An activated Vitamin D Receptor fights Autoimmune Diseases, Infections, Cancers, etc.

Methylation of the Vitamin D Receptor Gene in Human Disorders

Int. J. Mol. Sci. 2024, 25(1), 107; https://doi.org/10.3390/ijms25010107

by Beatrice Gasperini 1,†,Angela Falvino 1,†,Eleonora Piccirilli 2,Umberto Tarantino 2ORCID,Annalisa Botta 1,*ORCID and Virginia Veronica Visconti 1ORCID

1 Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy

2 Department of Clinical Sciences and Translational Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy

The Vitamin D Receptor (VDR) mediates the actions of 1,25-Dihydroxvitamin D3 (1,25(OH)2D3), which has important roles in bone homeostasis, growth/differentiation of cells, immune functions, and reduction of inflammation. Emerging evidences suggest that epigenetic modifications of the VDR gene, particularly DNA methylation, may contribute to the onset and progression of many human disorders. This review aims to summarize the available information on the role of VDR methylation signatures in different pathological contexts, including autoimmune diseases, infectious diseases, cancer, and others. The reversible nature of DNA methylation could enable the development of therapeutic strategies, offering new avenues for the management of these worldwide diseases.

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• “VDR methylation in infectious diseases”,

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• “VDR methylation AND Osteoporosis”,

• “VDR methylation AND Male infertility”,

• “VDR methylation AND Recurrent Kidney stone formation”,

• “VDR methylation AND Type 2 Diabetes Mellitus”.

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