark from 1995 to 2002 were identified from registries covering the whole Danish population. Information on use of assisted reproduction was collected from the Danish In Vitro Fertilization register, ICD-10 code: DZ358F. 25-Hydroxyvitamin D was measured from dried blood spots routinely collected by heel prick 48-72h after birth and corrected according to the hematocrit fraction for capillary blood of neonates. Linear regression analysis was performed, both crude and adjusted, for predefined putative confounders, identified through directed acyclic graphs.
Results: Vitamin D3 analysis could be performed from a total of 1105 neonates from the general population and 1072 neonates conceived by in vitro fertilization that were subsequently included in the study. The median vitamin D3 was 24.0 nmol/L (interquartile range [IQR] 14.1-39.3) and 33.0nmol/L (IQR 21.3-48.8) among neonates from the general population and neonates conceived by in vitro fertilization, respectively. The adjusted mean difference between neonates from the general population and those conceived by in vitro fertilization was 6.1 nmol/L (95% confidence interval 4.1–8.1)
Conclusions: In this study, children born after in vitro fertilization have a higher vitamin D3 than a random sample of neonates in Denmark.1
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Note: Vitamin D is often given both before and during IVF treatment
I suspect that many of the women (who could afford IVF in the first place) also continue on with the Vitamin D during pregnancy
Note: IVF facilities would probably lose business if they mentioned the huge fertility benefit of Vitamin D
In-vitro Fertilization costs at least 10,000 dollars, Vitamin D costs 5 dollars
IVF success rates greatly increased if added both Vitamin D and Vaginal Probiotics - RCT Feb 2025
The effect of vitamin D supplementation and vaginal probiotics on fertility in women with recurrent implantation failure: A randomized clinical trial
Hum Immunol . 2025 Feb 15;86(3):111259. doi: 10.1016/j.humimm.2025.111259 Vitamin D dose is behind a $28 paywall
Elham Badihi 1, Parisa Sharifi 2, Amir Moradi 3, Amin Kamrani 4, Ali Hassanzadeh 5, Mohammad Sadegh Soltani-Zangbar 4, Sara Parsania 1, Farshid Afandideh 1, Javad Ahmadian Heris 6, Shahla Danaii 7, Behnam Shahriar 1, Mehrin Sadough 1, Forough Chakari-Khiavi 1, Shirin Teymouri Nobari 8, Leili Aghebati-Maleki 1, Mehdi Yousefi 9
Recurrent implantation failure (RIF) is a significant obstacle in assisted reproductive technology, affecting approximately 10 % of couples undergoing in vitro fertilization (IVF). Emerging evidence suggests that vaginal probiotics and vitamin D supplementation may improve reproductive outcomes. This randomized clinical trial evaluated the effects of these interventions on fertility in women with RIF and thin endometrium (<6 mm). A total of 112 women with a history of RIF were randomized into four groups: vaginal probiotics, vitamin D supplementation, a combination of both, or standard IVF treatment (control). The primary outcome was the pregnancy rate, confirmed by β-hCG testing and ultrasound. Secondary outcomes included changes in Th1/Th2 ratio, natural killer (NK) cell activity, and cytokine profiles.
The combination group demonstrated the highest pregnancy rate (46.4 %), which was significantly higher compared with the
probiotics (14.2 %), p = 0.008),
vitamin D (17.8 %), p = 0.002), and control groups (10.7 %), p = 0.003).
Only the combination therapy significantly reduced the Th1/Th2 ratio (p < 0.001) and NK cell activity (p < 0.001), while significantly increasing IL-4 and TGF-β and decreasing IFN-γ levels (all p < 0.001). These findings suggest that combined vaginal probiotics and vitamin D supplementation may improve pregnancy outcomes by modulating the immune responses in women with RIF. This dual intervention may represent a promising strategy for enhancing fertility in this population of RIF patients.
18+ Vitamin D Life pages have IVF or IN VITRO FERTILIZATION etc. in the title
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Vitamin D Life – Vitamin D greatly improves Fertility
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Fertility improved the most if give Vitamin D AND 1 or more Vitamin D Receptor Activators
For male and female before pregnancy
Perhaps 50,000 IU bi-weekly for several months before becoming pregnant
Daily supplement to activate the Vitamin D Receptor
Female to continue with both D and activator thru 6 months after birth
Vitamin D Life – 50,000 IU of Vitamin D - many studies
Vitamin D Life - Vitamin D Receptor activation can be increased in many ways
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Vitamin D Life - studies in both categories Pregnancy and Vitamin D Receptor
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Vitamin D Life - studies in both categories Fertility and Vitamin D Receptor
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