First 3 sections clipped from Vitamin D Receptor Gene: Activation, Calcitriol, Benefits
Natural Ways to Increase Calcitrol and VDR
- Exercise 38 – increases calcitriol, but not aerobic exercise 39.
- RXR (and retinol) is needed to produce proteins with the VDR. 1,25D3 binds to the VDR, which then combines with RXR to activate gene expression. (Not all VDR dependent genes need RXR.)
- Parathyroid hormone (PTH) – increases Calcitriol/1,25 D3 40 and PTH-related peptide 41,
- SIRT1 – potentiates VDR 42, 43 – acetylation of VDR lessens 1,25D/VDR signaling. SIRT1 increased the ability of VDR to associate with RXR.
- PGC-1a 44 – potentiates VDR. It is a coactivator of the VDR, but it still needs 1,25D3.
- Dopamine 45
- Bile – specifically Lithocholic acid orLCA 46, The VDR evolved from its ancient role as a detoxification nuclear receptor. LCA is produced from the gut bacteria (metabolizing liver-derived chenodeoxycholic acid). LCA travels to the colon, where the VDR binds to LCA or 1,25 D and activates the CYP3A4 and SULT2A genes facilitate disposal from the cell via the ABC efflux transporter 47.
- Omega-3: DHA, EPA 47, – Fish oil/DHA
- Omega-6: γ-Linolenic acid, Arachidonic acid 47,
- Curcumin 1 – Curcumin is more active than LCA/Bile in driving VDR-mediated transcription and that it binds to VDR with approximately the same affinity as LCA.
- Resveratrol 42 – Potentiates VDR by: (1) potentiating 1,25D binding to VDR; (2) activating RXR; (3) stimulating SIRT1
- Forskolin 40 – increases 1,25D3 from 25D3 in-vitro
- Gamma Tocotrienol 47 – Tocotrienols or Tocopherols (IHERB)
- Vitamin E/alpha-tocopherol 47 – doesn’t compete with calcitriol for the VDR.
- Dexamethasone 47 – doesn’t compete with 1,25
- Interferon-gamma – IFN-γ treatment inhibited 1,25D3 induction of 24-hydroxylase, the enzyme that breaks down 1,25 D3. This means 1,25D3 increased. (Technical: IFNy did not change the base level activity of the promoter, or change 1,25 D binding to the VDR or nuclear VDR levels. IFN-γ impairs VDR-RXR binding to VDRE through a Stat1-mediated mechanism) 48.
- Estradiol increases VDR expression 49, 50 and calcitriol levels 51.
- Phytoestrogens 52
- Testosterone 53
- Prostaglandins
- Bisphosphonates
DHA, EPA, linoleic acid and arachidonic acid are all 10,000X less capable than 1,25 D3 at activating the VDR 47.
Curcumin is 1,000X less capable than 1,25 D3 in inducing VDR gene expression 47.
Curcumin and bile have a similar binding ability to the VDR and similar levels of gene expression 47.
Curcumin, Bile, DHA, EPA, Arachidonic acid all compete with 1,25 D3 for binding. Dexamethasone and alpha-tocopherol don’t compete 47.
A natural question to pose would be that if these are competitive binders and have a much lower binding capacity for the VDR, are they of use? The answer seems to be yes.
High concentrations of PUFAs could occur in select cells or tissues and exert bioactivity 47.
Excess Bile/LCA given to rats caused the same effect that 1,25D3 would cause (in particular calcium transport activation) 47.Kidney glandular might contain some 1,25 vitamin D.
What Inhibits The Vitamin D Receptor (VDR) or Calcitriol
- Caffeine decreases VDR production 54
- Cortisol/Glucocorticoids decreases VDR production 25
- Prolactin 55
- Thyroid hormones repress VDR activation 56
- TGF-beta reduces the activation of VDR/RXR combination, which results in VDR-mediated gene expression 57
- TNF 58 (inhibits osteocalcin interaction with VDR, but not osteopontin)
- Corticosteroids decrease calcitriol 59
- Phosphatonin, Ketoconazole, Heparin, and Thiazides decrease calcitriol 59
- Ubiquitin 60 – autophagy stops this
Pathogens That Inhibit The Vitamin D Receptor
Many pathogens inhibit some aspect of the vitamin D system – either the VDR, the ability of molecules to bind to it or the ability of VDR to cause gene expression. These are some examples, but I’m sure I haven’t covered all of them known to the body of science.
- P. aeruginosa (often hospital acquired). Produces “Sulfonolipid ligand capnine” 61. Antibiotics don’t work well 62.
- H. pylori (responsible for stomach ulcers). 50% of the global population has this. Produces “Sulfonolipid ligand capnine” 61.
- Lyme/Borrelia – Live Borrelia reduces VDR by 50 times (in monocytes) and “dead” Borrelia reduces it by 8 times 63
- This could explain why people develop autoimmune conditions after Lyme infection.
- Tuberculosis – Reduces VDR 3.3-fold 64
- “Gliding” biofilm bacteria have been shown to create Capnine – Capnine (Cytophaga, Capnocytophaga, Sporocytophaga, and Flexibacter)
- Chlamydia (trachomatis)
- Shigella – bacteria in stool and causes intestinal problems and diarrhea. It increases Caspase-3, which is a protein which breaks apart the VDR structure and thus limits the ability of VDR to perform gene transcription 65.
- Mycobacterium leprase – produces mir-21 to target multiple genes associated with the VDR 64.
- Epstein-Barr virus (EBV) – Decreases VDR by a factor of about five 66 EBV also blocks the ability of VDR to produce products 67.
- HIV – binds to the VDR 68 and inhibits conversion to active D 69.
- Aspergillus fumigatus – In cystic fibrosis patients, the fungus A. fumigatus has been shown to secrete gliotoxin, a toxin which dose-dependently decreases VDR.
- Cytomegalovirus – CMV decreases VDR 2.2 fold 70.
- Hepatitis C virus – Inhibits CYP24A1, the enzyme responsible for breaking down excess 1,25-D 71
When bacterial products block the VDR, less of the CYP24A1 is produced, which results in excess active vitamin D – as is the case in many autoimmune conditions.
See also VDR and Calcitriol in Vitamin D Life
The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019
Vitamin D Receptor category has the following
512 |
studies in Vitamin D Receptor categoryVitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
See also: 47 |
studies in the Resveratrol categoryIt appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems
Health problems include: Autoimmune (19 |
studies), Breast Cancer (22 |
studies), Colon Cancer (13 |
studies), Cardiovascular (23 |
studies), Cognition (16 |
studies), Diabetes (24 |
studies), Hypertension (9 |
studies), Infant (21 |
studies), Lupus (6 |
studies), Metabolic Syndrome (4 |
studies), Mortality (4 |
studies), Multiple Sclerosis (12 |
studies), Obesity (16 |
studies), Pregnancy (24 |
studies), Rheumatoid Arthritis (10 |
studies), TB (8 |
studies), VIRUS (36 |
studies), Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Increased risk associated with a poor Vitamin D Receptor
Note: Some diseases reduce VDR activation
those with a * are known to decrease activation
Vitamin D Receptor and Cancers
81+ Vitamin D Receptor pages with CANCER in the title
This list is automatically updated
Items found: 86
Title | | Modified |
Vitamin D Receptor (Cancers OR Viruses) - many studies | | 02 Mar, 2024 |
Oral Cancer and Vitamin D and VDR - several studies | | 11 Feb, 2024 |
Breast Cancer risk reduced if consume butyrate - Dec 2023 | | 23 Jan, 2024 |
An activated Vitamin D Receptor fights Autoimmune Diseases, Infections, Cancers, etc. – Dec 2023 | | 13 Jan, 2024 |
Cervical Cancer is prevented by Vitamin D, and treated if caught early (genes are important) – May 2023 | | 27 May, 2023 |
Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022 | | 06 Dec, 2022 |
Breast cancer spreads to bone if poor vitamin D Receptor (no surprise) – Oct 2022 | | 31 Oct, 2022 |
2X more Thyroid Cancer malignancy if less than 15 ng of vitamin D – June 2012 | | 16 Sep, 2022 |
Cancers are associated with low vitamin D, poor vaccination response and perhaps poor VDR – July 2022 | | 15 Aug, 2022 |
Poor prognosis of solid childhood cancers 14.7 X more likely with a poor Vitamin D Receptor – July 2022 | | 27 Jul, 2022 |
Breast Cancer, Vitamin D, and genes – Welsh Nov 2021 | | 09 Feb, 2022 |
How cancer is fought by Vitamin D (Ovarian this time) - Feb 2020 | | 01 Nov, 2021 |
Lung Cancer is up to 7 X more deadly if poor vitamin D genes – Oct 2021 | | 25 Oct, 2021 |
Cancers and Vitamin D Receptors, including change with race – Feb 2021 | | 24 Oct, 2021 |
Breast Cancer reduces receptor and thus blocks Vitamin D to the cells – several studies | | 18 Oct, 2021 |
After lactation Vitamin D levels are low, increased risk of Breast Cancer, vitamin D should decrease risk – Aug 2021 | | 20 Aug, 2021 |
Breasts process Vitamin D and change gene activation, might prevent breast cancer if given more Vit. D – July 2021 | | 10 Jul, 2021 |
Oral Cancers - increased risk if low vitamin D or poor vitamin D genes | | 22 Jan, 2021 |
Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021 | | 15 Jan, 2021 |
Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020 | | 09 Dec, 2020 |
Colorectal Cancer Patients 2.4 X more likely to have poor Vitamin D receptors (less D to cells) – April 2020 | | 02 May, 2020 |
Colorectal cancer linked to poor Vitamin D Receptor (yet again) – Jan 2020 | | 22 Jan, 2020 |
8 ways that Cancer might be prevented by Vitamin D - June 2019 | | 26 Dec, 2019 |
Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019 | | 14 Dec, 2019 |
Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019 | | 15 Nov, 2019 |
Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016 | | 09 Nov, 2019 |
Cancer is leading cause of death - Vitamin D and Receptor activators help | | 09 Nov, 2019 |
Melanoma cancer growth slowed by increased Vitamin D Receptor (yet again) – Oct 2019 | | 06 Nov, 2019 |
Breast cancer associated with Vitamin D Receptor (14th study) – Oct 2019 | | 19 Oct, 2019 |
Colorectal Cancer risk increases when genes reduce the vitamin D levels – Aug 2019 | | 23 Aug, 2019 |
Breast Cancer death 1.8 X more likely if poor Vitamin D Receptor – April 2019 | | 29 Jul, 2019 |
Multiple Myeloma (blood cell cancer) treated by vitamin D - many studies | | 14 Jun, 2019 |
Blood cell cancer is associated with a 3X worse Vitamin D Receptor – June 2019 | | 14 Jun, 2019 |
Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis June 2019 | | 13 Jun, 2019 |
After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor – June 2019 | | 04 Jun, 2019 |
Effects of Resveratrol against Lung Cancer in mice – Nov 2017 | | 28 Apr, 2019 |
The Role of Resveratrol in Cancer Therapy – Dec 2017 | | 27 Apr, 2019 |
Good Vitamin D receptor reduced bladder cancer and cisplatin deaths – April 2019 | | 11 Apr, 2019 |
A poor Vitamin D Receptor is associated with many cancers (oral cancer in this case) – Jan 2019 | | 26 Mar, 2019 |
Breast Cancer and Vitamin D review – March 2018 | | 17 Mar, 2019 |
Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018 | | 15 Mar, 2019 |
Women with Breast Cancer were 16.9 times more likely to have a poor Vitamin D Receptor – Jan 2019 | | 11 Feb, 2019 |
Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018 | | 09 Dec, 2018 |
Ovarian Cancer risk reduced if higher vitamin D, more UVB, or better vitamin D receptor – Nov 2018 | | 10 Nov, 2018 |
Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018 | | 01 Nov, 2018 |
Brain cancer in 175 countries related to low UVB and low vitamin D – Oct 2010 | | 03 Oct, 2018 |
Pancreatic Cancer – live a year longer if have high vitamin D and good Vitamin D Receptor – Aug 2018 | | 15 Aug, 2018 |
Endometriosis, Endometrial Cancer, and poor Vitamin D or Receptor – Aug 2018 | | 08 Aug, 2018 |
Risk of colon cancer increases in mice with no Vitamin D receptor in colon - July 2018 | | 07 Jul, 2018 |
Vitamin D receptor is essential for both normal and cancerous cells in the lab – June 2018 | | 16 Jun, 2018 |
Active Vitamin D reduces Ovarian Cancer stem cells growth by 4X (via Vitamin D receptor in lab rat) – March 2018 | | 28 Mar, 2018 |
Two chemicals increase the Vitamin D receptor and decrease the growth of breast cancer cells in the lab - March 2018 | | 17 Mar, 2018 |
Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017 | | 14 Dec, 2017 |
Nonmelanoma Skin Cancer 2X more likely if poor Vitamin D Receptor – Oct 2017 | | 19 Oct, 2017 |
Cancer and the Vitamin D Receptor, a primer – Sept 2017 | | 01 Oct, 2017 |
Thyroid Cancer rate has increased 3X in 3 decades, Vitamin D Receptor decreases, Calcium increases – Aug 2017 | | 26 Aug, 2017 |
Advanced Colon Cancer risk is doubled or halved with 1000 IU of Vitamin D, depends on Vitamin D Receptors – RCT May 2017 | | 19 Aug, 2017 |
Cancer risks and Vitamin D Receptors – association is unclear – 2017 | | 19 Aug, 2017 |
Increased Breast Cancer metastasis if low vitamin D or poor VDR – Feb 2016 | | 09 Aug, 2017 |
Colon Cancer survival 3.1 X less likely if poor Vitamin D Receptor – Aug 2017 | | 02 Aug, 2017 |
Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene – July 2017 | | 27 Jul, 2017 |
Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014 | | 25 Jul, 2017 |
Gastric Cancer 2.7 X more likely if poor Vitamin D Receptor (Chinese) – 2015 | | 15 Jun, 2017 |
Skin Cancers, Vitamin D, Vitamin D Receptor and Genes – Jan 2015 | | 17 Mar, 2017 |
Prostate cancer in black men is 1.6 times more likely if a poor Vitamin D Receptor – Feb 2017 | | 06 Mar, 2017 |
2X more likely to survive a form of esophageal cancer in China if have good vitamin D receptor – Feb 2017 | | 04 Mar, 2017 |
Urinary Bladder Cancer survival is associated with vitamin D receptor: 14 months vs 53 months – Oct 2015 | | 02 Mar, 2017 |
Vitamin D receptor as a target for breast cancer therapy (abstract only) – Feb 2017 | | 01 Mar, 2017 |
Ovarian Cancer 5.8 X more likely if both low vitamin D and Fok1 gene change – May 2013 | | 27 Feb, 2017 |
Vitamin D receptor may suppress skin cancer – Dec 2013 | | 27 Jan, 2017 |
Aggressive Prostate Cancer in blacks with low vitamin D – 7X more likely if added Calcium – Jan 2017 | | 28 Dec, 2016 |
Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016 | | 06 Dec, 2016 |
Vitamin D, Vitamin D Receptor and Cancer – Nov 2016 | | 05 Dec, 2016 |
High PSA readings with Prostate Cancer 4 times more likely if poor Vitamin D receptor – March 2016 | | 14 Nov, 2016 |
2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013 | | 14 Nov, 2016 |
Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014 | | 12 Nov, 2016 |
10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012 | | 23 Sep, 2016 |
Vitamin D Receptor role in Autoimmune Diseases and or cancers – Nov 2013 | | 17 Mar, 2016 |
Skin cancer 20 percent more likely with some Vitamin D receptor gene polymorphisms – Oct 2015 | | 06 Jan, 2016 |
Pancreatic Cancer treatment by calcipotriol (a synthetic vitamin D) improves outcome by 57 percent – Sept 2014 | | 13 Dec, 2015 |
Poor Bladder Cancer survival associated with poor Vitamin D receptor – Oct 2015 | | 18 Oct, 2015 |
Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015 | | 03 May, 2015 |
Free vitamin D (VDR) may be more important than total for bladder cancer – March 2013 | | 06 Jan, 2014 |
Genes breast cancer and vitamin D receptor - Sept 2010 | | 08 Jul, 2013 |
Breast Cancer incidence change by 40 percent with vitamin D receptor genes – Oct 2012 | | 08 Jul, 2013 |
Vitamin D receptor in breasts and breast cancer vary with race – March 2013 | | 08 Jul, 2013 |
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