Early tooth decay 1.9 X more likely if a poor Vitamin D receptor
The relationship between vitamin D receptor gene polymorphism and deciduous tooth decay in Chinese children.
BMC Oral Health. 2017 Jul 11;17(1):111. doi: 10.1186/s12903-017-0398-x.
Kong YY1,2, Zheng JM3, Zhang WJ2, Jiang QZ4,5, Yang XC6, Yu M7, Zeng SJ8.
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BACKGROUND:
In the present study, we explored the link between vitamin D receptor (VDR) BsmI, TaqI, ApaI and FokI gene polymorphisms with deciduous tooth decay in Chinese children.
METHODS:
Our study included 380 Chinese children aged 4-7 years, whose DNA sample was collected from the buccal mucosa. VDR gene polymorphisms was determined by PCR-RFLP.
RESULTS:
The adjusted logistic regression analysis demonstrated that BsmI containing the Bb genotype was linked with the increased risk of deciduous tooth decay ( OR = 1.856 , 95% CI = [1.184, 2.908], p = 0.007). However, VDR polymorphisms ApaI, TaqI and FokI were not associated with deciduous tooth decay (ApaI: OR = 0.839, 95% CI = [0.614, 1.145], p = 0.268; TaqI: OR = 1.150, 95% CI = [0.495, 2.672], p = 0.744; FokI: OR = 0.856, 95% CI = [0.616, 1.191], p = 0.356).
CONCLUSIONS:
Our results showed that VDR BsmI polymorphism was associated with the risk of deciduous tooth decay in Chinese children aged 4-7 years. However, the specific mechanism remains to further verify through experiment.
PMID: 28697775 DOI: 10.1186/s12903-017-0398-x
Another Chinese study found Tooth decay 1.7 X more likely if poor VDR - 2017
Association between Single Nucleotide Polymorphisms in Vitamin D Receptor Gene Polymorphisms and Permanent Tooth Caries Susceptibility to Permanent Tooth Caries in Chinese Adolescent