Nutrients 2022, 14(23), 4984; https://doi.org/10.3390/nu14234984
Matteo Tosato 1, Riccardo Calvani 1,*, Anna Picca 1,2, Francesca Ciciarello 1, Vincenzo Galluzzo 1, Hélio José Coelho-Júnior 1,3, Angela Di Giorgio 1, Clara Di Mario 4, Jacopo Gervasoni 1, Elisa Gremese 1,3,4, Paolo Maria Leone 1, Antonio Nesci 1, Anna Maria Paglionico 1, Angelo Santoliquido 1,5, Luca Santoro 1, Lavinia Santucci 6, Barbara Tolusso 4, Andrea Urbani 1,7, Federico Marini 8, Emanuele Marzetti 1,3 and Francesco Landi 1,3 on behalf of the Gemelli against COVID-19 Post-Acute Care Team
Distance traveled during 6 minute walk test
Long COVID, a condition characterized by symptom and/or sign persistence following an acute COVID-19 episode, is associated with reduced physical performance and endothelial dysfunction. Supplementation of l-arginine may improve endothelial and muscle function by stimulating nitric oxide synthesis. A single-blind randomized, placebo-controlled trial was conducted in adults aged between 20 and 60 years with persistent fatigue attending a post-acute COVID-19 outpatient clinic. Participants were randomized 1:1 to receive twice-daily orally either a combination of 1.66 g l-arginine plus 500 mg liposomal vitamin C or a placebo for 28 days. The primary outcome was the distance walked on the 6 min walk test. Secondary outcomes were handgrip strength, flow-mediated dilation, and fatigue persistence. Fifty participants were randomized to receive either l-arginine plus vitamin C or a placebo. Forty-six participants (median (interquartile range) age 51 (14), 30 [65%] women), 23 per group, received the intervention to which they were allocated and completed the study.
At 28 days, l-arginine plus vitamin C increased the 6 min walk distance (+30 (40.5) m; placebo: +0 (75) m, p = 0.001) and induced a greater improvement in handgrip strength (+3.4 (7.5) kg) compared with the placebo (+1 (6.6) kg, p = 0.03). The flow-mediated dilation was greater in the active group than in the placebo (14.3% (7.3) vs. 9.4% (5.8), p = 0.03).
At 28 days, fatigue was reported by two participants in the active group (8.7%) and 21 in the placebo group (80.1%; p <0.0001).
l-arginine plus vitamin C supplementation improved
(walking performance,
- muscle strength,
- endothelial function, and
- fatigue
in adults with long COVID. This supplement may, therefore, be considered to restore physical performance and relieve persistent symptoms in this patient population.
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60+ Vitamin D Life pages have LONG-HAUL or LONG-COVID in the title
Items found: 65
| Title | | Modified |
| Inflammation causes low iron, which triggers long-COVID – March 2024 | | 04 Apr, 2024 |
| Long-COVID 3.1 X more likely if insufficient amounts of Magnesium and Vitamin D – March 2024 | | 24 Mar, 2024 |
| Long-COVID a month shorter if more than 20 ng of Vitamin D - Jan 2024 | | 31 Jan, 2024 |
| Hypothesis: Both Long COVID and Vaccine Injury are caused by Spike Protein, proposed detox – Nov 2023 | | 24 Nov, 2023 |
| Long-COVID: Vitamin D was the only statistically significant factor - Oct 2023 | | 31 Oct, 2023 |
| Long COVID with Neuro-Cognitive symptoms had especially low vitamin D levels – Sept 2023 | | 19 Sep, 2023 |
| The ONLY Solution to Long COVID (Vitamin D) - video and transcript Sept 2023 | | 12 Sep, 2023 |
| Long-COVID can hide in the body for years in scores of locations – Sept 2023 | | 09 Sep, 2023 |
| One in five people with long COVID can no longer work (Doctors in this case) - Sept 2023 | | 02 Sep, 2023 |
| Number of people with long COVID could be vastly underestimated - Aug 2023 | | 01 Sep, 2023 |
| Long-COVID associated with 37 poor genes (no Vitamin D genes) – July 2023 | | 03 Aug, 2023 |
| COVID, Long-COVID and Vitamin D in children - Review April 2023 | | 09 Jul, 2023 |
| Fasting may reduce inflammation and long-COVID - June 2023 | | 11 Jun, 2023 |
| The US believes you have long-COVID if you have more than 12 points (no treatment yet) - May 2023 | | 25 May, 2023 |
| COVID, Long COVID, and Vitamin D – May 2023 | | 06 May, 2023 |
| 2nd COVID infection increases the risk of Long-COVID - 2022 | | 22 Jan, 2023 |
| Vitamin D might also help the Long-COVID older adult – Jan 2023 | | 07 Jan, 2023 |
| Long-COVID fatigue reduced by Vitamin C and l-Arginine in one month– RCT Nov 2022 | | 24 Nov, 2022 |
| Adrenal, Long-COVID and Vitamin D - several studies | | 31 Oct, 2022 |
| Long Covid, Short Magnesium - Chambers April 2022 | | 30 Oct, 2022 |
| Fatigue and other long-haul problems appear to be associated with low Magnesium - Chambers Oct 2022 | | 30 Oct, 2022 |
| Long-COVID symptoms in 10 Percent of women 3 months after infection (22 countries) – Oct 2022 | | 29 Oct, 2022 |
| Long-COVID is now the biggest COVID concern - many studies | | 16 Oct, 2022 |
| Epstein-Barr Virus probably causes Long-COVID, CFS, and MS - many studies | | 02 Oct, 2022 |
| Anti-oxidants and Long-Covid (Mg, Glutamate, Butyrate, etc) – Sept 2022 | | 02 Oct, 2022 |
| Chronic Fatigue Syndrome and long-haul COVID-19 | | 26 Sep, 2022 |
| Over Two Million Americans Aren’t Working Due to Long-COVID - Aug 2022 | | 27 Aug, 2022 |
| Long-COVID: often had not been hospitalized - May 2022 | | 25 Aug, 2022 |
| COVID virus persists in most body tissues (Long-COVID) - 2022 | | 23 Aug, 2022 |
| Long-COVID in Vitamin D Life | | 16 Aug, 2022 |
| LONG-COVID may be permanent in 1 in 200 of people infected – July 2022 | | 06 Aug, 2022 |
| Long-Haul more prevalent among seniors - June - 2022 | | 26 Jun, 2022 |
| Long-Haul can now be claimed a work disability in the UK – June 2022 | | 24 Jun, 2022 |
| Half as much Long-Haul with Omicron - June 2022 | | 19 Jun, 2022 |
| Half as much Long-Haul with Omicron - June 2022 | | 19 Jun, 2022 |
| COVID Spike persists in Long Haul - June 2022 | | 18 Jun, 2022 |
| COVID Long-Haul prevalence increases with time: 50% at 4 months - meta June 2022 | | 17 Jun, 2022 |
| COVID and Magnesium - hypothesis, clinical trials, Long-Haul - Oct 2021 | | 10 Jun, 2022 |
| Mass disabling events: Polio, WWII, HIV, and COVID Long-Haul - June 2022 | | 06 Jun, 2022 |
| 1 in 5 Americans who got COVID had Long-Haul for a while - CDC May 2022 | | 27 May, 2022 |
| Long-Haul COVID after 3 months – only 5 percent had even 30 ng of Vitamin D – April 2022 | | 04 May, 2022 |
| Hypothesis: 2 long-haul COVIDs: had mild symptoms and had needed ICU - April 2022 | | 15 Apr, 2022 |
| COVID Long-Haul at 49 weeks: overactive immune system, type O blood - March 2022 | | 07 Apr, 2022 |
| Children have less severe COVID, but just as much long-haul as adults - April 2022 | | 06 Apr, 2022 |
| Dietary Recommendations for COVID Long-Haul – March 2022 | | 20 Mar, 2022 |
| Mild Long-Haul 4.2 X more likely if type O blood - preprint March 16, 2022 | | 20 Mar, 2022 |
| Long-Haul COVID is somewhat less of a problem if vaccinated – Nov 2021 | | 18 Mar, 2022 |
| COVID long-haul: 1 million in US too sick to work, many cannot get compensation - March 2021 | | 09 Mar, 2022 |
| COVID Long-Haul NYT - Feb 2022 | | 19 Feb, 2022 |
| COVID Long-Haul fought by probiotics - Jan 2022 | | 29 Jan, 2022 |
| COVID Long-Haul predicted by 4 factors (Epstein-Barr virus, etc) – Jan 24, 2022 | | 26 Jan, 2022 |
| Some COVID-19 infection become COVID Long-Haul - Nov 2020 | | 15 Dec, 2021 |
| Long-haul after breakthrough COVID – Nov 2021 | | 11 Dec, 2021 |
| Long-haul, VAERS, Ivermectin, vaccines, etc. Drs. Seheult, Patrick: Video with table of contents - Sept 17, 2021 | | 21 Sep, 2021 |
| Your Brain on Covid-19 Long-Haul, Dr. Galland video and transcript - Aug 1, 2021 | | 07 Aug, 2021 |
| Long-haul COVID-19 blood tests at Mayo include vitamin D (but no results published) – July 2021 | | 20 Jul, 2021 |
| Most people with Long-Haul COVID-19 have low Vitamin D – July 2021 | | 15 Jul, 2021 |
| ‘Long haul’ COVID rehab worse than cancer rehab, CDC – July 2021 | | 13 Jul, 2021 |
| Long-Haul COVID-19 occurred to 1 in 20 who had been asymptomatic (a study of 2 million with COVID-19) – June 2021 | | 15 Jun, 2021 |
| COVID-19 Long haul - excellent graph - systematic review May 26, 2021 | | 26 May, 2021 |
| COVID-19 vaccines look good in the short term, but probably not good for the long term | | 29 Apr, 2021 |
| Long-haul COVID-19 - another hint that Vitamin D should help - Dec 2020 | | 16 Apr, 2021 |
| Probably fewer long-haul COVID-19 problems when rejuvenated immune system (Vitamin D, etc.)– Dec 2020 | | 21 Feb, 2021 |
| Long-haul fatigue, etc. common after viral infections (SARS1,2, MERS, Swine, 1918,...) | | 21 Feb, 2021 |
| Long-distance truck drivers more likely to get COVID-19 (perhaps UVA)- July 2020 | | 12 Aug, 2020 |
L-arginine allow production of Nitric Oxide (also produced in the skin by sunlight) Life Extension
- "In healthy adults, L-arginine is a nonessential amino acid, which means that your body is able to produce some of it on its own"