Benefits of Omega-3 plus Vitamin D were additive – RCT
Effect of omega-3 and vitamin D co-supplementation on psychological distress in reproductive-aged women with pre-diabetes and hypovitaminosis D: A randomized controlled trial
Brain and Behaviour https://doi.org/10.1002/brb3.2342
Masoumeh Rajabi-Naeeni,Mahrokh Dolatian,Mostafa Qorbani,Amir Abbas Vaezi,
Summary article by GrassrootsHealth
2 + 2 = 4
Expect to find that vitamin D is al least synergistic with Omega-3 for many health problems
Omega-3 and Vitamin D each treat many mental health problems - April 2018
Anticipate finding other synergistic combinations, such as:
Vitamin D + (Resveratrol or Curcumin or Querctin or Zinc)
Purpose
Psychological distresses and pre-diabetes are among the risk factors of developing type-II diabetes. The present study was conducted to determine the effectiveness of omega-3 and vitamin D co-supplementation on psychological distresses in women of reproductive age with pre-diabetes and hypovitaminosis D.
Methods
The present factorial clinical trial was conducted on 168 women of reproductive age with pre-diabetes and hypovitaminosis D. These participants were selected by stratified random sampling and were assigned to four groups for 8 weeks: group 1 (placebo group), group 2 (omega-3 group), group 3 (vitamin D group), and group 4 (co-supplement group). The medication and placebo doses being two 1000-mg tablets each day for omega-3 and 50,000-IU pearls every 2 weeks for vitamin D. Fasting blood glucose and vitamin D were measured at the beginning of the study. The Depression Anxiety Stress Scale-21 and the Pittsburgh Sleep Quality Index were completed by the participants at the start and end of the intervention.
Results
A significant difference was observed in terms of reduction in anxiety and improvement in sleep quality in the co-supplementation compared to the other three groups (p < .05). There was also a significant difference between the group receiving both supplements and the group receiving only placebos in terms of reduction in depression and stress (p < .05).
Conclusion
Vitamin D and omega-3 co-supplementation improved depression, anxiety, and sleep quality in women of reproductive age with pre-diabetes and hypovitaminosis D. Therefore, these two supplements can be recommended for improving the mental health of this group of women.
Clinical trial registry
Iranian Registry of Clinical Trials Code: IRCT20100130003226N17. Registered on February 9, 2019.
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