Curcumin may increase Vitamin D in tissues (activates Vitamin D Receptor)

Created May 2019

Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention

J Nutr Biochem. 2010 Dec;21(12):1153-61. doi: 10.1016/j.jnutbio.2009.09.012.

Bartik L1, Whitfield GK, Kaczmarska M, Lowmiller CL, Moffet EW, Furmick JK, Hernandez Z, Haussler CA, Haussler MR, Jurutka PW.

1 Department of Biochemistry and Molecular Biophysics, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA.

* Some essential oils improve health by improving the vitamin D receptor* Curcumin reduces diabetes and many other health problems* * Curcumin category listing has items along with related searches** Vitamin D Receptor table shows what increases VDR activation{include}Warning about Curcumin by Henry Lahore, Founder of Vitamin D Life - Summer 2017The only time I have ever been in a hospital was due to a kidney stone. was this year at age 712 weeks before the hospital visit I had started taking some highly-bioavailable CurcuminWhen I got home later that morning I Googled "Kidney stones" curcumin I got 200,000 hitsCurcumin has a lot of oxalates, which " bind to calcium, and form insoluble calcium oxalate, which is responsible for approximately three-quarters of all kidney stones"I now use standard-strength curcumin daily, with no problemsBy the way, I got rid of my small kidney stone by using a vibrator--- 1. Curcumin ReviewsExamine.com summaries 37 aspects Nov 2019---Google Scholar found 147 studies cited this study as of July 2023* Vitamin D status and its management for achieving optimal health benefits in the elderly – Oct 2018 https://doi.org/10.1080/17446651.2018.1533401* Chapter 87 - Nonsecosteroidal Ligands and Modulators of Vitamin D Receptor – 2018 Book chapter https://doi.org/10.1016/B978-0-12-809963-6.00087-0* A Phase II Study of Curcumin and Vitamin D in Previously Untreated Patients with Early Stage Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) – 2018 https://doi.org/10.1182/blood-2018-99-112295* Molecular Mechanisms of Vitamin D Action – Feb 2013 https://doi.org/10.1007/s00223-012-9619-0* Curcumin, a promising anti-cancer therapeutic: a review of its chemical properties, bioactivity and approaches to cancer cell delivery – 2014 10.1039/C3RA46396F* Regulation of target gene expression by the vitamin D receptor - an update on mechanisms – March 2012 https://doi.org/10.1007/s11154-011-9198-9 * Vitamin D and energy homeostasis—of mice and men – Nov 2013 https://doi.org/10.1038/nrendo.2013.226* Prevention and Treatment of Colorectal Cancer by Natural Agents from Mother Nature – March 2013 https://doi.org/10.1007/s11888-012-0154-1Curcumin fights COVID-19* [Curcumin Inhibits Virus-Induced Cytokine Storm](https://articles.mercola.com/sites/articles/archive/2020/07/06/curcumin-cytokine-storm.aspx?cid_source=dnl&cid;_medium=email&cid;_content=art1HL&cid;=20200706Z1∣=healthrtlucm20200706z1&rid;=910147424) Mercola July 2020* Anti-infective Properties of the Golden Spice Curcumin May 2019 FREE PDF* The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia June 2020 FREE PDF

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Clipped from PDF: 8 grams of Curcumin

  • “Activation of VDR by CM required a much higher concentration (10−6 to 10−5 M) than the endocrine 1,25D ligand (10−8M), suggesting that a relatively low-affinity ligand may not achieve physiologic levels. However, up to 8 g of CM can be safely administered orally to human subjects on a daily basis, potentially leading to plasma concentrations greater than 10−6M [33]”

The nuclear vitamin D receptor (VDR) mediates the actions of 1,25-dihydroxyvitamin D(3) (1,25D) to regulate gene transcription. Recently, the secondary bile acid, lithocholate (LCA), was recognized as a novel VDR ligand. Using reporter gene and mammalian two-hybrid systems, immunoblotting, competitive ligand displacement and quantitative real-time PCR, we identified curcumin (CM), a turmeric-derived bioactive polyphenol, as a likely additional novel ligand for VDR. CM (10(-5) M) activated transcription of a luciferase plasmid containing the distal vitamin D responsive element (VDRE) from the human CYP3A4 gene at levels comparable to 1,25D (10(-8) M) in transfected human colon cancer cells (Caco-2). While CM also activated transcription via a retinoid X receptor (RXR) responsive element, activation of the glucocorticoid receptor (GR) by CM was negligible. Competition binding assays with radiolabeled 1,25D confirmed that CM binds directly to VDR. In mammalian two-hybrid assays employing transfected Caco-2 cells, CM (10(-5) M) increased the ability of VDR to recruit its heterodimeric partner, RXR, and steroid receptor coactivator-1 (SRC-1). Real-time PCR studies revealed that CM-bound VDR can activate VDR target genes CYP3A4, CYP24, p21 and TRPV6 in Caco-2 cells. Numerous studies have shown chemoprotection by CM against intestinal cancers via a variety of mechanisms. Small intestine and colon are important VDR-expressing tissues where 1,25D has known anticancer properties that may, in part, be elicited by activation of CYP-mediated xenobiotic detoxification and/or up-regulation of the tumor suppressor p21. Our results suggest the novel hypothesis that nutritionally-derived CM facilitates chemoprevention via direct binding to, and activation of, VDR.

Tags: Curcumin Vit D Receptor