Gout and Vitamin D - many studies
12 Reasons to believe that Gout is associated with low vitamin D
Reasons to believe that Gout is associated with low vitamin D
- Acute gouty arthritis is seasonal. 1998
- Increased by 32% in Spring (when vitamin D levels are the lowest)
- Clinical Trials for Gout and Vitamin D
- Study of Vitamin D and Uric Acid Lowering on Kidney and Blood Vessel Function
- Good: 50,000 IU weekly, unfortunately: D2, not D3
Vitamin D reduces Rheumatoid arthritis items
Vitamin D reduces Pain items
Vitamin D reduces Inflammation category listing with items
Higher incidence of gout with age (less vitamin D and gastric acid as you get older)
Increased gout at higher Latitude (Gout and Goutiness a 1899 book
Increased gout with soda pop
- JAMA study from 2010.2 women >2 cans of soda daily 2X more likely to develop gout (Note that soda decreases vitamin D levels)
- 2X more Gout if Dark Skin
- WikiPedia gout is twice as likely in African American males as it is in European Americans
- Gout and Calcium and vitamin D
- Calcium and Vitamin D. The relationship of gout to calcium and vitamin D is complex.
- Gout is associated with insulin resistance, low vitamin D levels, and inflammation, all of which interfere with muscle synthesis.
- One study has found that patients with gout have lower vitamin D3 levels correlated with higher urate.
- Increased gout recently (along with increased number of people being vitamin D deficient)- both blacks and whites
- New Zealand 2009 publication
- Gout incidence has been increasing (while vitamin D has been decreasing)
- Gout has increased, but appears to be correlated with obesity/ hypertension 2011
- note: both obesity and hypertension are associated with low vitamin D
Vitamin D and Gout - includes 2 treatment studies using 50,000 IU weekly or twice a week for 2 months - Sept 2023
Table of Contents
The Link Between Vitamin D and Gout
Vitamin D Deficiency Increases Gout Risk
Can Vitamin D Supplements Help Treat Gout?
How Does Vitamin D Affect Uric Acid Levels?
Uric Acid Production
Uric Acid Excretion
Gut Microbiome Effects
Factors That Can Cause Vitamin D Deficiency
Optimizing Vitamin D Levels to Help Prevent Gout
Key Takeaways: Can Vitamin D Cause Gout?
What is gout?
What causes high uric acid levels?
How is gout diagnosed?
What is the link between vitamin D and gout?
How does vitamin D affect uric acid levels?
Can vitamin D supplements help treat gout?
What causes vitamin D deficiency?
How can I optimize vitamin D levels?
Should I have my vitamin D levels checked?
What is the recommended daily intake of vitamin D?
Are there risks with excessive vitamin D intake?
What other lifestyle measures can help prevent gout attacks?
Note: Perplexity AI was unable to find links to the referenced studies
Note: Topical Vitamin D usually works much better than oral when the problem is near the skin
4X less likely to die of Gout if 40 ng of Vitamin D - Aug 2024
Association of serum 25-hydroxyvitamin D concentrations with all-cause and cause-specific mortality among individuals with gout and hyperuricemia
Nutrition Journal Volume 23, article number 89, https://doi.org/10.1186/s12937-024-00992-8
Ke Liu, Xuanni Lu, Anqi Wang, Weiwei Chen, Ying Chen, Jiayu Li, Xiaohui Sun, Lin Huang, Zhixing He, Chengping Wen, Yingying Mao & Ding Ye
Background
We aimed to probe the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-cause and cause-specific mortality among patients with gout and hyperuricemia (HUA).
Methods
The study included 1169 gout patients and 7029 HUA patients from the National Health and Nutrition Examination Survey (NHANES) 2007–2018 and 2001–2018, respectively. The association between serum 25(OH)D and mortality was evaluated by Cox proportional hazard and restricted cubic spline models.
Results
Among participants with gout and HUA, the weighted mean concentrations of serum 25(OH)D were 71.49 ± 30.09 nmol/L and 64.81 ± 26.92 nmol/L, respectively. Vitamin D deficiency occurred in 29.68% of gout patients and 37.83% of HUA patients.
During 6783 person-years of follow-up among gout patients, 248 all-cause deaths occurred, among which 76 died from cardiovascular disease (CVD) and 49 died from cancer.
1375 HUA patients were recorded for all-cause mortality during 59,859 person-years of follow-up, including 427 CVD deaths and 232 cancer deaths.
After multifactorial adjustment, per one-unit increment in natural log-transformed 25(OH)D was associated with lower risk of 55% all-cause mortality and 61% CVD mortality among gout patients, and a 45% reduced risk of cancer mortality among HUA patients.
Restricted cubic splines showed a U-shaped relationship with all-cause and CVD mortality among HUA patients, with inflection points of 72.7 nmol/L and 38.0 nmol/L, respectively. The results were robust in subgroup and sensitivity analyses.
Conclusions
Serum 25(OH)D was negatively linearly correlated with mortality among gout patients, whereas U-shaped correlated with mortality in HUA patients. These results indicate that adequate vitamin D status could prevent premature death.
📄 Download the PDF from Vitamin D Life
Vitamin D and Gout: Facts, etc.
FACT: Gout increases with age
FACT: Gastric Acid/digestion decreases with age
FACT: Coffee increases gastric acid
FACT: Coffee decreases gout (known since 1672)
FACT: Vitamin D increased digestion
FACT: Vitamin D decreases Gout
CONCLUSION: Improved digestion ==> reduced gout
Hypothesis: Other ways to Increase digestion, such as HCL or digestive enzymes, will also decrease gout
Note: Vitamin D reduces gout by at least the following ways:
improving digestion
- Gastic acid decreases with age has the following chart
More Uric acid (from incomplete digestion of meats) is a problem if low gastric acid or poor liver/kidney
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- Effects Of Caffeine And Coffee On Heartburn,. . .
- "Coffee is highly acidic and it can stimulate the hypersecretion of gastric acids."
- "Decaffeinated coffee has been shown to increase acidity to a greater degree than either regular coffee or caffeine alone"
- HOW TO TREAT GOUT, JOINT PAIN.... HAVE HCL THERAPY AND DON’T EAT AFTER 6 PM
- HCL increases gastric acid
- Search Google for (hcl OR "hydrochloric acid") gout > 400,000 web pages as of April 2016
- Many companies on Amazon sell HCL with enzyme to increase stomach acid
1652 Advertisement For Coffee:"It is excellent to prevent and cure the Dropsy, Gout, ...
- 2.4X more likely to have elevated uric acid if low vitamin D and elderly **📄 The 2013 study
Gout pateints with low vitamin D were 3.8 X more likely to be depressed Dec 2018
[http://www.beatinggout.com/2009/03/vitamin-c-and-gout/|Vitamin C** and Gout]
1. See also Vitamin D LifeOverview Kidney and vitamin D and Gout is strongly associated with poor kidney function
Gout, cholera, scarlet fever, TB all increasing in the UK (low vitamin D) – Feb 2019
Gout increased the risk of Hashimoto's Thyroiditis by 3X
Criteria to associate a health problem with low vitamin D contains the following
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43 reasons for Vitamin D deficiency which includes the following chart
Gout has the following chart
1. See also web- Gout and Vitamin D Gout and You
- Review of research. 2015?
- "Gout is quite common and affects about 3.9% or 8.3 million adults in the United States, about 6 million men and 2 million women."
Gout and Magnesium also from Gout and You
Vitamin D for Gout: Get It While It Lasts! Goutkiller ebook
Clinical Trial of Vitamin D to reduce gout renin angiotensin system
Hypothesis: Vitamin D deficiency is due to malfunctioning renin angiotensin system – Jan 2013 in Vitamin D Life
Sleep Apnea Is Tied to Gout New York Times Oct 2015
- Those with Sleep Apnea has 50% increased chance of having Gout
- Vitamin D Life suspects the link is low vitamin D - which is independently associated with both
- Epidemiology of gout has the following chart for the US
- Potential causal associations between vitamin D and uric acid: Bidirectional mediation analysis - 2015
- Search Google for GOUT CBD 1.1 million hits as of Aug 2017
- CBD = the legal form of Marijuana which reduces pain
- 25% Fewer gout flares if recently had Omega-3 fish and had also low purine diet - March 2019
- Effect of Dietary and Supplemental Omega-3 Polyunsaturated Fatty Acids on Risk of Recurrent Gout Flares, doi: 10.1002/art.40896
Low levels of Lead (which also decrease VItamin D levels) increase gout Dr. Greger, 5 minute video Sept 2020
"More than 90% of the total body lead content resides in the bone, where the half-life is decades long,”
Chronic Disease Approaches Needed to Curb Gout’s Growing Burden JAMA March 2018
- "Gout is common in the United States, affecting about 4% of adults."
- The word VITAMIN does not occur once in the PDF
1. Gout in the UK increased 20% in 3 years - Sept 2022Also tuberculosis, malnutrition, whooping cough, measles, scurvy, typhoid, scarlet fever, diphtheria, mumps, rickets, cholera, and vitamin D deficiency
note:Hyperlinks go to Vitamin D Life**
Gout, cholera, scarlet fever, TB all increasing in the UK (low vitamin D) – Feb 2019
1. Gout, RA symptoms sometimes the same, sometimes different
1. Gout epigenetics: Vitamin D, Vitamin D Receptor, Omega-3, etc - Sept 2022
1. 7+ Vitamin D Life pages have GOUT in titleThis list is automatically updated
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