Genes which regulate active vitamin D worsen with age

Created October 2016

Vitamin D, calcium homeostasis and aging.

Bone Res. 2016 Oct 18;4:16041. eCollection 2016.

Veldurthy V1, Wei R1, Oz L1, Dhawan P1, Jeon YH1, Christakos S1.

1Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School , Newark, NJ 07103, USA.

Blood tests cannot detect changes in active vitamin DInvisible Genes: Vitamin D Receptor, GC, CYP27B1, and CYP24A1 See also Vitamin D Life* Calcitriol, not inactive vitamin D, associated with pain in seniors – Aug 2014* This appears to agree with the study on this pageGenetics category listing contains the following {include}Items in both categories Genetics and Seniors are listed here: {category}Vitamin D Receptor category has the following{include}13 reasons why many seniors need more vitamin D (both dose and level) - July 2023 has the following{include}

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Osteoporosis is characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and consequent increase in fracture risk. Evidence is accumulating for an important role of calcium deficiency as the process of aging is associated with disturbed calcium balance. Vitamin D is the principal factor that maintains calcium homeostasis. Increasing evidence indicates that the reason for disturbed calcium balance with age is inadequate vitamin D levels in the elderly. In this article, an overview of our current understanding of vitamin D, its metabolism, and mechanisms involved in vitamin D-mediated maintenance of calcium homeostasis is presented.

In addition, mechanisms involved in age-related dysregulation of 1,25(OH)2D3 action, recommended daily doses of vitamin D and calcium, and the use of vitamin D analogs for the treatment of osteoporosis (which remains controversial) are reviewed. Elucidation of the molecular pathways of vitamin D action and modifications that occur with aging will be an active area of future research that has the potential to reveal new therapeutic strategies to maintain calcium balance.

PMID: 27790378 DOI: 10.1038/boneres.2016.41

Clipped from PDF

  • “We and others have noted that renal CYP24A1, which limits the amount of 1,25 (OH)2D3 by accelerating the catabolism of 1,25(OH)2D3, increases with age.”

  • “In addition, with age there is a defect in 1 α hydroxylation.”

  • . . “there is also an age-related decrease in renal VDR and TRPV5 expression with age,” . .

  • “Some individuals, however, do not respond to vitamin D supplementation with an increase in 25(OH)D. The factors controlling this lack of response are unknown.”

Tags: CYP27B1 Calcitriol Seniors