Autism in children reduced by Vitamin D (used 300 IU per kg per day) – RCT

Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder

Journal of Child Psychology and Psychiatry, First published: Oct 2016 DOI: 10.1111/jcpp.12652

Khaled Saad, Ahmed A. Abdel-Rahman, Yasser M. Elserogy, Abdulrahman A. Al-Atram, Amira A. El-Houfey, Hisham A. K. Othman, Geir Bjørklund, Feiyong Jia, Mauricio A. Urbina, Mohamed Gamil M. Abo-Elela, Faisal-Alkhateeb Ahmad, Khaled A. Abd El-Baseer, Ahmed E. Ahmed, Ahmad M. Abdel-Salam

Retracted: This study was retracted by publisher May 2019 "A number of significant discrepancies emerged between the re‐analysis and the findings reported in the paper both in terms of means and standard deviations of key outcome variables across the trial. "| | | || --- | --- | --- || | At start | 4 months later || CARS
Autism Rating Scale | 37 | 30 || Irritability | 22 | 10 || Social Responsiveness
    lower is better | 75 | 71 || Hyperactivity | 26 | 16 || Lethargy | 18 | 11 || Inappropriate Speech | 7 | 4 || Vitamin D
all had > 20 ng at start | 26 ng | 46 ng |Vitamin D Life speculates even more improvements if* Only considered those children gettting > 40 ng of Vitamin D* Had started with a loading dose (4 months is a fairly short time)* Give more Vitamin D to children for poor risk of Autism by 2X* Note: Vitamin D Receptor test costs $23.* Wild guess: 50% more vitamin D would be needed for those with poor VDR* Had added some cofactors - Magnesium and Omega-3 * Both are often mentioned with Autism and both deal with poor Vitamin D ReceptorsSee also Vitamin D Life* Autism is associated with low vitamin D – meta-analysis Oct 2015* Autism much more likely if poor Vitamin D Receptor – many studies* Autism and Vitamin D massive review – latitude, season, migration, VitD levels and intervention – April 2016* Autism and vitamin D evidence - Cannell Feb 2016* Autism Causes, Prevention and Treatment: Vitamin D Deficiency etc. – Book April 2015* Overview Autism and vitamin D* Autism treated by Vitamin D: Dr. Cannell - video June 2013* Recommend 100 IU of vitamin D per kg of infant - Poland July 2011 has the following chart    This study used a dose which was 3X larger: 300 IU/kg == 3,000 IU/25 lbsFiles in both categories of Intervention AND Autism{category}

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Video about this study which proved benefit

and previous studies of Omega-3 and Vitamin C which found no benefit

Dietary Supplements for Autism NutritionFacts.org Sept 2018

Background:

Autism spectrum disorder (ASD) is a frequent developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and nonverbal communication, and stereotyped patterns of interests and activities. It has been previously reported that there is vitamin D deficiency in autistic children; however, there is a lack of randomized controlled trials of vitamin D supplementation in ASD children.

Methods

This study is a double-blinded, randomized clinical trial (RCT) that was conducted on 109 children with ASD (85 boys and 24 girls; aged 3–10 years ). The aim of this study was to assess the effects of vitamin D supplementation on the core symptoms of autism in children. ASD patients were randomized to receive vitamin D3 or placebo for 4 months. The serum levels of 25-hydroxycholecalciferol (25 (OH)D) were measured at the beginning and at the end of the study. The autism severity and social maturity of the children were assessed by the Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and the Autism Treatment Evaluation Checklist (ATEC). Trial registration number: UMIN-CTR Study Design: trial number: UMIN000020281.

Results

Supplementation of vitamin D was well tolerated by the ASD children. The daily doses used in the therapy group was 300 IU vitamin D3/kg/day, not to exceed 5,000 IU/day. The autism symptoms of the children improved significantly, following 4-month vitamin D3 supplementation, but not in the placebo group. This study demonstrates the efficacy and tolerability of high doses of vitamin D3 in children with ASD.

Conclusions

This study is the first double-blinded RCT proving the efficacy of vitamin D3 in ASD patients. Depending on the parameters measured in the study, oral vitamin D supplementation may safely improve signs and symptoms of ASD and could be recommended for children with ASD. At this stage, this study is a single RCT with a small number of patients, and a great deal of additional wide-scale studies are needed to critically validate the efficacy of vitamin D in ASD.

Social Responsiveness (SRS) of 22,000 Japanese children

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