1289 genes changed with higher doses of Vitamin D - RCT

Disassociation of Vitamin D's Calcemic Activity and non-calcemic Genomic Activity and Individual Responsiveness: A Randomized controlled Double-Blind clinical Trial

Scientific RepoRtS | (2019) 9:17685 | https://doi.org/10.1038/s41598-019-53864-1

Arash Shirvani ,tyler Arek Kalajian, Anjeli Song & Michael F. Holick*

Randomized Controlled Trial lasting 24 weeks with 30 healthy adults of mixed race and sex * 291 genes improved expression by 2000 IU of vitamin D – RCT March 2013* Previous study by same authors 1. See also VitaminDWik* 54 genes significantly affected by Vitamin D (50,000 IU weekly for 12 weeks) – May 2021* Alzheimer’s is associated with all 7 of the genes which restrict vitamin D from getting to tissues – Sept 2018* Benefits of Vitamin D often limited by genes* Gene activation by high dose vitamin D - both quick and long term - April 2015Genes and Pregnancy* Pregnancy complications cut in half by 4,400 IU of Vitamin D - Sept 2017* 430 genes changed when 3,800 IU Vitamin D added in late second trimester – RCT May 2018* 5839 genes changed during pregnancy (many genes were related to Vitamin D) – Oct 2016Genes and MS* Multiple Sclerosis more likely if poor vitamin D genes - 22nd study – Aug 2017* 98 pcnt of genes that Vitamin D activates to reduce MS are also activated by Interferon -May 2013--- 1. Future Vitamin D gene studies could examine the gene changes:* to the 35+ genes associated with Vitamin D* Vitamin D Receptor, Vitamin D Binding Protein, etc.* If also use any of the 12+ Vitamin D Receptor activators - such as Resveratrol* Associated with the immune system* In tissues rather than just the blood* Gut genes* If start RCT with low levels of vitamin D* If use infrequent dosing (non-daily)* Many studies have found better treatment when Vitamin D is given less frequently* Due to genes?* If use UVB instead of Vitamin D* If the person has specific health problems* If have a poor vitamin D response* If add co-factors, e.g. Magnesium and Omega-3* If use a loading doseGraphic of the study results by Dr. Raimund von HeldenGraphic and web page in GermanTitle translated from German: Vitamin D commands over 1200 genes - but only at a vitamin D level of 78 ng / mlGraphics by GRH: 8X more genes changed--- 1. Vitamin D ReceptorVitamin D Receptor category has the following{include}10+ Vitamin D Receptor studies have overlaps to Health Problems* VDR & Diabetes  studies* VDR & Breathing  studies* VDR & Breast Cancer  studies* VDR & Cancer - general  studies* VDR & Obesity  studies* VDR &Multiple; Sclerosis  studies--- 1. Vitamin D Binding ProteinMS and Vitamin D Binding Protein: {category}TB and Vitamin D Binding Protein: {category}Breathing and Vitamin D Binding Protein: {category}Infant-Child and Vitamin D Binding Protein: {category}Pregnancy and Vitamin D Binding Protein: {category}

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The aims of this randomized controlled double-blind clinical trial were to assess the impact of vitamin D supplementation on calcium metabolism and non-calcemic broad gene expression by relating them to the individual's responsiveness to varying doses of vitamin D3. thirty healthy adults were randomized to receive 600, 4,000 or 10,000 IU/d of vitamin D3 for 6 months. Circulating parathyroid hormone (PTH), 25(OH)D, calcium and peripheral white blood cells broad gene expression were evaluated. We observed a dose-dependent increase in 25(OH)D concentrations, decreased PTH and no change in serum calcium. A plateau in PTH levels was achieved at 16 weeks in the 4000 and 10,000 IU/d groups. There was a dose-dependent 25(OH)D alteration in broad gene expression with 162, 320 and 1289 genes up- or down-regulated in their white blood cells, respectively. our results clearly indicated that there is an individual's responsiveness on broad gene expression to varying doses of vitamin D3. Vitamin D3 supplementation at 10,000 IU/d produced genomic alterations several fold higher than 4,000 IU/d even without further changes in PTH levels. Our findings may help explain why there are some inconsistency in the results of different vitamin D's clinical trials.

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