Cancers fought by repurposed drugs - aided by Vitamin D in many ways - Marik

Cancer Care - Approach to the Use of Repurposed Drugs in Patients with Cancer

Independant Medical Alliance (had been FCCC)

Paul E. Marik, MD, FCCM, FCCP; Justus R. Hope, MD

📄 Download the PDF from Vitamin D Life

online PDF and supplementary materials

Limited Therapy (D 7 ways)

Low carbohydrate, Low Glycemic diet. Broccoli sprouts 2x to 3x per week (Sulforaphane (VDR) ), brewed green tea (< 4 cups/day)

Ivermectin (raises D) 0.2-0.4 mg/kg/day (0.3 mg/kg/day)

Doxycycline 50 mg daily taken together with 2 g oral Vitamin C (raises D) (consider cycling after 6 months)

Vitamin D 10 000 U daily and Vitamin K (raises D) 2 100 ug (monitor 25-OH Vit D and PTH levels)

Curcumin (VDR) extract twice daily (high bioavailability). Daily dose of 2 -4 g titrate up to 8 g/day

Melatonin 20 mg at night (titrate up from 5 mg)

Propranolol 10-40 mg twice daily as tolerated

Resveratrol (VDR) 500 mg twice a day (high bioavailable)

Green tea extract (EGCG) twice a day (< 800 mg/day)

Aggressive therapy (D 9 ways)

Low Glycemic “ketogenic diet”

Ivermectin (raises D) 0.4-0.8 mg/kg/day (0.6 mg/kg/day). Increase the dose as tolerated up to 1 mg/kg/day if the response is poor.

Mebendazole 200 mg daily

Doxycycline 50 mg daily taken together with 2g oral Vitamin C (raises D) (consider cycling after 6 months)

Vitamin D 10 000 U daily and Vitamin K (raises D) 2 100 ug (monitor 25-OH Vit d and PTH levels). Titrate to achieve a low normal PTH level (Coimbra Protocol)

Curcumin (VDR) extract twice daily (high bioavailability)

Metformin (VDR) 500 - 1000 mg twice daily

Green tea extract (EGCG) twice a day (< 800 mg/day)

Propranolol 10-40 mg twice daily as tolerated

Melatonin 20 mg at night (titrate up from 5 mg)

Resveratrol (VDR) 500 mg twice a day (high bioavailable)

Modified Citrus Pectin (Pectasol 14.4 g/day; 6 tablets three times a day)

Sulforaphane (VDR) (free stabilized Sulforaphane (VDR) extracted from broccoli seeds); dosage varies

Omega 3 (raises D) fatty acids 2-4 g/day

Atorvastatin 40-80 mg daily or simvastatin 40 mg daily (do not use long term or cause a precipitous reduction of LDL due to increased risk of dementia)

Propranolol 20-40 mg twice daily

Quercetin (VDR) 500-1000 mg twice daily

Colorectal Cancer (D 6 ways)

Ivermectin (raises D)

Curcumin (VDR)

Sulforaphane (VDR)

Metformin (VDR)

Atorvastatin/simvastatin

Modified Citrus Pectin

Propranolol

Resveratrol (VDR)

EGCG

Vitamin D

Mebendazole

Perioperative Cimetidine (400 mg BID for 1 year)

Breast Cancer (D 6 ways)

Mebendazole

Ivermectin (raises D)

Curcumin (VDR)

Propranolol 10-40 mg twice daily as tolerated

Doxycycline and Vitamin C (raises D)

Sulforaphane (VDR)

Modified citrus pectin

Vitamin D

Atorvastatin/simvastatin

Resveratrol (VDR)

EGCG

Prostate Cancer (D 8 ways)

Doxycycline (plus Vitamin C (raises D)

EGCG

Ivermectin (raises D)

Sulforaphane (VDR)

Curcumin (VDR)

Metformin (VDR)

Modified Citrus Pectin (Pectasol 14.4 g/day;6 tablets three times a day)

Vitamin D (aim for Vit D level of 100-150 ng/ml)

Mebendazole

Propranolol 10-40 mg twice daily as tolerated

Resveratrol (VDR)

Zinc (raises D) 15mg (dose < 20mg) for nonmetastatic disease. See caution below*

Quercetin (VDR) (synergizes with EGCG) - in poor responders, consider.

Atorvastatin 40-80mg day

Aspirin 325mg daily

Ketone supplements

Lung Cancer (small cell) (D 4 ways)

Curcumin (VDR)

EGCG

Metformin (VDR)

Mebendazole

Sulforaphane (VDR)

Atorvastatin/Simvastatin

Propanolol

Doxycycline and Vitamin C (raises D)

Ivermectin (raises D)

Vitamin D

Lung Cancer (NSCLC) (D 6 ways)

Mebendazole

Ivermectin (raises D)

Curcumin (VDR)

EGCG

Metformin (VDR)

Sulforaphane (VDR)

Atorvastatin/Simvastatin

Modified citrus pectin

Vitamin D

Doxycycline and Vitamin C (raises D)

Melanoma (D 5 ways)

Mebendazole

Ivermectin (raises D)

Doxycycline plus Vitamin C (raises D)

EGCG

Propranolol

Metformin (VDR)

Sulforaphane (VDR)

Modified citrus pectin

Vitamin D

Ovarian Cancer (D 7 ways)

Mebendazole

Curcumin (VDR)

Sulforaphane (VDR)

Metformin (VDR)

Ivermectin (raises D)

Atorvastatin/Simvastatin

Propranolol

Resveratrol (VDR)

Doxycycline plus Vitamin C (raises D)

Modified citrus pectin

Vitamin D

Endometrial Cancer (uterine cancer) (D 6 ways)

Metformin (VDR)

Curcumin (VDR)

Ivermectin (raises D)

Sulforaphane (VDR)

Mebendazole

EGCG

Resveratrol (VDR)

Atorvastatin

Propranolol

Modified citrus pectin

Vitamin D

Liver Cancer (D 6 ways)

Mebendazole

Ivermectin (raises D)

Curcumin (VDR)

Doxycycline plus Vitamin C (raises D)

Sulforaphane (VDR)

EGCG

Metformin (VDR)

Modified citrus pectin

Propranolol

Melatonin

Vitamin D

Head and Neck Squamous cancer (D 5 ways)

Doxycycline plus Vitamin C (raises D)

EGCG

Metformin (VDR)

Mebendazole

Ivermectin (raises D)

Curcumin (VDR)

Modified citrus pectin

Vitamin D

Esophageal Squamous Cell Carcinoma (D 6 ways)

Curcumin (VDR)

EGCG

Vitamin D

Azithromycin (1,500mg once weekly for 8 weeks)

Quercetin (VDR)

Modified citrus pectin

Ivermectin (raises D)

Mebendazole

Metformin (VDR)

Resveratrol (VDR)

Atorvastatin

Pancreatic cancer (D 6 ways)

Curcumin (VDR)

High dose Vitamin D 3 (Coimbra protocol)

Doxycycline plus Vitamin C (raises D) 2g (PO)

Ivermectin (raises D) (start dose at 1 mg/kg and increase as tolerated)

Metformin (VDR)

Atorvastatin/Simvastatin

Propranolol

Modified citrus pectin

Mebendazole

Vitamin D

High dose IV Vitamin C (raises D) (50- 75g) together with standard chemotherapy (gemcitabine and capecitabine)

Hydroxychloroquine 200-400 mg day; max dose of 5 mg/kg/day to reduce retinopathy risk. Regular eye exams are recommended to detect early signs of retinal toxicity.

Gastric Cancer (D 5 ways)

Atorvastatin

Ivermectin (raises D)

Curcumin (VDR)

Metformin (VDR)

Modified citrus pectin

Resveratrol (VDR)

Vitamin D

Mebendazole

Glioblastoma (D 8 ways)

Curcumin (VDR)

Doxycycline plus Vitamin C (raises D)

Metformin (VDR)

Resveratrol (VDR)

Melatonin

Mebendazole

Sulforaphane (VDR)

Propranolol

Ivermectin (raises D) (See paragraph below for more)

Vitamin D

Atorvastatin/Simvastatin

Zinc (raises D) (30mg day)

EGCG

Repurposed drugs for patients with established stage 4 metastatic disease. (D 5 ways)

Doxycycline (up to 200 mg/day) plus Vitamin C (raises D)

Ivermectin (raises D)

Mebendazole

Curcumin (VDR)

Metformin (VDR)

Resveratrol (VDR)

EGCG

Atorvastatin/Simvastatin

Preventing cancer progression from carcinoma in situ (stage 0 cancer) (D 6 ways)

Doxycycline plus Vitamin C (raises D)

EGCG

Mebendazole

Resveratrol (VDR)

Ivermectin (raises D)

Metformin (VDR)

Sulforaphane (VDR)

Curcumin (VDR)

Propranolol

Modified citrus pectin

Repurposed drugs to treat Lymphoma (adjunctive treatment) (D 6 ways)

Atorvastatin 40-80 mg daily

Metformin (VDR) 500-1000 mg twice a day

Propranolol 10-40 mg twice a day, increase the dose as tolerated

Mebendazole 100 mg twice daily

Vitamin D 10 000 U daily and Vitamin K (raises D) 2 100 ug (monitor 25-OH Vit d and PTH levels). Titrate to achieve a low normal PTH level (Coimbra Protocol)

Curcumin (VDR) (high bioavailable) 2-4 g/day

Green tea (EGCG) extract twice daily (< 800 mg/day)

Quercetin (VDR) 500 -1000 mg twice daily

Ivermectin (raises D) 0.4 mg/kg - 1 mg/kg daily

Repurposed drugs to treat Multiple Myeloma (adjunctive treatment) (D 4 ways)

Atorvastatin 40-80 mg daily

Metformin (VDR) 500-100 mg twice daily

Clarithromycin 500 mg twice daily in 28-day cycles (cycled with adjunctive therapy)

Celecoxib (Celebrex) 100 mg twice/day. Avoid in patients with established ischemic heart disease. Check for drug interactions

Mebendazole 10 0mg twice daily

Propranolol 10-40 mg twice a day, increase the dose as tolerated

Curcumin (VDR) (high bioavailable) 2-4 g/day

Green tea (EGCG) extract twice daily (< 800 mg/day)

Resveratrol (VDR) (high bioavailable) 500mg twice day

Ivermectin (raises D) 0.4 mg/kg - 1 mg/kg daily

Acute Myeloid Leukemia (AML) - Pediatric (no radiation and standard chemo) (D 7 ways)

Resveratrol (VDR)

Ivermectin (raises D)

Curcumin (VDR)

Doxycycline/Vitamin C (raises D) (oral)

Metformin (VDR)

EGCG

Omega 3 (raises D)

Sulforaphane (VDR)

Sarcomas (D 3 ways)

Late diagnosis

High drade and aggressiveness

Large tumor size

Metastasis at diagnosis

Tumor location

Incomplete surgical removal

Tumor heterogeneity

Resistance to conventional therapy

Propranolol (particularly for angiosarcomas)

EGCG

Curcumin (VDR)

Vitamin D

Mebendazole

High dose IV Vitamin C (raises D)

Vitamin D Life: Vitamin D both prevents and treats many Cancers

• Overview Cancer and vitamin D

• Cancer and Vitamin D - many studies

• After Cancer Diagnosis

• Bladder Cancer

• Overview Breast Cancer and Vitamin D

• Overview Cancer-Colon and vitamin D

• Leukemia items

• Liver Cancer items

• Overview Lung cancer and vitamin D

• Lymphoma Cancer

• Other Cancer

• Ovarian Cancer

• Pancreatic Cancer items

• Overview Prostate Cancer and Vitamin D

• Overview Suntan, melanoma and vitamin D

• 15 Cancers prevented and or treated by Vitamin D - Sunil July 2025

• 13 Cancers are helped by Vitamin D – Biobank July 2023

• Vitamin D prevents and treats cancer in many ways – May 2021

• Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019

• 8 ways that Cancer might be prevented by Vitamin D - June 2019

• Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019

• Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018

• Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018

• Melanoma 25 X more likely if low vitamin D – Feb 2018

• AI Ranks Ivermectin the best Drug to Fight Metastatic Cancer - Jan 2025

• Vitamins fight cancer: 9 of the 10 most cited studies were for Vitamin D - Dec 2024

Vitamin D Life - Many ways to increase Vitamin D in blood and cells