Cardiovascular system benefits from both Omega-3 and vitamin D
Omega-3 Fatty acids and vitamin d in cardiology.
Cardiol Res Pract. 2012;2012:729670. doi: 10.1155/2012/729670. Epub 2012 Dec 31.
Güttler N, Zheleva K, Parahuleva M, Chasan R, Bilgin M, Neuhof C, Burgazli M, Niemann B, Erdogan A, Böning A.
Department of Cardiology and Angiology, University Hospital Giessen, 35390 Giessen, Germany.
Dietary modification and supplementation play an increasingly important role in the conservative treatment of cardiovascular disease. Current interest has focused on n-3 polyunsaturated fatty acids (PUFA) and vitamin D. Clinical trial results on this subject are contradictory in many aspects. Several studies indicate that n-3 PUFA consumption improves
vascular and cardiac hemodynamics,
triglycerides, and
possibly
- endothelial function,
- autonomic control,
- inflammation,
- thrombosis, and
- arrhythmia.
Experimental studies show effects on
membrane structure and associated functions,
ion channel properties,
genetic regulation, and
production of anti-inflammatory mediators.
Clinical trials evaluating a possible reduction in cardiovascular disease by n-3 PUFA have shown different results.
Supplementation of vitamin D is common regarding prevention and treatment of osteoporosis. But vitamin D also seems to have several effects on the cardiovascular system.
Vitamin D deficiency appears to be related to an
increase in parathyroid hormone levels and
can predispose to essential hypertension and left ventricular hypertrophy,
increased insulin resistance, and
eventually to atherosclerosis and adverse cardiovascular events.
Randomized prospective clinical trials are needed to determine whether vitamin D and omega-3 FA supplementation therapy should be recommended as a routine therapy for primary or secondary prevention of cardiovascular disease.
PMID: 23346457
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