Vitamin D Attenuates Oxidative Damage and Inflammation in Retinal Pigment Epithelial Cells
Ali Mohammad Tohari 1,2, Reem Hasaballah Alhasani 2, Lincoln Biswas 2, Sarita Rani Patnaik 2, James Reilly 2, Zhihong Zeng 3,* and Xinhua Shu 2,4,
Vision category starts with the following
- Eye vitamin D may not be associated with blood VitD, but is associated with CYP27B1 and CYP24A1 – Nov 2019
- Vitamin D treats and prevents a variety of eye problems (need 70 ng) – June 2018
- Vitamin D and Myopia, AMD, Diabetic Retinopathy, Uveitis, Glaucoma, VDR etc. – May 2015
- Myopia may be related to low vitamin D
- Tears often have 25 % higher levels of vitamin D than does blood
- Cataracts prevented and perhaps treated by Vitamin D - 2015
- All people with Cataracts had low vitamin D levels – April 2019
- Vitamin D and Age-Related Macular Degeneration (and 2 AMD meta-analyses) – Oct 2017
- Vitamin D is the best vitamin to fight glaucoma – May 2018
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Age-related macular degeneration (AMD), the most common visual disorder in elderly people, is characterized by the formation of deposits beneath the retinal pigment epithelium (RPE) and by dysfunction of RPE and photoreceptor cells. The biologically active form of vitamin D, 1,25-(OH)2D3 (VITD), is categorized as a multifunctional steroid hormone that modulates many transcriptional processes of different genes and is involved in a broad range of cellular functions. Epidemiological and genetic association studies demonstrate that VITD may have a protective role in AMD, while single nucleotide polymorphisms in the vitamin D metabolism gene (CYP24A1) increase the risk of AMD. However, the functional mechanisms of VITD in AMD are not fully understood. In the current study, we investigated the impact of VITD on H2O2-induced oxidative stress and inflammation in human RPE cells. We demonstrate that exposure to H2O2 caused significantly reduced cell viability, increased production of reactive oxygen species (ROS), lowered expression of antioxidant enzymes and enhanced inflammation. VITD exposure notably counteracted the above H2O2-induced effects. Our data suggest that VITD protects the RPE from oxidative damage and elucidate molecular mechanisms of VITD deficiency in the development of AMD.
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