Atopic Dermatitus more likely if e-cigarette, passive smoke while pregnant or Caesarean

E-Cigarette use increased risk of Atopic Dermatitis Risk by 24% - May 2024

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Passive smoking while pregnant increased Atopic Dermatitis Risk in Children by 52% - March 2024

Maternal tobacco exposure during pregnancy and atopic dermatitis in offspring: A systematic review and meta-analysis

Ling Chao, Wenjuan Liang, Xiangmei Zhao, Zhenzhen Liang, Weidong Wu, Jie Song, Wenjie Ren

First published: 14 March 2024 https://doi.org/10.1111/jdv.19958

The main purpose of this review was to examine the evidence of the relationship between active smoking or passive smoking during pregnancy and atopic dermatitis in offspring. The protocol was written following the PRISMA Checklist and was registered in the PROSPERO database (registration number CRD42022381136). We implemented a comprehensive search in PubMed, Embase and Web of Science databases to identify all potentially related articles from inception through 1 December 2022. We assessed cohort studies and case–control studies using the Newcastle–Ottawa Scale (NOS), and the Joanna Briggs Institute (JBI) critical appraisal tool to assess the quality of cross-sectional studies. Heterogeneity was investigated by using Cochrane Q tests and I2 statistics. In addition, according to the research design, population source and population size, the reasons for the heterogeneity were analysed. A total of 15 observational studies were included in this analysis.

Our meta-analysis suggests that atopic dermatitis in offspring is not associated with active smoking during pregnancy (pooled OR, 0.96 [95% CI 0.86–1.07]); however, it is related to passive smoking (OR, 1.52 [95% CI 1.36–1.70]). Passive smoking during pregnancy is associated with an increased risk of eczema development in offspring. More research is needed to explore the risk of active smoking and eczema development in offspring, especially the association between measurements of pregnancy cotinine levels in maternal body fluids and AD in offspring.


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Vitamin D Life – Atopic Dermatitis and Eczema - many studies

Has the following Table of Contents as of May 2024

Food and mite allergies strongly associated with low vitamin D - April 2024

How to prevent Atopic Dermatitis (Eczema) in 2024: theory and evidence – April 2024

Efficacy of vitamin D supplementation on the severity of atopic dermatitis in children: A systematic review and meta-analysis - Sept 2023

Worse Atopic Dermatitis is associated with lower vitamin D – Sept 2023

Atopic Dermatitis: 8 ng lower vitamin D - meta-analysis Aug 2022

Atopic Dermatitis 5X more likely if low Vitamin D - Aug 2019

Atopic Dermatitis: treated by Vitamin D – Review of Micronutrients – March 2019

Atopic dermatitis treatment needs more than 5,000 IU of Vitamin D – RCT Sept 2018

Atopic Dermatitis reduced by 5,000 IU of Vitamin D for 12 weeks – RCT Dec 2018

Increased risk of AD, etc if poor vitamin D Receptor or CYP24A1 gene - June 2023

Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis - July 2011

See also Vitamin D Life

6 Interventions AND Skin in Vitamin D Life

11 Inflamation studies AND Skin in Vitamin D Life

17+ Vitamin D Life pages with ATOPIC or ECZEMA in title

What is the difference between atopic dermatitis and eczema?

Types of eczema

Seborrheic Dermatitis 4.2X more likely if <30 ng of Vitamin D - Feb 2021

See also web

Typical Eczema sites on body, scratching - images from web

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Vitamin D Life – Increased risk of atopic dermatitis with low vitamin D during pregnancy perhaps due to poor methylation – Oct 2018


Vitamin D Life – Off topic: Caesarean section increases risk of Eczema (Atopic dermatitis) by 1.8 X – Sept 2015