400 IU of vitamin D helped a few adults (Orthodox Jewish mothers - heavy clothing) – 2001

Cannot recall a single other study that found 400 IU for an adult could be even detected

Vitamin D Deficiency and Insufficiency in Orthodox and Non-Orthodox Jewish Mothers in Israel

IMAJ 2001,3:419-421

Menashe N. Mukamel MD1,2, Yosef Weisman MD1,2, Raz Somech MD2, Zipora Eisenberg MSc1, Jacob Landman MD4, Itzhak Shapira MD1, Zvi Spirer MD2,3 and Uri Jurgenson MD2

'Bone Disease Unit and department of Pediatrics, Tel Aviv Sourasky Medical Center, and 3Leon Alkalay Chair in Pediatric Immunology, Sackler Faculty of Medicine, Tel Aviv University, and department of Pediatrics, Ma’anei Hayeshua Hospital, Bnei Brak, Israel

<100 IU of Vitamin D: 33% had <10 ng just after birth
400 IU of Vitamin D:13% had <10 ng

Chart of data by Dr. Grimes in 2021

Background: The modest clothing that Orthodox Jewish women wear exposes very little of their skin to sunlight. Under these conditions they may develop vitamin D deficiency, even in sunny Israel.

Objectives: To determine and compare the vitamin D nutritional status in Jewish orthodox mothers to that of nonorthodox mothers who live in the same metropolitan area in Israel.

Methods: 25-Hydroxyvitamin D was measured by competitive protein-binding radioassay in the sera of 341 Jewish Israeli mothers (156 orthodox and 185 non-orthodox). The sera were obtained 48-72 hours after childbirth during the late summer of 1998 and the spring of 1999.

Results: The mean (SD) serum concentration of 25-OHD was significantly (P< 0.002) lower (13.5 + 7.5 ng/ml) in the orthodox than in the non-orthodox mothers (18.6 + 9.6 ng/ml). Vitamin D deficiency (< 5 ng/ml) and insufficiency (< 10 ng/ml) were more common in the orthodox mothers (5.1% and 32.7% respectively) than in the non-orthodox mothers (2.7% and 13%, respectively). In subgroups of mothers supplemented with 400 units of vitamin D daily during pregnancy, vitamin D deficiency and insufficiency were less common (2.2% and 13%, respectively) in orthodox and non-orthodox mothers (0% and 8.1%, respectively). Vitamin D insufficiency was more common in the winter than in the summer only among nonorthodox mothers.

Conclusions: The high prevalence of vitamin D deficiency and insufficiency in Israeli mothers raises the question whether vitamin D supplements should be given to pregnant women in Israel, at least to orthodox mothers.

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