Loading...
 
Toggle Health Problems and D

Less bad gut bacteria in infant if even tiny amount of vitamin D during pregnancy – Nov 2017

Influence of vitamin D on key bacterial taxa in infant microbiota in the KOALA Birth Cohort Study

PLOS X: November 9, 2017https://doi.org/10.1371/journal.pone.0188011
Chris E. Talsness, John Penders, Eugène H. J. M. Jansen, Jan Damoiseaux, Carel Thijs, Monique Mommers

Vitamin D has immunomodulatory properties giving it the potential to affect microbial colonization of the intestinal tract. We investigated whether maternal vitamin D supplemention, maternal plasma 25-hydroxyvitamin D concentration, or direct supplementation of the infant influences key bacterial taxa within microbiota of one month old infants. Infant and maternal vitamin D supplement use was ascertained via questionnaires. Maternal plasma 25-hydroxyvitamin D was determined at approximately the 36th week of pregnancy.
In 913 one month old infants in the prospective KOALA Birth Cohort Study, fecal

  • Bifidobacterium spp.,
  • Escherichia coli,
  • Clostridium difficile,
  • Bacteroides fragilis group,
  • Lactobacillus spp. and
  • total bacteria

were quantified with real-time polymerase chain reaction assays targeting 16S rRNA gene sequences. The association between vitamin D exposure and prevalence or abundance of a specific bacterial group or species was analyzed using logistic or linear regression, respectively. There was a statistically significant negative linear trend between counts of Bifidobacterium spp. and levels of maternal vitamin D supplementation and maternal 25-hydroxyvitamin D quintiles, respectively. In addition, a positive linear trend between quintile groups and B. fragilis group counts was observed. Lower counts of C. difficile were associated with vitamin D supplementation of breast fed infants whose mothers were more likely to adhere to an alternative lifestyle in terms of, e.g., dietary habits. These data suggest that vitamin D influences the abundance of several key bacterial taxa within the infant microbiota. Given that intestinal microbiotic homeostasis may be an important factor in the prevention of immune mediated diseases and that vitamin D status is a modifiable factor, further investigation of the impact of postnatal vitamin D supplementation should be conducted in older infants.

 Download the PDF from Vitamin D Life


Created by admin. Last Modification: Thursday November 9, 2017 23:52:53 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
8682 Infant bacteria.pdf admin 09 Nov, 2017 1.03 Mb 558