Gestational diabetes – Vitamin D and Calcium provided huge benefits – RCT

Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: randomized, double-blind, placebo-controlled trial.

Public Health Nutr. 2015 Mar 20:1-8. [Epub ahead of print]

Karamali M 1, Asemi Z 2, Ahmadi-Dastjerdi M 1, Esmaillzadeh A 3.

1 Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Islamic Republic of Iran.

2 Department of Nutrition, Research Center for Biochemistry and Nutrition in Metabolic Diseases,Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.

3 Food Security Research Center,Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.

60 women with GDM in Iran – randomized half of them supplementing with50,000 IU vitamin D twice – at day 1 and day 211 gram of Calcium daily for 6 weeks 1. || |Vitamin D | No DCaesarean section rate |23 % | 63 %Maternal hospitalization| 0 %|13 %Infant Macrosomia (Large for gestational age) |0 %| 13 %Infant hyperbilirubinaemia|30 %|57 % ||Notes by Vitamin D Life1. ~2400 IU daily for Iranian women (who are typically very vitamin D deficient)1. Some of the women will probably have had high BMI1. Vitamin D dose needed for high BMI is 2-3 more than for normal BMI ((dose did not vary with weight in this study)1. Unsure if the Calcium is neededSee also Vitamin D Life* gestational diabetes" 180 items as of April 2014* Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014 * same author?* Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT Nov 2014 same study, different publication?See also webIncreasing Prevalence of Gestational Diabetes and Pregnancy-Related Hypertension in Los Angeles County, California, 1991–2003Gestational diabetes (top of chart = 1%)Racial/Ethnic Differences in the Percentage of Gestational Diabetes Mellitus Cases Attributable to Overweight and Obesity, Florida, 2004-2007Gestational Diabetes Risk Factors Mayo ClinicAge greater than 25, Family or personal health history,BMI> 30, Nonwhite raceWebMD adds the following factorsPreviously giving birth to a baby over 9 pounds, given birth to a stillborn baby, previously had gestational diabetes

OBJECTIVE:

The present study was designed to assess the effects of Ca+vitamin D supplementation on pregnancy outcomes in women with gestational diabetes mellitus (GDM).

DESIGN:

A randomized, double-blind, placebo-controlled trial was conducted among sixty women with GDM. Participants were divided into two groups to receive Ca+vitamin D supplements or placebo. Individuals in the Ca+vitamin D group (n 30) received 1000 mg Ca/d and two pearls containing 1250 µg (50 000 IU) of cholecalciferol (vitamin D3) during the intervention (one at study baseline and another at day 21 of the intervention); those in the placebo group (n 30) received two placebos of vitamin D at the mentioned times and placebos of Ca every day for 6 weeks. Pregnancy outcomes were determined.

SETTING:

A urban community setting in Arak, Iran.

SUBJECTS:

Sixty women with GDM and their newborns, living in Arak, Iran were enrolled.

RESULTS:

Women treated with Ca+vitamin D had a significant decrease in caesarean section rate (23·3 % v. 63·3 %, P=0·002) and maternal hospitalization (0 v. 13·3 %, P=0·03) compared with those receiving placebo. In addition, newborns of GDM women randomized to Ca+vitamin D had no case of macrosomia, while the prevalence of macrosomia among those randomized to placebo was 13·3 % (P=0·03). Lower rates of hyperbilirubinaemia (20·0 % v. 56·7 %, P=0·03) and hospitalization (20·0 % v. 56·7 %, P=0·03) were also seen in the supplemented group of newborns than in the placebo group.

CONCLUSIONS:

Ca+vitamin D supplementation for 6 weeks among pregnant women with GDM led to decreased caesarean section rate and maternal hospitalization, and decreased macrosomia, hyperbilirubinaemia and hospitalization in newborns.

PMID: 25790761

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