Abu Dhabi 2012 - Hollis
Presented at International Symposium on Vitamin D Deficiency - Abu Dhabi March 2012
Prof. Bruce Hollis
Qualifications: Ph.D.
Position: Director of Pediatric Sciences at the Medical University of South Carolina, USA
Vitamin D Supplementation during Pregnancy and Its Effect on Pregnancy Outcomes
The function and requirement of vitamin D during pregnancy for both mother and fetus has remained a mystery.
This fact was highlighted by The Cochrane Review in 1999 that reported a lack of randomized controlled trials (RCTs) with respect to vitamin D requirements during pregnancy.
Unfortunately, during the past decade only a single RCT has been performed with respect to vitamin D requirements during pregnancy.
In this review we will discuss vitamin D metabolism during pregnancy as well as the consequences of vitamin D deficiency on skeletal, non-skeletal and birth outcomes using birth observational data and data from our recent RCT.
New RCT data strongly support previous observational studies in that improving nutritional vitamin D status will improve birth outcomes.
The new RCT data indicates that 4,000 IU/d vitamin D3 during pregnancy will "normalize" vitamin D Metabolism and improve birth outcomes including primary cesarean section and co-morbidities of pregnancy with no Risk of side effects.
PDF [tiki-download_file.php?fileId=2117]
Sample slides
See also Vitamin D Life
International Symposium on Vitamin D Deficiency - Abu Dhabi March 2012
Dark skin births are much riskier due to lack of vitamin D big concern for the Middle East
CDC vitamin D statistics for women: including blacks and high BMI – March 2012 which has the following chart
- Overview Vitamin D: Before, During, and After Pregnancy many items by Dr. Hollis
- Summary of Overview as of March 2012
| Dose IU | Cumulative Benefit | Blood level and notes | Co-factors (see list) | Calcium | $*/year |
| 400 | * less infant rickets |
+ 3X less adolescent Schizophrenia
+ fewer child seizures | <30 ng/ml | Not needed | No effect | $3 || 2000 | * More likely to get pregnant naturally or via IVF
+ fewer dental problems with pregnancy
+ 8X less diabetes
+ 4X fewer C-sections (>37 ng)
+ 4X less preeclampsia (40 ng vs 10 ng)
+ 5X less child asthma
+ 2X less language problems age 10 | 42 ng/ml | Desirable | < 750 mg | $12 || 4000 | * 2X fewer pregnancy complications
+ 2X fewer per-term births | 49 ng/ml
Test Vitamin D | Must have | < 750 mg | $175 || 6000 | * probable larger benefits for items listed above
+ Enough D for breastfed infant
+ Perhaps prevent 2nd autistic child | Test Vitamin D
clinical trials underway | Must have | < 750 mg | $200 |