Vitamin D Supplementation Ameliorates Severity of Major Depressive Disorder.
J Mol Neurosci. 2019 Dec 13. doi: 10.1007/s12031-019-01461-2
Alghamdi S1,2, Alsulami N3, Khoja S3,4, Alsufiani H3,4,5, Tayeb HO6, Tarazi FI7.
Weekly 50,000 IU
Non-Daily Intervention of Vitamin D for Depression
- Yet another study confirms Depression is treated by weekly Vitamin D – RCT Dec 2019
- Depression decreased after vitamin D (50,000 IU weekly to elderly in the case) – RCT Oct 2019
- Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018
- Vitamin D depression RCT canceled: too many were taking Vitamin D supplements, etc. Feb 2018
- Depression in adolescent girls reduced somewhat by 50,000 IU weekly for 9 weeks – July 2017
- 40,000 IU vitamin D weekly reduced depression in many obese subjects – RCT 2008
- 50,000 IU Vitamin D weekly Improves Mood, Lowers Blood Pressure in Type 2 Diabetics – Oct 2013
Depression category summary
- Low vitamin D is associated with most types of depression, Including: Seasonal Affective Disorder. manic depression, bipolar disorder, dysthymia, Depression during/after pregnancy, Seniors, Suicide
- Seasonal Affective Disorder is treated by both bright light and Vitamin D because both make serotonin
- Supplementing with Vitamin D (or getting more sun) decreases most types of depression as well as drugs
- Omega-3, Magnesium, and St. Johns' Wort also decrease depression
Speculate that some combination (Vit D, Omega-3, Mg, St John's) will decrease depression even more - Omega-3 and Vitamin D each treat many mental health problems - April 2018
- There are
215 items in the Depression category in Vitamin D Life Better than Daily category listing has
18 items 50,000 IU every two weeks proven to fight
Diabetes + Heart Failure + Chronic Pain + Depression + Autism + Breast Cancer + Colon Cancer + Prostate Cancer + Preeclampsia + Premature Birth + Falls + Cognitive Decline + Respiratory Tract Infection + Influenza + Tuberculosis + Chronic Obstructive Pulmonary Disease + Lupus + Inflammatory Bowel Syndrome + Urinary Tract Infection + Poor Sleep + Weight Loss + Growing Pain + Multiple Sclerosis + PMS + Schizophrenia (25 problems)
 Download the PDF from Sci-Hub via Vitamin D Life
Major depressive disorder is a serious neuropsychiatric disease that leads to significant impairment in social functioning and increased morbidity and mortality. Low vitamin D (25-OH D) levels have been hypothesized to contribute to the pathophysiology of MDD. To investigate the therapeutic role of vitamin D in MDD, we recruited 62 male and female patients diagnosed with MDD and randomized them into two groups: the first group (49 patients) received vitamin D supplementation as cholecalciferol vitamin D3 (50,000 I.U.) for 3 months, in addition to standard of care (SOC) which included pharmacological treatment and psychological support, and the second group (13 patients) received only SOC without vitamin D supplementation for 3 months. The Beck depression inventory (BDI) scale was used to assess the severity of MDD symptoms. Immunoassays were utilized to determine levels of serum vitamin D3 and serotonin in all patients. The results showed significant gender differences; female patients showed the most improvement in their depressive symptoms after 3-month vitamin D supplementation. Females with moderate, severe, and extreme depression had significantly lower BDI scores after vitamin D treatment (p < 0.05). Among males, only those diagnosed with severe depression showed significant improvement in their BDI scores (p < 0.05). Serum serotonin levels were significantly increased after vitamin D supplementation compared to baseline in both male and female patients. No significant changes in other biochemical parameters were detected between the two groups. These findings suggest that vitamin D supplementation may ameliorate symptoms of MDD, particularly in females, via a serotonin-dependent mechanism.
Yet another study confirms Depression is treated by weekly Vitamin D – RCT Dec 2019753 visitors, last modified 15 Dec, 2019, This page is in the following categories (# of items in each category)Depression215 Intervention 639 Intervention - non daily 193 Better than daily 18 Attached files
ID Name Comment Uploaded Size Downloads 13152 Depression 50,000 male.jpg admin 15 Dec, 2019 16:05 26.00 Kb 219 13151 Depression 50,000.jpg admin 15 Dec, 2019 16:05 25.80 Kb 250 13150 depression.pdf PDF 2019 admin 15 Dec, 2019 16:04 459.59 Kb 130 See any problem with this page? Report it (FINALLY WORKS)