COVID in hospital fought by Vitamin D (25,000 IU daily for 4 days, then 25K weekly) - RCT

Positive Effects of Vitamin D Supplementation in Patients Hospitalized for COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial

Nutrients 2022, 14(15), 3048; https://doi.org/10.3390/nu14153048

Sophie De Niet et.all

Retrospective studies showed a relationship between vitamin D status and COVID-19 severity and mortality, with an inverse relation between SARS-CoV-2 positivity and circulating calcifediol levels. The objective of this pilot study was to investigate the effect of vitamin D supplementation on the length of hospital stay and clinical improvement in patients with vitamin D deficiency hospitalized with COVID-19. The study was randomized, double blind and placebo controlled. A total of 50 subjects were enrolled and received, in addition to the best available COVID therapy, either vitamin D (25,000 IU per day over 4 consecutive days, followed by 25,000 IU per week up to 6 weeks) or placebo.

The length of hospital stay decreased significantly in the vitamin D group compared to the placebo group (

• 4 days vs. 8 days; p = 0.003).

At Day 7, a significantly lower percentage of patients were

• still hospitalized in the vitamin D group compared to the placebo group (19% vs. 54%; p = 0.0161),

and none of the patients treated with vitamin D were hospitalized after 21 days compared to 14% of the patients treated with placebo.

Vitamin D significantly reduced the duration of supplemental oxygen among the patients who needed it (4 days vs. 7 days in the placebo group; p = 0.012) and significantly improved the clinical recovery of the patients, as assessed by the WHO scale (p = 0.0048). In conclusion, this study demonstrated that the clinical outcome of COVID-19 patients requiring hospitalization was improved by administration of vitamin D.

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Note: All participants initially had <20 ng of vitamin D

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