The CYP27B1 gene activates Vitamin D in the Kidney, Skin, Lungs, Brain, Eyes Breasts etc.
Poor CYP27B1 is assocated with COVID, Miscarriage, Lupus, Alz, Parkinson, MSA, Rickets
CYtochrome P450 family 27 subfamily B member 1 = 25-Hydroxyvitamin D3 1-alpha-hydroxylase
60 items in CYP27B1 category 332 articles in the Genetics 512 articles in Vitamin D Receptor 176 articles in Vitamin D Binding Protein - CYP27B1 and other genes are less activated in seniors
- CYP27B causes many health problems – March 2020
- Every Parkinson’s brain had a poor CYP27B1 gene
What can be done if have a poor CYP27B1
- Larger doses of Vitamin D
- More Bio-available: Gut-friendly form, Topical form, taken with fatty meal, taken with evening meal
- Additional sources: UV
- Increase Vitamin D metabolism: additional Magnesium, Omega-3
- All cytochrome P450 enzymes require Mg++ as a cofactor
- Increase the amount of Vitamin D in the blood that gets to cells: increase activation of VDR
Vitamin D blood test misses CYP27B1 and other genes
Here are all of the CYP27B1 articles
- wiki page:
- COVID maximum downregulation of Vitamin D receptor and CYP27B1 resulted in death - Feb 2024
- Miscarriage (Recurrent Spontaneous) associated with poor CYP27B1 gene - Jan 2024
- Vitamin D and it’s related genes regulate the immune system – Aug 2023
- 12 Vitamin D genes (Most are not noticed by blood test) – Sept 2021
- Cervical Cancer is prevented by Vitamin D, and treated if caught early (genes are important) – May 2023
- Gestational Diabetes and Vitamin D - many studies
- Response to Vitamin D - many studies
- Vitamin D genes may be more important than (25(OH)D) to orthopedics – Review Dec 2022
- Lupus associated with another poor vitamin D gene (CYP27B1 – in addition to low Vitamin D and poor VDR) – Aug 2022
- Neuro problems (AD, PD, MSA) associated with poor vitamin D genes (CYP27A1, CYP27B1) – Sept 2022
- An ocular disease can be associated with low vitamin D and 1 of 5 poor vitamin D genes – June 2022
- Vitamin D genes – Review June 2022
- Vitamin D may reduce autism by increasing nitric oxide – June 2022
- Vitamin D metabolism and genes as of Nov 2019
- Poor vision associated with poor Vitamin D or poor Vit. D genes – June 2022
- Poor Vitamin D gene activation that results in rickets etc, (CYP27B1: 1 in 30 people in a region of Quebec) – May 2022
- Poor Vitamin D gene activation that results in rickets etc, (CYP27B1: 1 in 30 people in a region of Quebec) – May 2022
- Better handgrip strength if some good vitamin D genes (or if supplement) – April 2022
- Gene variants can reduce Vitamin D response by 1.7X (14,000 IU daily, Multiple Sclerosis) – Dec 2021
- Every Parkinson’s brain had a gene modification that limited how much vitamin D was available (CYP27B1) – Feb 2022
- Vitamin D Metabolite Profiling and genes (CYP24A1, CYP27B1)– Nov 2021
- Breast Cancer, Vitamin D, and genes – Welsh Nov 2021
- Vitamin D levels in cells, not blood, is important (IVF follicular fluid in this case) – Aug 2021
- Breasts process Vitamin D and change gene activation, might prevent breast cancer if given more Vit. D – July 2021
- COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021
- Mucosal membranes (mouth, lungs, nose, intestines, etc) can activate Vitamin D – July 2020
- Vitamin D genes are important, update – Sept 2020
- Vitamin D in the blood encounters many restrictions in getting to the cells – Sept 2020
- Parathyroid increase with age associated with worsening Vitamin D genes – April 2020
- Infant and child immunity depends on Vitamin D and two Vitamin D genes – Review April 2020
- Gene mutations which restrict Vitamin D activation (CYP27B1) results in many health problems – March 2020
- Vitamin D genes vary with UVB in Europe, Africa, Asia – March 2020
- Vitamin D may be a magic bullet for the cells (not based on Vitamin D blood tests) – Jan 2020
- Does survival of the less fit mean less health (poor genes may be inherited)
- Eye vitamin D may not be associated with blood VitD, but is associated with CYP27B1 and CYP24A1 – Nov 2019
- Acute Coronary Syndrome is associated with poor Vitamin D genes (CYP27B1, CYP24A1) – Nov 2019
- Vitamin D deficiency is associated with 35 genes, only 7 of are commercially tested – Nov 2019
- CYP27B1
- Increased risk of various cancers if poor vitamin D genes (Binding Protein and CYP27B1) - Sept 2019
- ALS associated with poor CYP27B1 gene (not seen by Vitamin D blood test) – May 2019
- Body may change gene activation if more Vitamin D is needed by tissue (Schiz. in this case) – Oct 2018
- Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018
- Vitamin D gene expression varies with Epileptic age – March 2018
- Brain cells can probably activate Vitamin D without liver or kidney (at least in rats) – Sept 2017
- Brain may deal with all forms of Vitamin D (rat brain) – Sept 2017
- Review of 11 Vitamin D genes – Nov 2017
- Glucocorticoid treatment reduces Vitamin D getting to cells via 3 or 4 genes
- Miscarriages strongly associated with poor placental, decidua gene which locally activates Vitamin D – Dec 2016
- Genes which regulate active vitamin D worsen with age – Oct 2016
- Miscarriage 70 percent more likely if low vitamin D (see also data on CYP27B1) – May 2016
- Lungs with cystic fibrosis fail to activate vitamin D (poor CYP27B) – Feb 2016
- Lung cancer – reduced deaths if have a good vitamin D gene (CYP27B1) – Feb 2015
- Colon cancer 30 percent more likely if problems with Vitamin D genes CYP24A1 or CYP27B1 – Nov 2015
- UVB increases vitamin D even if poor kidney by changing CYP27B1 genes in skin – Dec 2013
- UVB effects on genes of those with and without Psoriasis – April 2014
- CYP27B1 gene decreases kidney production of active vitamin D – Feb 2013
- Genes such as CYP27B1, CYP24A1 and Vitamin D – JAMA Nov 2012
- Vitamin D levels are strongly associated with genes: overview of twin studies – Nov 2012
- Mutation of Vitamin D gene (CYP27B1) is strongly tied to MS – Dec 2011
- Prostate Cancer – Vitamin D – CYP27B1 – CYP24 – June 2011
See also web
- Gene therapy for CYB27B1extended the lives of mice with acute myeloid leukemia - compared to placebo
- A novel vitamin D gene therapy for acute myeloid leukemia
- Behind paywall DOI: 10.1016/j.tranon.2020.100869 Sept 2020
- Higher risk of Atrial fibrilation of poor CYP27B1
- Vitamin D Status in Patients with Atrial Fibrillation and Heart Failure - Is there a Link? - June 2021
- Details are behind a paywall @ DOI: 10.7754/Clin.Lab.2020.200902
CYP27B1 Associations: Genetics 37, Vitamin D Receptor 33, Vit D Binding Protein 21, Cancer - Breast 4, Pregnancy 4, Vision 3 Cognitive 3, UV 3
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