Dogs with Cancer have low vitamin D, same as humans

Created September 2017

Influence of Various Factors on Circulating 25(OH) Vitamin D Concentrations in Dogs with Cancer and Healthy Dogs.

J Vet Intern Med. 2017 Sep 23. doi: 10.1111/jvim.14834. [Epub ahead of print]

Weidner N1, Woods JP1, Conlon P2, Meckling KA3, Atkinson JL4, Bayle J5, Makowski AJ6, Horst RL6, Verbrugghe A1.

| | | || --- | --- | --- || | Dogs | Humans || Diagnosed with Cancer in lifetime | 25% | 38% || Other diseases also associated with low D | Yes | Yes || Diseases associated with CYP24A1 gene | Yes | Yes || Decreased Vitamin D in food/supplements associated with Cancer | Yes | Yes || Vitamin D reduces pain of arthritis, etc. | Yes | Yes |--- 1. Vitamin D Life - Overview Veterinary and vitamin D contains{include}* Vets give 3X vitamin D than the US govt recommends for animal OR humans* Vets are paid to keep their "patients" healthy, rather than being getting money when "patients" become sickCancer category (for humans) starts with the following{include}--- 1. Vitamin D Life Vet category with CANCER in titleThis list is automatically updated{LIST()}

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BACKGROUND:

Low blood 25-hydroxyvitamin D (25(OH)D) concentrations have been associated with cancer in dogs. Little research has examined what other factors may affect 25(OH)D concentrations.

OBJECTIVES:

(1) To determine whether the presence of cancer (lymphoma, osteosarcoma, or mast cell tumor [MCT]) in dogs is associated with plasma 25(OH)D concentrations and (2) identify other factors related to plasma 25(OH)D concentrations in dogs.

ANIMALS:

Dogs newly diagnosed with osteosarcoma (n = 21), lymphoma (n = 27), and MCT (n = 21) presented to a tertiary referral oncology center, and healthy, client-owned dogs (n = 23).

METHODS:

An observational study design was used. Dietary vitamin D intake, sex, age, body condition score (BCS), muscle condition score (MCS), and plasma concentrations of 25(OH)D, 24,25-dihydroxyvitamin D (24,25(OH)2 D) (a marker of CYP24A1 activity), as well as ionized calcium (ICa), parathyroid hormone, and parathyroid hormone-related protein concentrations were measured. An analysis of covariance was used to model plasma 25(OH)D concentrations.

RESULTS:

Cancer type (P = 0.004), plasma 24,25(OH)2 D concentrations (P < 0.001), and plasma ICa concentrations (P = 0.047) had significant effects on plasma 25(OH)D concentrations. Effects of age, sex, body weight, BCS, MCS, and plasma PTH concentrations were not identified. A significant interaction between ICa and cancer was found (P = 0.005). Plasma 25(OH)D concentrations increased as ICa concentrations increased in dogs with cancer, whereas plasma 25(OH)D concentrations decreased as ICa concentrations increased in healthy dogs.

CONCLUSIONS AND CLINICAL IMPORTANCE:

Results support a relationship between cancer and altered vitamin D metabolism in dogs, mediated by plasma ICa concentrations. The CYP24A1 activity and plasma ICa should be measured in studies examining plasma 25(OH)D concentrations in dogs.

Tags: Cancer Veterinary