IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D

Vitamin D Deficiency Associated with Disease Activity in Patients with Inflammatory Bowel Diseases.

Dig Dis Sci. 2015 Jun 2. https://doi.org/10.1007/s10620-015-3727-4

Torki M1, Gholamrezaei A, Mirbagher L, Danesh M, Kheiri S, Emami MH

1Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran, [email protected].

BACKGROUND:

Evidence exists on the association between vitamin D deficiency and inflammatory bowel diseases (IBD).

AIMS:

To investigate whether vitamin D level is associated with disease activity and quality of life in IBD patients.

METHODS:

This cross-sectional study was conducted on known adult IBD patients referred to an outpatient clinic of gastroenterology in Isfahan city, Iran. Disease activity was evaluated using the Simplified Crohn's Disease Activity Index and Simple Clinical Colitis Activity Index. Quality of life was assessed with the Short-Inflammatory Bowel Disease Questionnaire. Serum 25[OH]D was measured using the radioimmunoassay method. Vitamin D deficiency and insufficiency were defined as concentration of <50 and 50-75 nmol/L, respectively.

RESULTS:

Studied subjects were 85 ulcerative colitis and 48 Crohn's disease patients (54.1 % females) with mean age of 42.0 ± 14.0 years. Vitamin D deficiency and insufficiency were present in 52 (39.0 %) and 24 (18.0 %) patients, respectively. Thirty patients (22.5 %) had active disease who, compared with patients in remission, had more frequent low vitamin D levels (80 vs. 50.4 %, P = 0.005). Quality of life was not different between patients with low and those with normal vitamin D levels (P = 0.693). In the logistic regression model, low vitamin D was independently associated with active disease status, OR (95 % CI) = 5.959 (1.695-20.952).

CONCLUSIONS:

We found an association between vitamin D deficiency/insufficiency and disease activity in IBD patients. Prospective cohorts and clinical trials are required to clarify the role of vitamin D deficiency and its treatment in clinical course of IBD.

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Note: My spouse has very successfully used a nanoemulsion vitamin D to treat her colitis

She had severe attacks of ulcerative colitis many times a year for many decades

Adding oral vitamin D did not appear to help

Previously we had great success applying vitamin D directly to a problem

    gums, warts, burns, abrasions, etc.

We evolved ways to get vitamin d directly to this problem

Vitamin D powder added to water helped some when a teaspoon of it was inserted into the rectum

Adding salt to the water helped

100,0000 IU of nanoemulsion also was good

Ended up using 200,000 IU of nanoemulsion vitamin D in 1 pint of water with a "pinch" of - using about a tablespoon at a time

Similar attack frequency, but far less intense.

The problem goes away after 3 nightly applications

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