Vitamin D receptor substitutes are being patented – Sept 2015

Therapeutic application of vitamin D receptor ligands: an updated patent review.

Expert Opin Ther Pat. 2015 Sep 24:1-11. [Epub ahead of print]
Takada I1, Makishima M1.
1a Nihon University School of Medicine, Division of Biochemistry, Department of Biomedical Sciences , 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan +81 3 39 72 81 99 ; +81 3 39 72 81 99 ; makishima.makoto at nihon-u.ac.jp.

INTRODUCTION:
The vitamin D receptor (VDR) is a promising drug target in the treatment of cancer, autoimmune disease, inflammation, infection and cardiovascular disease, as well as bone and mineral disorders. Although many VDR ligands have been developed and shown to activate VDR in vitro and in vivo, including vitamin D derivatives and non-secosteroidal compounds, a principal adverse effect of hypercalcemia has limited their clinical application.

Areas covered: We summarize recent patent activity regarding VDR ligands, including vitamin D derivatives, non-secosteroidal compounds and tissue-selective prodrugs, alongside their therapeutic applications. The potential for use of VDR ligands in the treatment of

• hepatic fibrosis,
• pancreatic fibrosis and
• neuronal disease

is also reviewed.
Expert opinion: Several VDR ligands have been shown to have increased therapeutic efficiency in experimental models of

• cancer,
• inflammation and
• cardiovascular disease,

and to exhibit function-selective and/or tissue-selective activity. The underlying molecular and pharmacological mechanisms remain to be elucidated. Further studies, both basic and applied, should make successful VDR-targeting therapy possible.

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See also Vitamin D Life

• Vitamin D analogs – 25 years of trying to trying to patent vitamin D – April 2014
• Who said vitamin D could not be patented by Vitamin D Life

Vitamin D Receptor category has the following

384 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )

A poor VDR increases the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement   Sun, Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D in the cells
13) Sulfroaphone and perhaps sulfur	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR