300000 IU injection of vitamin D3
The effect of intramuscular vitamin D (cholecalciferol) on serum 25OH vitamin D levels in older female acute hospital admissions.
Ir J Med Sci. 2010 Mar;179(1):57-61. Epub 2009 Aug 28.
Nugent C, Roche K, Wilson S, Fitzgibbon M, Griffin D, Nichaidhin N, Mulkerrin E.
Department of Medicine for the Elderly, University College Hospital Galway, Galway, Ireland. [email protected]
INTRODUCTION: Many studies have demonstrated the prevalence of vitamin D insufficiency in the older population.
OBJECTIVE: This study sought to determine whether supplementation with intramuscular vitamin D improved 25OH vitamin D levels significantly.
SUBJECTS: Ninety female inpatients aged over 65 years were assigned to receive 300,000 IU of intramuscular vitamin D3 (cholecalciferol) or no intervention.
METHODS: Baseline 25OH vitamin D and intact parathyroid hormone (iPTH) levels were taken and repeated 3 months after supplementation.
RESULTS: Patients who received treatment showed a significant improvement in 25OH vitamin D levels, from 25.5 to 81 nmol/L with 11% remaining deficient. No patient became hypercalcaemic after treatment.
CONCLUSIONS: Vitamin D deficiency is common throughout all age groups in the Irish population and particularly the older female population who have increased risk of osteoporosis and fractures. Intramuscular vitamin D significantly improves 25OH vitamin D levels compared to no treatment and may combat non-compliance with oral medication. PMID: 19714394
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