Depression 1.6 X more likely if low Vitamin D, taking Vitamin D reduces depression – umbrella of meta-analyses

Vitamin D protects against depression: Evidence from an umbrella meta-analysis on interventional and observational meta-analyses

Pharmacological Research Volume 187, January 2023, 106605 https://doi.org/10.1016/j.phrs.2022.106605

Vali Musazadeh a b, Majid Keramati a b, Faezeh Ghalichi a c, Zeynab Kavyani a b, Zohre Ghoreishi d, Kamar Allayl Alras e, Naryman Albadawi f, Abdullah Salem e, Mohamed Ismail Albadawi g, Raghad Salem h, Ahmed Abu-Zaid e i 1, Meysam Zarezadeh a c, Rania A. Mekary j

Meta-analyses of interventional and observational studies investigating the efficacy and the relationship between vitamin D and depression provided inconsistent results. The current umbrella meta-analysis was conducted to assess the available evidence and provide a conclusive outcome in this regard. The following international databases were systematically searched till March 2022: PubMed, Scopus, Embase, Web of Science, and Google Scholar. Random-effects model was carried out to calculate the pooled point estimates and their respective 95 % confidence intervals (CI). Ten meta-analyses of randomised controlled trials (RCTs) revealed significant reduction in depression symptoms comparing participants on vitmain D supplements to those on placebo (Pooled standardised mean difference: − 0.40; 95 % CI: − 0.60, − 0.21, p < 0.01: I2 = 89.1 %, p < 0.01).

Four meta-analyses of cohort studies (with one having two subgroups) revealed that participants with lower levels of serum vitamin D were at increased odds of depression than those with higher levels of serum vitamin D (Pooled odds ratio: 1.60 ; 95 % CI: 1.08, 2.36, p < 0.01; I2 = 91.3 %, p < 0.01). The present umbrella meta-analysis confirms the potential benefits of vitamin D supplementation and higher serum vitamin D levels in reducing the development and symptoms of depression.

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Vitamin D Life – Depression contains

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Meta-analyses of Vitamin D and Depression

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