Diabetes helped by daily 4,000 IU of Vitamin D – meta-analysis

Created October 2017

The Effect of Improved Serum 25-Hydroxyvitamin D Status on Glycemic Control in Diabetic Patients: A Meta-Analysis.

J Clin Endocrinol Metab. 2017 Sep 1;102(9):3097-3110. doi: 10.1210/jc.2017-01024.

Mirhosseini N1, Vatanparast H2, Mazidi M3,4, Kimball SM1,5.

1 Pure North S'Energy Foundation, Calgary, Alberta T2R 0C5, Canada.

2 College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5A2, Canada.

3 Key State Laboratory of Molecular Dev. Biology, Institute of Genetics and Dev. Biology, Chinese Academy of Sciences, Beijing 100101, China.

4 Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Sciences, Beijing 100101, China.

5 St. Mary's University, Calgary, Alberta T2X 1Z4, Canada.

1. # The Meta-analysis of Diabetes and Vitamin D{category} 1. # Intervention AND Diabetes (see also Metabolic Syndrome){category} --- 1. The average vitamin D level increase with 4,000 IU was only 17 nanogramsMore reduction in diabetic parameters would be expected if any of the following1. Higher dose for everyone– getting an increase of say 30 nanograms1. Use still higher dose for those at high risk of being deficient (such as obese, dark skin, etc)1. Use a type of vitamin D appropriate for those with poor guts, poor liver, poor kidney, etc

BACKGROUND:

Type 2 diabetes is a global health concern, with an increased prevalence and high cost of treatment.

OBJECTIVE:

The aim of this systematic review and meta-analysis was to determine the effect of vitamin D supplementation and improved vitamin D status on glycemia and insulin resistance in type 2 diabetic patients.

DATA SOURCE:

We searched PUBMED/Medline, Cumulative Index to Nursing and Allied Health, and Cochrane Library (until January 2017).

STUDY SELECTION:

Prospective clinical trials were selected evaluating the impact of vitamin D supplementation on glycosylated hemoglobin (HbA1c), serum fasting plasma glucose (FPG), and homeostatic model assessment of insulin resistance (HOMA-IR) in diabetic patients.

DATA EXTRACTION AND SYNTHESIS:

We used a random-effects model to synthesize quantitative data, followed by a leave-one-out method for sensitivity analysis. The systematic review registration was CRD42017059555. From a total of 844 entries identified via literature search, 24 controlled trials (1528 individuals diagnosed with type 2 diabetes) were included.

The meta-analysis indicated a significant reduction in

  • HbA1c [mean difference: -0.30%; 95% confidence interval (CI): -0.45 to -0.15, P < 0.001],

  • FPG [mean difference: -4.9 mg/dL (-0.27 mmol/L); 95% CI: -8.1 to -1.6 (-0.45 to -0.09 mmol/L), P = 0.003], and

  • HOMA-IR (mean difference: -0.66; 95% CI: -1.06 to -0.26, P = 0.001)

following vitamin D supplementation and significant increase in serum 25-hydroxyvitamin D levels [overall increase of 17 ± 2.4 ng/mL (42 ± 6 nmol/L)].

CONCLUSIONS:

Vitamin D supplementation, a minimum dose of 100 µg/d (4000 IU/d), may significantly reduce serum FPG, HbA1c, and HOMA-IR index, and helps to control glycemic response and improve insulin sensitivity in type 2 diabetic patients.

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Tags: Diabetes Meta-analysis