Diseases at high risk if just low Vitamin D, low (D and Mg), low (D and Omega-3) – Perplexity AI
Which diseases are at high risk if 1) Just vitamin D deficient, 2) Vitamin D and Magnesium deficient, 3) Vitamin D and Omega-3 deficient?
Low Vitamin D:
Rickets in children and osteomalacia in adults 1
Osteoporosis and increased fracture risk 1
Muscle weakness, pain, and fatigue 12
Depression and mood changes 12
Increased risk of cardiovascular disease 5
Higher susceptibility to infectious diseases 4
Low Vitamin D and low magnesium:
Ineffective Vitamin D metabolism, as magnesium is required to activate vitamin D 3
Increased risk of cardiovascular diseases and metabolic syndrome 4
Enhanced risk of endothelial dysfunction and blood clotting 7
Compromised immune system function 7
Higher oxidative stress and inflammation 7
Increased risk of cytokine storms during infections 7
Low Vitamin D and low omega-3:
Increased autoimmune disease risk (22% higher without supplementation) 8
Higher risk of inflammatory conditions 9
Potential increased risk of:
It's important to note that Vitamin D deficiency affects approximately 1 billion people worldwide, with 50% of the world population having Vitamin D insufficiency 1. The combination of these deficiencies can create more severe health impacts than individual deficiencies alone, particularly affecting immune function and inflammatory responses 7 8.
See all 3 are interrelated
Vitamin D, Omega-3, and Magnesium are synergistic - many studies
These 3 supplements are a no brainer (Vitamin D, Magnesium, Omega-3) - video July 2024
Longevity and healthspan increased by Vitamin D, Omega-3, Magnesium - many studies
See related in Omega-3
150+ Vitamin D Life Magnesium pages have "VITAMIN D" in the title
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See related Magnesium in Vitamin D Life
Magnesium Depletion Score predicts increased risk of various health problems
Magnesium increases Vitamin D and decreases mortality - 2013 10+ studies
The ONE Supplement All Longevity Experts Are Taking (Magnesium) - video and transcript Dec 2023
143+ Vitamin D Life Omega-3 pages have "VITAMIN D" in the title
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Which diseases are associated with 1) just low magnesium, 2) Just low vitamin D, 3) low magnesium and low vitamin D Perplexity AI Jan 2025
Magnesium Deficiency Alone
Type 2 diabetes and insulin resistance 18
Muscle disorders (cramps, spasms, weakness) 1
Hypertension 15
Seizures and neurological manifestations 1
Personality changes and anxiety 1
Vitamin D Deficiency Alone
Rickets in children 22
Osteomalacia in adults 22
Depression and mood disorders 27
Multiple sclerosis 28
Psoriasis 28
Osteoarthritis 28
Chronic kidney disease 28
Combined Deficiency Conditions
When both magnesium and vitamin D levels are low, the following conditions are particularly affected:
Osteoporosis and bone disorders 7
Metabolic syndrome 5
Immune system dysfunction 5
Cancer risk (particularly colorectal, breast, and prostate) 28
Hypertension 26
Autoimmune diseases 26
It's important to note that magnesium is essential for vitamin D metabolism and activation 6. Without adequate magnesium, vitamin D supplementation may be less effective or even ineffective 7. The relationship between these two nutrients is particularly significant because magnesium deficiency can impair vitamin D function even when vitamin D levels appear adequate 11.
Vitamin D proofs and associations
Proof that Vitamin D Works 99+ proofs - summarized, with links to each study
Vitamin D Life - Vitamin D Cofactors in a nutshell table show the importance of Mg, Omega-3, etc.
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