Immunodeficiencies appear to be treated by active Vitamin D (Calcitriol) - Feb 2026
The Immunological Role of Vitamin D in Primary Immunodeficiencies: A Narrative Review of the Current Literature
https://doi.org/10.3390/biomedicines14020303
Emanuela Zumbo 1,+, Federica Nuccio 1,+©, Francesca Paladin 2, Giuseppe Murdaca 3'4'* and Sebastiano Gangemi1 (Italy)
Vitamin D is a fat-soluble hormone essential for bone mineralization. In addition to this role, vitamin D is known for its immunomodulatory effects through its binding to intracellular vitamin D receptors (VDRs), which translocate to the nucleus of immune cells, including antigen-presenting cells (APC), B lymphocytes, T lymphocytes and monocytes, thereby modulating the transcription of genes responsible for the immune response. Vitamin D deficiency is associated with an increased risk of developing infections and autoimmune diseases.
The purpose of this review is to evaluate vitamin D deficiency in patients with primary immunodeficiency (CVID, XLA, DGS, APECED, SCID, WAS, HIES), to assess its clinical and therapeutic impact.
Vitamin D deficiency, often asymptomatic, is associated with more severe clinical conditions in subjects with PID. It can be associated with osteoporosis, fractures, myelofibrosis and endocrine disorders such as hypocalcemia.
These patients responded beneficially to calcitriol therapy, underscoring the need for long-term monitoring.
Highlights from PDF
- Asymptomatic hypovitaminosis D in CVID may increase the risk of developing complications, such as osteoporosis, infections, autoimmune diseases and neoplastic diseases (already known complications).
- VD is a modifiable factor that plays a multifactorial role in DiGeorge syndrome: therapeutic supplementation strategies should be considered to prevent both metabolic and autoimmune complications, such as hypocalcemia, and recurrent infections.
- In APECED, VD could represent a relevant therapeutic target having an influence both on mineral homeostasis induced by hypoparathyroidism and on immune dysregulation.
- A causal link between VD and combined immunodeficiencies has not been reported, but VD supplementation may help prevent/correct some complications of these pathologies.
Related in Vitamin D Life
- What causes a person to be immunocompromized
- Vitamin D and Aging: Central Role of Immunocompetence – Carlberg
- Some immunodeficiency diseases associated with low vitamin D and increased Osteoporosis
- Immunologic Effects of Vitamin D on Human Health and Disease - Holick
- 2260 diseases found to be fought by fully-activated Vitamin D (Calcitriol)
- Calcitriol
There are many ways to get Vitamin D to cells, even if poor liver or kidney or gut without supplementing with Calcitriol. Topical Vitamin D, Gut-Friendly Vitamin D, etc.