Urinary Tract Infection and Vitamin D – several studies

7+ Vitamin D Life pages have URINARY TRACT INFECTION in the title

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UTI rate cut in half by Vitamin D (20,000 IU weekly) – RCT June 2016

Prevention of urinary tract infections with vitamin D supplementation 20,000 IU per week for five years. Results from an RCT including 511 subjects
Infectious Diseases, Volume 48, 2016 - Issue 11-12 https://doi.org/10.1080/23744235.2016.1201853
Rolf Jorde,Stina T. Sollid,Johan Svartberg,Ragnar M. Joakimsen,Guri Grimnes & Moira Y. S. Hutchinson

Background: In observational studies vitamin D deficiency is associated with increased risk of infections, whereas the effect of vitamin D supplementation in randomized controlled trials is non-conclusive.

Methods: Five hundred and eleven subjects with prediabetes were randomized to vitamin D3 (20,000 IU per week) versus placebo for five years. Every sixth month, a questionnaire on respiratory tract infections (RTI) (common cold, bronchitis, influenza) and urinary tract infection (UTI) was filled in.

Results: Mean baseline serum 25-hydroxyvitamin D (25(OH)D) level was 60 nmol/L. Two hundred and fifty-six subjects received vitamin D and 255 placebo. One hundred and sixteen subjects in the vitamin D and 111 in the placebo group completed the five-year study. Eighteen subjects in the vitamin D group and 34 subjects in the placebo group reported UTI during the study (p < 0.02), whereas no significant differences were seen for RTI. The effect on UTI was most pronounced in males. The effect of vitamin D on UTI was unrelated to baseline serum 25(OH)D level.

Conclusion: Supplementation with vitamin D might prevent UTI, but confirmatory studies are needed.
 Download the PDF from Sci-hub via Vitamin D Life

Response to 20,000 IU weekly for years was 49 ng/mL

Cited 61 times as of Aug 2024

More children with UTIs have low Vitamin D (4.5 X) or Zinc (3.4 X) - April 2024

Serum Vitamin D and Zinc Levels in Children with Urinary Tract Infection without Confounding Factors: A Case-Control Study
Med J Islam Repub Iran . 2024 Apr 2:38:36. doi: 10.47176/mjiri.38.36. eCollection 2024.
Mohsen Seifollahi 1, Marzieh Heidarzadeh Arani 2, Rozita Hoseini Shamsabadi 3, Shahrbanoo Nakhaie 4, Maesoumeh Karimi Aghche 5, Mohammad Javad Azadchehr 6, Amin Sadat Sharif 7

What is “already known” in this topic
Zinc and vitamin D in sufficient concentrations help maintain the immune system's health. Therefore, their deficiency can cause various infections such as urinary tract infections (UTIs).
What this article adds:
Multiple factors potentially contribute to pediatric UTI development. This study examined associations between serum zinc and vitamin D as immune biomarkers and UTI while controlling for other known risk factors. This helps us determine whether optimizing levels of these immunesupportive micronutrients through diet and supplements could
lower UTI risk.

Background: Urinary tract infections (UTIs) are extremely prevalent bacterial infections among children. They have numerous potential causes. Without proper diagnosis and treatment, UTIs can lead to serious complications in children, including impaired growth, high blood pressure, protein in urine, and eventual chronic kidney disease. Zinc and vitamin D in sufficient concentrations help to maintain the health of the immune system. Therefore, their deficiency can cause various infections. Several factors can contribute to the development of UTIs. This article deals with the role of zinc and vitamin D as immune markers in UTI in children without other risk factors.

Methods: In this case-control study, serum zinc and vitamin D levels without any other risk factors were examined in 40 healthy children and 40 children with UTIs. Data analysis was done through SPSS 26 using the chi-square, the Fisher's exact, and independent t tests.

Results: The study findings demonstrated a statistically significant distinction between the 2 groups regarding serum vitamin D and zinc levels (P < 0.001); 80% of children with UTIs and 17.5% in the healthy group had vitamin D deficiency. Also, 60% of the urinary infection group had zinc deficiency, whereas 17.5% of the healthy group had it.

Conclusion: Low serum zinc and vitamin D levels may increase susceptibility to pediatric UTI. Given the data, supplementation with zinc and vitamin D could play a significant role in treating active infections and preventing recurrence in susceptible children.
 Download the PDF from Vitamin D Life

Vitamin D Life – Zinc and Vitamin D contains:

It appears that

• Low Zinc results in less vitamin D in blood getting to tissues
• Colds can be stopped by taking Zinc every 2-3 hours
  • COVID-19 risks appear to decrease by taking Zinc frequently
• Zinc improves the immune system and influences 300 enzymes
• Zinc deficiency has increased due to lack of Zinc in fertilizers as well as Roundup problems
• 20% of the people in the world do not get enough Zinc
• Zinc taste tests kind-of, sort-of work
• No agreement as to the best Zinc supplement
• Zinc loading doses appear to be safe
• Not much daily zinc is needed - 10 mg seems OK for most people,
     20 mg has been proven to cut in half the progression of prediabetes to diabetes
• FYI: Zinc is the oldest knows pill - used by the Romans WikiPedia

Half of young women get a URI annually - Perplexity AI Aug 2024

Urinary tract infections (UTIs) are a common health issue among women. Approximately 50-60% of women will experience at least one UTI in their lifetime. The frequency of UTIs can vary based on age and other factors.

Frequency of UTIs in Women

• Lifetime Incidence: Around 50-60% of women will have a UTI at some point in their lives.
• Annual Incidence: In young women, the estimated incidence of UTIs is about 0.5 episodes per person per year.
• Recurrent UTIs: About 25% of women experience recurrent UTIs, which are defined as having at least two infections in six months or three in a year.
• Age-Related Trends: The prevalence of UTIs increases with age. For example, in postmenopausal women, the rate is approximately double that of the overall female population.

Risk Factors
Several factors increase the likelihood of developing UTIs in women:

• Anatomy: Women are more prone to UTIs due to a shorter urethra, which allows bacteria easier access to the bladder.
• Sexual Activity: Increased sexual activity is a significant risk factor for UTIs, particularly in younger women.
• Postmenopausal Changes: Hormonal changes after menopause can increase UTI risk due to changes in the vaginal microbiome and bladder function.
• Other Health Conditions: Conditions like diabetes, use of catheters, and structural abnormalities in the urinary tract can also increase the risk.

Impact and Management
UTIs are responsible for a substantial number of medical visits annually and can significantly affect the quality of life due to symptoms like pain, frequent urination, and potential complications if left untreated. Management often involves antibiotics, but non-antimicrobial strategies, such as increased hydration and cranberry supplements, are also recommended to reduce recurrence.

Cranberry Juice cuts use of antibiotics for UTI in half - Aug 2024

MDEdge 8 studies