Low Vitamin D associated 1.8X increased risk of COVID-19 death in hosptial – meta-analysis Nov 4, 2020

Low serum vitamin D level and COVID-19 infection and outcomes, a multivariate meta-analysis

Jie Chen, Lixia Xie, Ping Yuan, Jianyong Ma, Peng Yu, Chunhua Zheng, Xiao Liu
Preprint Oct 27 doi: https://doi.org/10.1101/2020.10.24.20218974

Objective: This study aimed to determine whether serum vitamin D is independently associated with COVID-19 infection and outcomes in patients with COVID-19.

Methods: We identified relevant studies by searching the PubMed, Embase, and medRxiv databases from December 2019 to October 1, 2020. Odds ratios (ORs) were pooled using random-effects models. Only reports with multivariate adjusted results were included to avoid the impact of potential confounding factors.

Results: A total of six studies with 377,265 patients were identified. Overall, in the categorical analysis, a low serum vitamin D level was associated with an increased risk of COVID-19

• infection (OR: 1.47, 95% CI: 1.09- 1.97, I2=81%),
• hospitalization (OR: 1.83, 95% CI: 1.22-2.74, I2=0%),

but not in-hospital death (OR: 2.73, 95% CI: 0.27-27.61). Notably, when vitamin D level was analyzed as a continuous variable, each 5 ng/ml increase in vitamin D level was not associated with any increased risk of COVID-19 infection (OR: 1.04, 95% CI: 0.96-1.12, I2=74%) or in-hospital death (OR: 1.02, 95% CI: 0.93-1.12).

Conclusions: Low serum vitamin D is associated with an increased risk of COVID-19 infection and hospitalization. In-hospital death showed a tendency to be increased in COVID-19 patients with low vitamin D levels. The ongoing clinical trials for evaluation of vitamin D supplementation will be key to the validation of this adjunctive treatment for COVID-19 patients.

 Download the final Nov 4 peer-reviewed version from sci-hub Vitamin D Life
     Download the previous Oct 27 pre-print version from Vitamin D Life

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See also: COVID-19 1.7X more likely to be severe if low Vitamin D - meta-analysis Oct 2020

COVID-19 treated by Vitamin D - studies, reports, videos

As of Dec 1: 36 trials, 4 trial results, 3 meta-analyses, 32 observations, 15 recommendations, 35 associations, 80 speculations, 29 videos

Top Vitamin D and COVID-19 recent updates

• Evidence of Vitamin D fighting COVID-19 etc. - 4,000 IU if less than 20 ng (UK) – Dec 1, 2020
• 1.4X less risk of COVID-19 if had taken some Vitamin D (a US yes-no survey) – Nov 30, 2020
• COVID-19 and Vitamin D: Health Authorities do not understand risk-reward – Nov 2020
• c19study.com/d has excellent synopsis of Vitamin D and COVID studies
  •   click to see 3 weeks in Nov 2020
• COVID-19 – Putative Roles of Vitamin D – Nov 2020
• Fight COVID-19 without drugs or vaccines, Vitamin D is the single most-studied way – Nov 2020
• Clinical trials are proving that Vitamin D fights COVID-19 in hospitals by Vitamin D Life
• Vitamin D should fight COVID-19 (but Irish Consortium recommends only 1,000 IU) – Nov 21, 2020
• Hospital COVID-19 observation: 7X more likely to live if more than 20 ng of vitamin D– Nov 19, 2020
• Severe COVID-19 not fought by vitamin D when given too late - RCT Nov 18, 2020
• Higher vitamin D associated with fewer cases and deaths in India Nov 2020
  • 
• COVID-19 defeated 3x faster by 420,000 IU Vitamin D nanoemulsion – RCT Nov 12, 2020
• 2X fewer COVID-19 deaths observed if infrequent vitamin D (2X more deaths if daily dose) – ClinicalTrial Oct 20, 2020
• Vitamin D fighting COVID-19 meets all Bradford Hill Criteria - Nov 2020
• French National Academy recommended 100,000 IU of Vitamin D to elderly to fight COVID-19 - May 2020
• Chinese COVID-19 study – 80 pct of severe cases had low Vitamin D, all asymptomatic cases had OK Vit D – Oct 13, 2020
• Vitamin D and COVID-19 - observational studies found it helps, never hurts - Campbell Oct 31, 2020
• Low Vitamin D associated 1.8X increased risk of COVID-19 death in hosptial – meta-analysis Nov 4, 2020
• COVID-19 lung death 4X more likely in Iran if less than 25 ng of vitamin D – Oct 30, 2020
• Evidence Regarding Vitamin D and Risk of COVID-19 and its Severity - Oct 27, 2020
• COVID-19 patients who happened to be taking Vitamin D did much better – Oct 27,2020
• 9X COVID-19 survival in nursing home if had 80,000 IU dose of vitamin D in previous month – Oct 2020
• COVID-19 fought by Vitamin D in 43 studies - Oct 15, 2020
• 15 studies indicating that Vitamin D fights COVID-19 - Dr. Grimes Oct 9, 2020
• 32X more likely to have severe-critical COVID-19 in Turkish hospital if Vitamin D deficient – Oct 5, 2020
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• Vitamin D Cuts SARS-CoV-2 Infection Rate by Half Mercola Sept 28
  • 47% lower SARS-CoV-2 positivity rate if > 50 ng vs < 20 ng
  • 58% lower risk of testing positive for SARS-CoV-2 if > 30 ng vs < 30 ng
  • 2X higher risk of hospitialization if <30 ng
  • ICU patients got semi-activated Vitamin D - death rate dropped to 2% from 50%
• Virtually no COVID-19 cases in countries having more than 30 ng of Vitamin D - Sept 17, 2020
  • 
• Studies on Vitamin D and COVID-19 (11 categories) - Sept 20, 2020
• Rate of COVID-19 test positive is 40 pcnt lower if high vitamin D (192,000 people) - Holick Sept 2020
  • 
• Vitamin D in Prevention and Treatment of COVID-19 (16 reasons) – Sept 1, 2020

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Many clinical trials are underway which are testing Vitamin D to fight COVID-19

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