Cancer and Vitamin D - many studies

Created October 2022

87 Meta-analyses in Vitamin D Life with CANCER etc in the title

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33 Intervention trials in Vitamin D Life with CANCER etc in title

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18 Omega-3 Vitamin D Life studies with CANCER etc in title (Oct 2022)

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Vitamin D Life – Cancer category contains

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Vitamin D Life – Cancer increases if poor Vitamin D Receptor

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Vitamin D Life – Cancer - After diagnosis category contains

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Vitamin D in Cancer Prevention: Gaps in Current Knowledge and Room for Hope - Oct 2022

Nutrients 2022, 14(21), 4512; https://doi.org/10.3390/nu14214512

by Matthias Henn et. al

(This article belongs to the Special Issue The Role of Vitamin D in Cancer Prevention) - which includes

  • Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project

  • A Phase II Multicenter Trial on High-Dose Vitamin D Supplementation for the Correction of Vitamin D Insufficiency in Patients with Breast Cancer Receiving Adjuvant Chemotherapy

  • Prevention of Advanced Cancer by Vitamin D3 Supplementation: Interaction by Body Mass Index Revisited

  • The Controversial Role of Vitamin D in Thyroid Cancer Prevention

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Table of Contents

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Intensive epigenome and transcriptome analyses have unveiled numerous biological mechanisms, including the regulation of cell differentiation, proliferation, and induced apoptosis in neoplastic cells, as well as the modulation of the antineoplastic action of the immune system, which plausibly explains the observed population-based relationship between low vitamin D status and increased cancer risk. However, large randomized clinical trials involving cholecalciferol supplementation have so far failed to show the potential of such interventions in cancer prevention. In this article, we attempt to reconcile the supposed contradiction of these findings by undertaking a thorough review of the literature, including an assessment of the limitations in the design, conduct, and analysis of the studies conducted thus far. We examine the long-standing dilemma of whether the beneficial effects of vitamin D levels increase significantly above a critical threshold or if the conjecture is valid that an increase in available cholecalciferol translates directly into an increase in calcitriol activity. In addition, we try to shed light on the high interindividual epigenetic and transcriptomic variability in response to cholecalciferol supplementation. Moreover, we critically review the standards of interpretation of the available study results and propose criteria that could allow us to reach sound conclusions in this field. Finally, we advocate for options tailored to individual vitamin D needs, combined with a comprehensive intervention that favors prevention through a healthy environment and responsible health behaviors.

📄 Download the PDF from Vitamin D Life

See also Vitamin D Life

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569,000 hits for search of: Cancer "vitamin d" (supplementation OR RCT OR trial)

Google Scholar Oct 2022)

  • A randomized placebo-controlled trial of vitamin D supplementation for reduction of mortality and cancer: Statistical analysis plan for the D-Health Trial - June 2019 https://doi.org/10.1016/j.conctc.2019.100333 FREE PDF

  • Vitamin D supplementation for prevention of cancer: The D2d cancer outcomes (D2dCA) study= June 2019 https://doi.org/10.1016/j.cct.2019.04.015 FREE PDF 4,000 IU -

  • Effect of Vitamin D3 Supplements on Development of Advanced CancerA Secondary Analysis of the VITAL Randomized Clinical Trial - NOV 2020 https://doi.org/doi:10.1001/jamanetworkopen.2020.25850 FREE PDF

1,008+ Vitamin D Life pages have CANCER etc. in the title

CANCER OR LYMPHOMA OR LEUKEMIA OR MYLENOMA OR Osteosarcoma OR Adenocarcinoma

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Tags: Cancer