2260 diseases found to be fought by fully-activated Vitamin D (Calcitriol)

Created July 2024

Effects of vitamin D signaling in cardiovascular disease: centrality of macrophage polarization

Front Cardiovasc Med. 2024 Jun 25:11:1388025. doi: 10.3389/fcvm.2024.1388025

Anton Fliri 1, Shama Kajiji 1 founders of Emergent System Analytics

  • "Unlocking the power of proteomics, emergent illuminates a personalized path to health, where precision meets potential, and every individual's unique biology becomes the cornerstone of their well-being."

    A small portion of the proteins affected by Calcitriol

image

Among the leading causes of natural death are cardiovascular diseases, cancer, and respiratory diseases. Factors causing illness include genetic predisposition, aging, stress, chronic inflammation, environmental factors, declining autophagy, and endocrine abnormalities including insufficient vitamin D levels. Inconclusive clinical outcomes of vitamin D supplements in cardiovascular diseases demonstrate the need to identify cause-effect relationships without bias. We employed a spectral clustering methodology capable of analyzing large diverse datasets for examining the role of vitamin D's genomic and non-genomic signaling in disease in this study. The results of this investigation showed the following:

  • (1) vitamin D regulates multiple reciprocal feedback loops including p53, macrophage autophagy, nitric oxide, and redox-signaling;

  • (2) these regulatory schemes are involved in over 2,000 diseases.

Furthermore, the balance between genomic and non-genomic signaling by vitamin D affects autophagy regulation of macrophage polarization in tissue homeostasis. These findings provide a deeper understanding of how interactions between genomic and non-genomic signaling affect vitamin D pharmacology and offer opportunities for increasing the efficacy of vitamin D-centered treatment of cardiovascular disease and healthy lifespans.

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Additional diseases are probably fought by local (non-liver) generation of Calcitriol

Vitamin D affects 1289+ Genes, but even more proteins (in current study)

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