Changes in CYP3A4 gene affects Vitamin D, health, reactions to some drugs, etc

Interplay of Vitamin D and CYP3A4 Polymorphisms in Endocrine Disorders and Cancer

Endocrinol Metab (Seoul). 2022 Jun 3. doi: 10.3803/EnM.2021.1349

Siva Swapna Kasarla 1, Vannuruswamy Garikapati 2, Yashwant Kumar 1, Sujatha Dodoala 3

Chart of Vitamin D interactions

Chart of CYP3A4 and Vitamin D

Chart of Vitamin D and Calcium

Chart of Vitamin D and Cancer

Chart of Vitamin D and Immune System

Table of CYP3A4 interactions

Vitamin D has received considerable optimistic attention as a potentially important factor in many pathological states over the past few decades. However, the proportion of the active form of vitamin D metabolites responsible for biological activity is highly questionable in disease states due to flexible alterations in the enzymes responsible for their metabolism. For instance, CYP3A4 plays a crucial role in the biotransformation of vitamin D and other drug substances. Food-drug and/or drug-drug interactions, the disease state, genetic polymorphism, age, sex, diet, and environmental factors all influence CYP3A4 activity. Genetic polymorphisms in CYP450-encoding genes have received considerable attention in the past few decades due to their extensive impact on the pharmacokinetic and dynamic properties of drugs and endogenous substances. In this review, we focused on CYP3A4 polymorphisms and their interplay with vitamin D metabolism and summarized the role of vitamin D in

• calcium homeostasis,

• bone diseases,

• diabetes,

• cancer,

• other diseases, and

• drug substances.

We also reviewed clinical observations pertaining to CYP3A4 polymorphisms among the aforementioned disease conditions. In addition, we highlighted the future perspectives of studying the pharmacogenetics of CYP3A4, which may have potential clinical significance for developing novel diagnostic genetic markers that will ascertain disease risk and progression.

PDF Table of Contents

Vitamin D overview

Vitamin D bioconversion

Skin

Liver

Kidney

Role of CYP3A4 in the inactivation of vitamin D

Clinical relevance of CYP3A4 enzymatic studies

VITAMIN D AND ITS PHYSIOLOGICAL ROLE

Calcium homeostasis

Skeletal homeostasis

Immunomodulation

Cancer

Other disease conditions and drugs

CONCLUSIONS

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Vitamin D Life - studies in both categories Genetics and Immune System

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