Vitamin D receptor (VDR) gene polymorphism influences the risk of osteoporosis in postmenopausal women of Northwest India.
Arch Osteoporos. 2013 Dec;8(1-2):147. doi: 10.1007/s11657-013-0147-y. Epub 2013 Aug 22.
Singh M, Singh P, Singh S, Juneja PK, Kaur T.
Molecular Genetics Laboratory, Department of Human Genetics, Punjabi University, Patiala, Punjab, India.
Abstract: The influence of VDR gene for the risk of osteoporosis has remained inconclusive.
VDR gene polymorphism in relation to BMD in postmenopausal women of Northwest India revealed a susceptibility haplotype AGT.
Possession of this haplotype exacerbates the risk of osteoporosis by 2.8 times, which manifests in recessive mode of inheritance.
PURPOSE:The purpose of this study is to understand the influence of coordinated effect of various single nucleotide polymorphisms (SNPs) within vitamin D receptor (VDR) gene for the risk of osteoporosis, which has remained undefined so far.
METHODS: Four pertinent SNPs of VDR gene, i.e., rs2228570, rs1544410, rs17879735, and rs731236 were examined with polymerase chain reaction-restriction fragment length polymorphism in dual energy X-ray absorptiometry verified 188 osteoporotics, 115 osteopenics, and 147 normal postmenopausal women of Northwest India.
RESULTS:Minor allele 'T' of rs2228570 showed significant influence for the risk of osteoporosis (OR 1.60, 95%CI 1.16-2.20, P = 0.004) and also in dominant (OR 2.32, 95%CI 1.47-3.64, P = 0.0006) and additive model (OR 2.41, 95%CI 1.49-3.87, P = 0.0006) after Bonferroni correction. Minor allele (T) of rs2228570 showed an allele dose effect with BMD of L1-L4 (P = 0.009) and FN (P = 0.036).
Disease association analysis exposed a susceptibility haplotype AGT which influences the risk of
- osteopenia (OR 2.04, 95%CI 1.03-4.08, P = 0.036) and
- osteoporosis (OR 2.90, 95%CI 1.61-5.38, P = 0.00005)
after adjusting the effects of age, BMI and years since menopause.
This haplotype is significantly associated with BMDs at lumbar spine (P = 0.0001) and femoral neck (P = 0.016).
CONCLUSION: In-depth analysis of this haplotype with other methods of Wald statistics and Akaike information criterion confirmed that carriers of each unit of this haplotype AGT increases the risk of osteoporosis by a factor of 2.80 ± 0.34 (β ± SE) which manifests (P = 0.1 × 10(-6)) in its recessive mode of inheritance.
PMID: 23975234
What to do about it?
With most vitamin D gene problems the simple remedy is to take more vitamin D so as to raise the vitamin D in the cell necessary to prevent/treat a disease. Sometimes this is raising the blood level, but not always.
Before gene typing it was noticed that some people did not get as much benefit from vitamin D as others. Genes are providing some insight as to why.
See also Vitamin D Life
- Overview Osteoporosis and vitamin D
- Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012
- 2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013
- Poorly functioning Vitamin D Receptor (VDR) was 5X more likely in children with low vitamin D levels – July 2012
Vitamin D Receptor category has the following
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
A poor VDR increases the risk of 55 health problems click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
Compensate for poor VDR by increasing one or more:
| Increasing | Increases |
| 1) Vitamin D supplement Sun, Ultraviolet -B | Vitamin D in the blood and thus in the cells |
| 2) Magnesium | Vitamin D in the blood AND in the cells |
| 3) Omega-3 | Vitamin D in the cells |
| 4) Resveratrol | Vitamin D Receptor |
| 5) Intense exercise | Vitamin D Receptor |
| 6) Get prescription for VDR activator paricalcitol, maxacalcitol? | Vitamin D Receptor |
| 7) Quercetin (flavonoid) | Vitamin D Receptor |
| 8) Zinc is in the VDR | Vitamin D Receptor |
| 9) Boron | Vitamin D Receptor ?, etc |
| 10) Essential oils e.g. ginger, curcumin | Vitamin D Receptor |
| 11) Progesterone | Vitamin D Receptor |
| 12) Infrequent high concentration Vitamin D Increases the concentration gradient | Vitamin D in the cells |
| 13) Sulfroaphone and perhaps sulfur | Vitamin D Receptor |
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR
Items in both categories Osteoporosis and Vitamin D Receptor are listed here:
- Osteoporosis Risk varies with Vitamin D Receptor – meta-analysis July 2020
- Prevent Osteoporosis and Have Strong Bones - book 2013
- Increased risk of Osteoporosis if poor Vitamin D Receptor (UK males this time) – Sept 2019
- Osteoporosis 3X higher risk of in white men having a poor Vitamin D receptor – Aug 2019
- Osteoporosis is associated with genes such as the Vitamin D Receptor – July 2019
- Osteoporosis 15 percent more likely if poor Vitamin D receptor – meta-analysis Dec 2018
- Disc Degeneration in women is 1.7X more likely if poor Vitamin D Receptor – meta-analysis Jan 2017
- Osteoporosis is associated with more than vitamin D genes – Jan 2016
- 2.8X higher risk of osteoporosis if COPD and modified vitamin D receptor genes – Sept 2015
- Osteoporosis 2.8 X more likely if Vitamin D receptor (VDR) genes altered – Aug 2013
- Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012
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