Both Vitamin D and Vitamin C fight cancers and aid anticancer drugs

Created June 2018

Insight into the roles of vitamins C and D against cancer: Myth or truth?

Cancer Lett. 2018 May 29;431:161-170. doi: 10.1016/j.canlet.2018.05.039. [Epub ahead of print]

Zhao CN1, Li Y1, Meng X1, Li S2, Liu Q1, Tang GY1, Gan RY3, Li HB4.

* Hypothesis – anticancer benefits from synergy of omega-3 and vitamin D – May 2011* The Anti-cancer Actions of Vitamin D – Jan 2013* Vitamin D and Cancer – Special issue Jan 2013* Less radiation therapy needed if have more vitamin D (lung cancer in lab) – March 2017* Chemotherapy and vitamin D - many studies warning* Breast Cancer chemotherapy 2.7 X more likely to be successful if not vitamin D deficient – Dec 2017* Cancer Chemotherapy and vitamin D – Review March 2013* Hypothesis – Chemotherapy can be aided by Vitamin D – March 2016* Chemotherapy (cisplatin) and vitamin D synergistically stop stomach cancer – Feb 2014* Children with cancer were deficient in Vitamin D, Vitamin C, and Zinc – July 2019Dr. Grant* Evidence that Vitamin D prevents Cancer – Grant Feb 2018* Embrace the Sun – benefits of the sun (Nitric Oxide etc.) – book June 2018* The word Cancer occurs more than 1,000 times in the book--- 1. Cancer category in Vitamin D Life starts with the following{include}

The consumption of vitamins C and D for prevention and treatment of cancer is still an uncertain recommendation due to their controversial roles in cancer. The epidemiological studies document that vitamins C and D possess potential antineoplastic property. In addition, accumulating experimental studies strongly support their anticancer efficacy both in vitro and in vivo, although the mechanisms of action are not completely clear. Vitamin C at pharmacological concentration has cancer-selective cytotoxicity in several cancer cell lines. Moreover, the cognition of vitamin D has become "hormone D", which modulates a variety of molecular targets and signaling pathways, contributing to the inhibition of cancer. Furthermore, limited small-scale clinical trials favor their roles as the adjuncts of standard cancer therapies. On the other hand, opposite opinions also exist, and high-quality evidence are still lacking to ascertain the roles of vitamins C and D in cancer. In general, in light of the potential and promising anticancer values of vitamins C and D, it is essential to gain insight into their roles in cancer based on current epidemiological, experimental and clinical studies.

PMID: 29857128 DOI: 10.1016/j.canlet.2018.05.039

PDF is available free at Sci-Hub 10.1016/j.canlet.2018.05.039

Tags: Cancer Vitamin C