Vitamin D Deficiency in Egyptian Systemic Lupus Erythematosus Patients: How Prevalent and Does It Impact Disease Activity?
Integrative Medicine Insights 2016:11 27-33 doi: 10.4137/IMI.S40035
Nouran M. Abaza1, Reem M. El-Mallah1, Asmaa Shaaban1, Sameh A. Mobasher2, Khaled F. Al-hassanein2, Amr A. Abdel Zaher2 and Rania H. El-kabarity3
1Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Ain Shams University, Cairo, Egypt. internal Medicine - Rheumatology Division, Faculty of Medicine, Ain Shams University, Cairo, Egypt. 3Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
| Vitamin D level | |
| SLE | 18 ng |
| Controls | 79 ng |
Controls had 4 X higher Vitamin D level - a level which seems very high
See also Vitamin D Life
The TOP articles in Lupus and Vitamin D are listed here:
- Lupus is both prevented and treated by Vitamin D – review Dec 2017
- Autoimmune diseases associated with low Vitamin D and Vitamin D Receptor – July 2017
- If Lupus in family – 5 times more likely to get Lupus if low vitamin D and poor CYP24A1 – June 2016
- Lupus – vitamin D is essential in preventing and modulating it – May 2016
- Juvenile Lupus fatigue reduced by vitamin D ( 50,000 IU weekly for 6 months) – RCT May 2015
- Lupus flareups cut in half by just 2,000 IU of vitamin D – RCT Dec 2012
The TOP articles in Autoimmune and Vitamin D are listed here:
- Breastfeeding a child without adding vitamin D increases risk of many food allergies (egg whites in this case) – Jan 2020
- Resveratrol treats Multiple Sclerosis and other autoimmune diseases – many studies
- Multiple Sclerosis – 3X higher incidence in women, previously 1X, wonder why
- Vitamin D is the real Multiple Sclerosis Therapy, not an alternative therapy – Coimbra July 2018
- Stress increased the risk of getting multiple autoimmune diseases by 2.3 X – June 2018
- Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018
- Autoimmune diseases associated with low Vitamin D and Vitamin D Receptor – July 2017
- Multiple Sclerosis and Vitamin D ~ 50,000 Facebook members in 13 languages – Jan 2017
- Interview of Dr. Coimbra - Vitamin D protocol for Autoimmune diseases – 2016
- Autoimmune disease clusters run in families (polyautoimmunity) are associated with low vitamin D
- Many autoimmune diseases associated with latitude and vitamin D receptor – March 2016
- 1000 IU per kg Vitamin D for autoimmune diseases – Coimbra Aug 2013
- Video by Dr. Coimbra – 95 percent of auto-immune cured with vitamin D in high doses - April 2014
- Chronic Hives treated by Vitamin D - many studies
- Myasthenia gravis score improved 38 percent with just 800 IU of vitamin D daily – Dec 2012
- Vitamin D protects against many types of health problems – review May 2013
- Autoimmune disorder patients in Brazil helped by vitamin D – video and Facebook – Nov 2012
Book: Vitamin D and Autoimmune Disease: How Vitamin D Prevents Autoimmune Disease
$5, Amazon Oct 2014, author discovered the solution for himself.
Download the PDF from Vitamin D Life
BACKGROUND: The emerging role of vitamin D in immunology and autoimmune disorders has been a worldwide interest in the last decade. Systemic lupus erythematosus (SLE) patients are particularly at a delicate position predisposing them to suffer from vitamin D deficiency due to the multiple risk factors accompanying the disease. Whether vitamin D deficiency is also involved as a risk factor for developing SLE and affecting its course is a considerable concern.
OBJECTIVES: The objective of this study was to estimate the prevalence of vitamin D deficiency in SLE patients and its relation to disease.
MATERIALS AND METHODS: In our observational cross-sectional study, serum levels of vitamin D [25(OH)D] in 60 SLE patients and 30 age- and sex-matched healthy controls were assessed and estimated for deficiency and insufficiency at 10 and 30 ng/mL, respectively. Disease activity was evaluated by SLE disease activity index (SLEDAI), irreversible organ damage by Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SLICC/ACR DI), and severity by Severity of Disease Index. Fatigue was measured by visual analog scale.
RESULTS: Significantly lower levels of 25(OH)D were found in SLE patients (17.6 ± 6.9 ng/mL) in comparison to controls (79.0 ± 28.7 ng/mL), with a statistically high significant difference (t = -11.2, P < 0.001). High prevalence of vitamin D insufficiency and deficiency was detected as 73.3% and 23.3%, respectively. Vitamin D had a highly significant negative correlation with SLEDAI (r = -0.495, P < 0.001), SLICC (r = -0.431, P < 0.05), and fatigue (r = -0.436, P < 0.05).
CONCLUSION: Vitamin D deficiency and insufficiency were found to be prevalent in SLE patients in our study and related to disease activity and fatigue. If needed, routine screening and consequent repletion of vitamin D are recommended in SLE patients. Restoring adequate vitamin D levels in SLE patients should be more explored as a potential yet simple measure to their usual management to improve their condition.
Snipped from PDF
- “Twenty patients (33.3%) had CNS affection in the form of headache, cognitive dysfunction, and peripheral neuritis,
another 34 patients (56.7%) had joint affection in the form of arthralgia or arthritis.” - “Fatigue was found to be prevalent in 97.7% of our studied SLE patients”
- Patients with autoimmune diseases such as multiple sclerosis, RA, and SLE show low 25-OH vitamin D serum levels. Some studies suggested that adequate vitamin D levels diminished the risk for developing various autoimmune diseases.3,40,41”
- “So, it is time to routinely give vitamin D supplementation to SLE patients after periodic measurement of its level.”
| 1982 visitors, last modified 08 Feb, 2018, |