Health problems that run in families are often associated with low vitamin D

Created March 2016

"A particular disorder might be described as “running in a family” if more than one person in the family has the condition. Some disorders that affect multiple family members are caused by gene mutations, which can be inherited (passed down from parent to child)." Google

Vitamin D Life realization

  • If a single disease runs in the family it is possible that it is due to a vitamin D gene problem

  • If multiple diseases occur in the family is it likely that they are due to a vitamin D gene problem

Every single health problem in this list is strongly related to vitamin D deficiency.

I have noticed that many of the health problems prevented/treated by vitamin D seem to run in families.

Here is the first list which I found in Google on family related diseases from The National Institute of Health (US).

**
::Health problem
that runs in family::		 ::Vitamin D Life::
alzheimer's/dementia Alzheimers
arthritis Rheumatoid Arthritis
asthma Asthma
blood clots Blood clotting
cancer Cancer
depression Depression
diabetes Diabetes
heart disease Cardiovascular
high cholesterol Cholesterol
high blood pressure Hypertension
pregnancy losses
& birth defects		 Pregnancy
stroke Stroke **

Genes can make the body less efficient at getting vitamin D to the cells.

  • 2 genes have effects which CAN be detected by vitamin D blood tests.

  • 4 genes have effects which CANNOT be detected by vitamin D blood tests.

  • In either case, if a vitamin D deficiency disease runs in your family you will need more vitamin D than the general population.

    • Depending on the gene and the disease, you will need 10% to perhaps 200% larger dose of vitamin D to cancel the gene problem.
    • Unknowns
    • How much more if one specific health problem runs in the family
    • How much more vitamin D if several health problems run in the family

Gene studies in Vitamin D Life

Vitamin D Receptor

{include}

Gene studies of health problems which run in families

Gene studies of other health problems in Vitamin D Life

Also associated with many of the same diseases: Magnesium, Omega-3

Magnesium     Omega-3

The items in both categories of Magnesium and Omega:

{category}

See also heritability on Vitamin D Life

Studies which are in both the GENE and Disease categories

Rheumatoid Arthritis

{category}

Cancer (not specific cancer category)

{category}

Diabetes

{category}

Cardiovascular

{category}

Hypertension

{category}

Pregnancy

{category}

Stroke

{category}

Studies which are in both the Vitamin D Receptor and Disease categories

Rheumatoid Arthritis

{category}

Cancer (not specific cancer category)

{category}

Diabetes

{category}

Cardiovascular

{category}

Hypertension

{category}

Pregnancy

{category}

Stroke

{category}

See also web

  • Diseases that run in families not all down to genes, study shows July 2016
    • ". . examined the medical histories of more than 500,000 people and their families -- including both blood and adoptive relatives."
    • . .They looked at incidents of 12 common diseases including high blood pressure, heart disease, and several cancers and neurological diseases."
    • "By not accounting for shared environmental factors, scientists may overestimate the importance of genetic variation by an average of 47 per cent, the study found"
  • Fact Sheet: Family History is Important for Health CDC Key Features Dec 2015
    • Diseases that occur at an earlier age than expected (10 to 20 years before most people get the disease);
    • Disease in more than one close relative;
    • Disease that does not usually affect a certain gender (for example, breast cancer in a male);
    • Certain combinations of diseases within a family (for example, breast and ovarian cancer, or heart disease and diabetes).
  • Have You Inherited a Vitamin D Deficiency?
    • Jan 2016 Susan Rex Ryan

Autoimmune Disease Clusters - which run in families

image

Figure 8 Familial autoimmunity. The vertical axis corresponds to the proband’s disease and each disease individually. In the horizontal axis diseases present in first degree relatives are shown. Each color belongs to the proband’s disease. The figure only includes significant results and may serve as a guide for clinical practice in order to search ADs in FDRs of probands. Note that familial autoimmune disease is excluded.

AA, alopecia areata; AdD, Addison’s disease; AS, ankylosing spondylitis; AITD, autoimmune thyroid disease; CD, celiac disease; CrD, Crohn’s disease; FDR, first degree relative; IBD, inflammatory bowel disease; IIM, idiopathic inflammatory myositis; JDM, juvenile dermatomyositis; JRA, juvenilerheumatoid arthritis; JSLE, juvenile systemic lupus erythematosus; MAS, multiple autoimmune syndrome; MG, myasthenia gravis; MS, multiple sclerosis; PA, pernicious anemia; PAN, polyarteritis nodosa; PBC, primary biliary cirrhosis; PSO, psoriasis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; SS, Sjögren’s syndrome; SSc, systemic sclerosis; T1D, type 1 diabetes; UC, ulcerative colitis; VIT, vitiligo; WG, Wegener’s granulomatosis.

This study was cited by 57 other publications in Google Scholar as of July 2016 such as:

  • Hashimoto thyroiditis: clinical and diagnostic criteria

  • Diagnosis and classification of autoimmune diabetes mellitus

  • Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE

  • Systemic sclerosis at the crossroad of polyautoimmunity

  • New insights into an autoimmune mechanism, pharmacological treatment and relationship between multiple sclerosis and inflammatory bowel disease

  • The diagnosis and clinical significance of polyautoimmunity

  • Is narcolepsy a classical autoimmune disease?

  • Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM)

  • Identification of a new disease cluster of pemphigus vulgaris with autoimmune thyroid disease, rheumatoid arthritis, and type I diabetes

More on this topic at Autoimmune disease clusters run in families (polyautoimmunity) are associated with low vitamin D

Tags: Genetics Health Problem Vit D Binding Protein Vit D Receptor