Ampli-D (calcidiol/calcifediol) can be purchased without a prescription in some countries
Perplexity AI - Dec 2025
Ampli-D (calcidiol/calcifediol) can be purchased without a prescription in some countries and is starting to appear in a few U.S.-marketed supplements, but it is not yet widely available OTC everywhere.[1][2][3][4][5]
Regulatory status
- Ampli-D (calcifediol as a vitamin D ingredient) has regulatory approval as a supplement ingredient in Australia, Singapore, and New Zealand, and was recently approved as a novel food ingredient in the European Union.[2][5][1]
- In these markets it is used in dietary supplements rather than as a prescription-only drug, so it is effectively available OTC where sold.[6][1][2]
Where it is sold OTC
- Australia has practitioner and retail products that include Ampli-D (e.g., tablets such as Opti Active D and other “Rapid D”/similar formulations), typically sold via pharmacies or practitioner channels without a prescription.[7][2][6]
A U.S.-accessible online product “F‑D 3X Calcifediol (ampli‑D) Vitamin D Supplement” lists calcifediol (Ampli‑D) as the vitamin D source and ships from Australia, positioned clearly as an OTC dietary supplement.[3]
- ($60 for 60 capsules of 10 ug each)
A U.S. vitamin D + K product from Lifeforce explicitly states it uses Ampli‑D (calcifediol) as the vitamin D source and is sold as a normal online supplement (no Rx indicated).[4]
- ($55 for 60 capsules of 20 ug of Calcidol + Vitamin K perhaps K2)
Practical takeaway for you
- Yes, calcidiol as Ampli‑D can be obtained OTC via:
- Australian practitioner/retail supplement brands that use Ampli‑D.[2][7][6]
- U.S.-marketed supplements that specify “calcifediol as Ampli‑D” (e.g., Lifeforce D+K) and some third‑party sellers offering F‑D 3X Calcifediol (Ampli‑D) capsules online.[3][4]
- Availability is still patchy, so product labels must be checked carefully to confirm that the vitamin D form is calcifediol (Ampli‑D), not standard cholecalciferol.
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Used to be OTC in Spain, but too many ignored the monthly recommendation and took it daily
getting hypercalcemia