Diabetes
items In Diabetes category 34+ Prediabetes studies 64+ Type 1 Diabetes studies
see also Overview Diabetes and vitamin D Overview Metabolic Syndrome and vitamin D
Autoimmune category listing has items along with related searches
34+ Vitamin D Life pages with PREDIABETES or PREDIABETIC in title
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Prediabetics helped by Vitamin D - umbrella of 31 RCTs Aug 2025
Effects of vitamin D supplementation on metabolic parameters, anthropometric measures, and diabetes risk in patients with prediabetes: an umbrella review of meta-analyses of randomized controlled trials
Nutrition & Metabolism (2025) 22:99 https://doi.org/10.1186/s12986-025-00994-1
Roghayeh Molani-Gol, Maryam Rafraf & Sara Safari
Note the huge differences between meta-analyses in both dose and duration
Background
The prevalence of prediabetes and, consequently, type 2 diabetes is increasing around the world. Previous meta-analyses reported controversial findings regarding the association between vitamin D supplementation with glycemic control and diabetes risk. This comprehensive meta-analysis summarized existing research to provide an estimate of the impact of vitamin D supplementation on metabolic parameters and diabetes risk in individuals with prediabetes.
Method
A comprehensive systematic search was conducted across the Web of Science, Scopus, PubMed, and Cochrane databases, and Google Scholar using relevant keywords until 22 July 2025. The AMSTAR2 scale was used to evaluate the methodological quality of the included articles. Moreover, the certainty of the evidence was assessed using the GRADE tool. Stata 17 software was used for data analysis.
Results
Fourteen meta-analyses comprising 31 randomized controlled trials (RCTs) of 3856 prediabetic patients were included in this review. Combining the findings of RCTs revealed that vitamin D supplementation significantly reduced the levels of
fasting blood sugar (WMD= -0.377 mg/dl, 95% CI (-0.589, -0.165), p < 0.001),
insulin (WMD = -0.174 µU/mL, 95% CI (-0.274, 0.074), p < 0.001),
hemoglobin A1c (WMD = -0.479%, 95% CI (-0.714, -0.245), p < 0.001), and
serum triglyceride (TG) (WMD = -0.385 mg/dl, 95% CI (-0.622, -0.147), p = 0.002)
- in comparison with the control group.
The effects of vitamin D on insulin resistance by homeostasis model assessment, 2-hour oral glucose tolerance test plasma glucose, homeostasis model assessment of β-cell function, body mass index, and diabetes risk of participants were not significant.
Conclusion
The findings of this umbrella review suggested that vitamin D supplementation could help to improve some glycemic indices and TG levels. However, due to discrepancies among the results, more well-designed RCTs are warranted to confirm and clarify the impacts of vitamin D supplementation in prediabetic patients.
📄 Download the PDF from Vitamin D Life
Diabetes increases the risk of other health problems
Diabetes leads to many diseases - need to restore the vitamin D levels
Diabetes ==> Cognitive impairment
Diabetes ==> Vertebral fracture in men only
Diabetes ==> Rheumatoid Arthritis
Diabetes ==> Pancreatic Cancer
Depression <==> Diabetes 2 way interaction
Vitamin D Life Diabetes pages with NEUROPATHY in title (14 as of Aug 2022)
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📄 The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach - Jan 2020
Vitamin D Life Diabetes pages with INSULIN in title (xx as of Drpy 2025)
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All Diabetes articles
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All categories associated with Diabetes
Intervention55; Pregnancy42; Infant-Child38; Meta-analysis36; Obesity32; Cardiovascular31; Magnesium25; Skin - Dark24; Intervention - non daily22; Vitamin D Receptor22; Metabolic Syndrome15; Hypertension13; Kidney12; Genetics12; Omega-311; Cognitive10; Depression10; Cancer9; Autoimmune9; Deficiency9; Virus8; Loading dose8; Inflammation8; Vision7; Mortality 7; Rheumatoid Arthritis7; Middle East6; Injection6; Immunity6; Antibiotics, probiotics6; Multiple Sclerosis6; Lupus6; Stroke5; Vitamin K5; Youth5; Vit D Binding Protein5; Bone - Health4; Pain - chronic4; Thyroid and parathyroid4; Books, videos 4; Sports 4; Fortification4 As of Oct 2022 Click to generate detailed associations
Close Associations
Type 1 Diabetes (most are adults)
50+ Vitamin D Life Diabetes pages have T1 or TYPE 1 in the title
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T1 Diabetes in Adults - review April 2022
Type 1 Diabetes: A Systematic Review From 32 Countries and Regions
📄 Download the PDF from Vitamin D Life
T1 Diabetes on web
- GrassrootsHealth New Project Launch - Type 1 Diabetes Prevention! Aug 2018
- Prevent T1D with Vitamin D and Omega-3
Increased T1 Diabetes in those >65: 12% 1990, 17% in 2019.
More and More Are Living With Type 1 Diabetes Into Old Age MD Edge June 2024]