Loading...
 
Toggle Health Problems and D

Inflammation associated with Cancer reduced by Vitamin D – meta-analysis May 2023

Effects of vitamin D supplementation on inflammatory response in patients with cancer and precancerous lesions: Systematic review and meta-analysis of randomized trials

Clin Nutr. 2023 May 17;S0261-5614(23)00151-6. doi: 10.1016/j.clnu.2023.05.009
Tafirenyika Gwenzi 1, Anna Zhu 2, Petra Schrotz-King 3, Ben Schöttker 4, Michael Hoffmeister 5, Hermann Brenner 6

Background & aims: Inflammation plays a key role in tumor development and progression. Vitamin D has potential tumor suppressing effects through modulation of inflammatory processes. The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) was to summarize and evaluate the effects of vitamin D3 supplementation (VID3S) on serum inflammatory biomarkers among patients with cancer or pre-cancerous lesions.

Methods: We searched PubMed, Web of Science and Cochrane databases until November 2022. The effects of VID3S were estimated from pooled standardized mean differences (SMDs) with their 95% confidence intervals (CIs) for inflammatory biomarker follow-up levels between intervention and control groups.

Results: Meta-analysis of eight RCTs (total of 592 patients with cancer or pre-cancerous conditions) showed that VID3S significantly lowered levels of serum tumor necrosis factor (TNF)-α (SMD [95%CI]: -1.65 [-3.07; -0.24]). VID3S also resulted in statistically non-significantly lower serum levels of interleukin (IL)-6 (SMD [95%CI]: -0.83, [-1.78; 0.13]) and C-reactive protein (CRP) (SMD [95%CI]: -0.09, [-0.35; 0.16]), whereas IL-10 levels were unaltered (SMD [95%CI]: -0.00, [-0.50; 0.49]).

Conclusion: Our study shows evidence of a significant reduction of TNF-α levels by VID3S for patients with cancer or precancerous lesions. Patients with cancer or precancerous lesions may benefit from personalized VID3S in suppressing tumour-promoting inflammatory response.

Prospero registration number: CRD42022295694.
No such attachment on this page

Note: Many of the trials used too little vitamin D to be of any possible benefit

4+ Vitamin D Life Inflammation pages with CANCER in the title

This list is automatically updated

Items found: 4

Vitamin D Life – Cancer category contains

Vitamin D Life – Cancer increases if poor Vitamin D Receptor (not mentioned in study on this page)

Cancers get less Vitamin D when there is a poor Vitamin D Receptor

39+ Vitamin D Life Mortality pages have CANCER in the title

This list is automatically updated

Items found: 40
Title Modified
US Cancer statistics - Jan 2025 19 Feb, 2025
Pancreatic cancer mortality 28% more likely if low vitamin D – meta-analysis Jan 2024 28 Nov, 2024
3 Cancers have higher mortality if high PTH (which can be lowered by Vitamin D) - Aug 2024 15 Aug, 2024
Fewer deaths (All-cause, Cardiovascular, Cancer) when Vitamin D levels are above 36 ng – April 2024 01 May, 2024
People with Cancer having more than 30 ng of Vitamin D are 40% less likely to die (of any cause) – Nov 2023 23 Nov, 2023
Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013 31 Jul, 2023
Cancer incidence or mortality not changed by small Vitamin D doses: 2021-2023 01 May, 2023
Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018 30 Apr, 2023
Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022 03 Jul, 2022
Cancer incidence and death reduced by both Vitamin D and UVB – Grant Oct 2021 15 Oct, 2021
Cancer mortality not reduced by small vitamin D doses - Sept 2021 21 Sep, 2021
Cancer death (non-skin) 2.3 X more likely if low Vitamin D – Aug 2021 17 Aug, 2021
Deaths after Cancer Surgery higher in blacks (probably low vitamin D) – Dec 2020 10 Jan, 2021
Cancer patients in ICU with low vitamin D were 3.4 X more likely to die within a year – Dec 2020 31 Dec, 2020
Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020 09 Nov, 2020
Cancer is leading cause of death - Vitamin D and Receptor activators help 09 Nov, 2019
Mortality increased: 4X Cancer, 5X Diabetes if eat a lot of meat protein – March 2014 08 Nov, 2019
Vitamin D Supplements Reduce Cancer Mortality – Greger Sept 2019 10 Sep, 2019
Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019 05 Jul, 2019
People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019 05 Jul, 2019
Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019 07 May, 2019
Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019 13 Apr, 2019
Cancer patients 64% less likely to die if have high level of vitamin D – Dec 2011 26 Nov, 2018
Vitamin D reduces the risk of Breast Cancer, improves treatment, and improves survival 10 Sep, 2018
The “Deadly Breast Cancer Gene” Is A Myth, Lancet Study Confirms – Jan 2018 13 Jan, 2018
Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017 29 Dec, 2017
Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017 13 Jun, 2017
Death after Breast Cancer 2 times less likely if take lots of Magnesium – Dec 2015 15 Jun, 2016
Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013 09 Nov, 2014
Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014 30 Sep, 2014
Cancer incidence not reduced by 1100 IU of vitamin D (proven again) but mortality decreased – June 2014 17 Jun, 2014
Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 12 May, 2014
More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014 08 May, 2014
Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014 08 Apr, 2014
Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013 06 Mar, 2014
Vitamin D and Cancer Mortality – review Jan 2013 17 Sep, 2013
Mortality and Cancer varies with latitude in France too – 2010 26 Oct, 2012
More US deaths due to cancer than heart if dark skinned – Sept 2012 18 Sep, 2012
Lack of solar UVB in US is associated with some Cancers - 2006 28 Dec, 2011
Solar radiation, vitamin D and cancer incidence and mortality in Norway 13 Apr, 2010

20 Most-visited pages in Cancer (general) category

 Id Page Hits Last modification Creator Categories
12600 Cancer during childhood - many studies 259686
29 Apr, 2025 21:32
 admin Cancer
Infant-Child
14802 Much more likely to survive cancer if more than 20 ng of Vitamin D - Oct 2023 234260
31 Oct, 2023 20:58
 admin Cancer
14713 Multiple COVID vaccinations might increase (turbo) Cancer Incidence - many studies 224284
05 Sep, 2025 16:49
 admin Cancer
Virus
931 Overview Cancer and vitamin D 155923
02 Aug, 2025 20:04
 admin Cancer
Overviews
14988 Childhood Cancers - Vitamin D can help - many studies 125067
20 Jan, 2024 18:44
 admin Cancer
Infant-Child
15180 Magnesium and Cancer - many studies 122177
12 Mar, 2025 22:32
 admin Cancer
Vitamin D and Magnesium
7430 Cancer risk reduced 65 percent by vitamin D levels greater than 40 nanograms – April 2016 103819
31 Dec, 2022 19:58
 admin Cancer - Breast
Cancer
Intervention
Top news
3389 Cancer 73383
10 Jan, 2025 23:57
 ricks99 Cancer
Category
62 Vitamin D decreases incidence of disease 53588
01 Jan, 2025 01:55
 admin How much Vitamin D
Cardiovascular
Kidney
Diabetes
Multiple Sclerosis
Rickets
Health
About D - introduction
Cancer
5796 Obesity increases Cancer - perhaps due to low vitamin D - many articles 38875
13 Nov, 2023 16:36
 admin Obesity
Cancer
12334 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D 37854
02 Feb, 2024 13:29
 admin Skin - Dark
Deficiency of Vitamin D
Cardiovascular
Kidney
Diabetes
Obesity
Cancer
Cystic Fibrosis
High Risk
Top news
Hypertension
Virus
4983 Vitamin D Receptor role in Autoimmune Diseases and or cancers – Nov 2013 30836
04 Oct, 2021 13:19
 admin Autoimmune
Cancer
Vitamin D Receptor
847 How I Treat Vitamin D Deficiency - for Cancer Mar 2010 29845
17 Mar, 2012 10:42
 admin Deficiency of Vitamin D
Cancer
Cancer - after diagnosis
Overview for doctors
Treatment by Vitamin D
5322 Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 28026
06 Aug, 2024 17:17
 admin Mortality and D
Cancer - Colon
Cancer - Breast
Cancer
Meta-analysis of Vitamin D
Cancer - Lymphoma
3842 Vitamin D increasingly associated with inflammation such as RA, TB, Lupus, and cancer – March 2013 27484
13 Jul, 2013 18:41
 admin Tuberculosis
Lupus
Rheumatoid Arthritis
Cancer
Inflammation
10627 Cancer stem cells and Vitamin D - many studies 26846
30 Oct, 2022 13:12
 admin Health
Cancer
Top news
6595 Obesity causes 20 percent of all cancer, low vitamin D may be the connection – meta-analysis - Sept 2014 24941
26 Jun, 2021 12:25
 admin Obesity
Cancer
Meta-analysis of Vitamin D
2248 Possible ways that vitamin D does its magic 22780
03 Jun, 2014 20:45
 admin More D topics
Cancer
Genetics
9707 Embrace the Sun – benefits of the sun (Nitric Oxide etc.) – book June 2018 22641
05 Aug, 2024 09:40
 admin Noontime sun and D
UV and Vitamin D
Books, videos on Vitamin D
Cancer
Top news
3910 Low vitamin D strongly related to death due to tobacco cancer, but not others – March 2013 22202
24 Jan, 2015 17:42
 admin Cancer
Cancer - Lung

89+ Cancer Meta-analyses in Vitamin D Life

This list is automatically updated

Items found: 89
Title Modified
Non-cancer colon growths 7 % less likely per 10 ng increase in Vitamin D – Oct 2011 08 Dec, 2024
Graphs of Vitamin D and Cancer – meta-analysis Dec 2011 08 Dec, 2024
Pancreatic cancer mortality 28% more likely if low vitamin D – meta-analysis Jan 2024 28 Nov, 2024
Analysis of 280 Breast Cancer meta-analyses: having low vitamin D was highly suggestive – umbrella July 2024 28 Jul, 2024
Bladder cancer in muscles 2.7 times more-likely if vitamin D less than 20 ng -meta-analysis May 2024 23 May, 2024
1.5X more likely to die of Prostate Cancer if low vitamin D when initially diagnosed – meta-analysis March 2024 13 Mar, 2024
Pancreatic Cancer survival 2.3 X more likely if good level of Vitamin D – meta-analysis Sept 2023 15 Sep, 2023
Thyroid Cancer 1.4 X higher risk if low vitamin D– meta-analysis Feb 2018 29 Aug, 2023
Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013 31 Jul, 2023
16 factors increase the risk of early-onset colorectal cancer, only vitamin D decreases the risk – meta-analysis May 2023 22 May, 2023
Melanoma is 1.4X more-likely if low Vitamin D – meta-analysis May 2023 18 May, 2023
Breast Cancer not prevented by vitamin D when use small doses or for just a short time – Meta-analysis April 2023 11 May, 2023
Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018 30 Apr, 2023
Breast Cancer risk - meta-analysis of 50 studies - Dec 2019 25 Mar, 2023
Ovarian Cancer 37 percent less likely if high vitamin D – meta-analysis March 2023 20 Mar, 2023
Colorectal Cancer 10 percent more likely if poor Vitamin D Receptor – meta-analysis Jan 2023 08 Jan, 2023
Melanoma might be suppressed by Vitamin D - many studies 25 Nov, 2022
Colorectal cancer 14 percent less likely if 10 ng more Vitamin D – 22nd meta-analysis – Sept 2022 13 Sep, 2022
USPSTF says no evidence that Vitamins prevent CVD or Cancer (data disagrees) Aug 2022 05 Sep, 2022
Even after a Cancer diagnosis Vitamin D improves survival – meta-analysis Aug 2022 19 Aug, 2022
Colorectal cancer 40 percent less likely if 1000 IU more Vitamin D – 21st meta-analysis – Oct 2021 29 Oct, 2021
Colorectal cancer 25 percent less likely if good level of Vitamin D – 20th meta-analysis – June 2021 02 Jul, 2021
Lung Cancer death 40 percent less likely if high level of Vitamin D – meta-analysis Nov 2020 24 Nov, 2020
Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020 09 Nov, 2020
Vitamin D fights 13 cancers – review of 35 meta-analyses – Oct 2020 06 Oct, 2020
Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020 02 Oct, 2020
Colorectal cancer treated by Vitamin D – 19th meta-analysis – Sept 2020 17 Sep, 2020
3X less risk of Liver cancer if more than 30 ng of vitamin D – meta-analysis July 2020 28 Jul, 2020
Liver Cancer 8 percent less likely for every 4 ng higher level of vitamin D – Meta-analysis April 2020 02 Apr, 2020
Melanoma 2.1 X more likely if low vitamin D – meta-analysis Jan 2020 11 Jan, 2020
Breast Cancer risk reduced 17 percent by 1 hour of daily summer sun – meta-analysis Jan 2020 07 Jan, 2020
Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019 14 Dec, 2019
Colon cancer both prevented and treated by Vitamin D – meta-analysis Dec 2019 04 Dec, 2019
Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016 09 Nov, 2019
Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019 05 Jul, 2019
People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019 05 Jul, 2019
Breast Cancer rate reduced by 40 percent with Omega-3 – meta-analysis June 2013 16 Jun, 2019
Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis June 2019 13 Jun, 2019
Variety of Vitamin D forms treat Prostate Cancer – RCT Review April 2019 01 May, 2019
Pancreatic cancer risk of death reduced 19 percent by Vitamin D – meta-analysis June 2017 20 Mar, 2019
Breast Cancer reduced 20 percent by fish (Omega-3) – meta-analysis Feb 2019 05 Mar, 2019
16 percent less Prostate Cancer sometimes for each 10 ng vitamin D increase - meta-analysis Jan 2011 13 Oct, 2018
Lung Cancer risk decreased 2.4 percent with every 100 IU Vitamin D extra intake – meta-analysis Sept 2018 15 Sep, 2018
Colorectal cancer is associated with Vitamin D (17 meta-analyses so far) – July 2018 18 Jul, 2018
Thyroid Cancer 1.3X higher risk if low vitamin D (yet again) – meta-analysis June 2018 02 Jun, 2018
Cancer not treated by Vitamin D when ignore dose size, type, and length of trial – meta-analysis April 2018 09 Apr, 2018
Pancreatic cancer risk reduced 25 percent by just 10 micrograms of Vitamin D or Vitamin B12 – meta-analysis March 2018 30 Mar, 2018
Prostate cancer risk increase with Vitamin D (other studies disagree) – meta-analysis Jan 2018 11 Jan, 2018
Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017 29 Dec, 2017
Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017 14 Dec, 2017
Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene – July 2017 27 Jul, 2017
Lymphoma, leukemia etc, survival poor if low vitamin D – meta-analysis March 2015 06 Jul, 2017
Lung Cancer less likely if vitamin D (higher level or supplement) – meta-analysis May 2015 06 Jul, 2017
Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017 13 Jun, 2017
Lung Cancer risk decreases 5 percent for every 2.5 nanogram increase in Vitamin D – meta-analysis Sept 2015 22 Feb, 2017
Colorectal cancer 60 percent less likely: high vs low Vitamin D level – meta-analysis Dec 2016 22 Dec, 2016
Colorectal Cancer recurrence not prevented by 1,000 IU of vitamin D – meta-analysis Dec 2016 09 Dec, 2016
Bladder cancer modifiable risk factors include low vitamin D – meta-analysis March 2016 08 Dec, 2016
Bladder cancer 60 percent less likely if have high vitamin D – meta-analysis Dec 2015 08 Dec, 2016
Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014 12 Nov, 2016
10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012 23 Sep, 2016
Kidney cancer 22 percent less likely if high vitamin D – meta-analysis Nov 2015 30 Mar, 2016
Bladder cancer 25 percent less likely if have high vitamin D – meta-analysis April 2015 24 Dec, 2015
Bladder cancer 25 percent less likely if have high vitamin D – meta-analysis Oct 2014 24 Dec, 2015
Cancer risk weakly associated with vitamin D-binding protein – meta-analysis Sept 2015 15 Oct, 2015
Colon cancer 30 percent more likely if low vitamin D – 12th meta-analysis Aug 2015 14 Aug, 2015
Obesity causes 20 percent of all cancer, low vitamin D may be the connection – meta-analysis - Sept 2014 31 May, 2015
Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015 03 May, 2015
Colon cancer risk reduced by many vitamins – 13 percent reduction by Vitamin D – meta-analysis Jan 2015 11 Dec, 2014
Breast Cancer – review of 2 RCT did not find association with 1000 IU of Vitamin D – July 2013 16 Nov, 2014
Cancer (colon, breast, lymph) survival about 2X better with high level vitamin D – meta-analysis July 2014 30 Sep, 2014
Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014 30 Sep, 2014
Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 12 May, 2014
More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014 08 May, 2014
Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014 08 Apr, 2014
Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013 06 Mar, 2014
Breast Cancer post menopause down 12 percent for every 5 ng of vitamin D – meta-analysis May 2013 28 Oct, 2013
Probably need more than 1000 IU of vitamin D to prevent cancer – meta-analysis Aug 2013 20 Aug, 2013
3.2 percent less Breast Cancer for 2.4 ng more vitamin D – meta-analysis June 2013 08 Jul, 2013
Colorectal cancer 26 percent less likely for every 10 ng of vitamin D – meta-analysis Aug 2011 10 Nov, 2012
Breast cancer association with low vitamin D suggested by Meta-analysis -April 2010 19 Jul, 2012
Colon cancer probability increases with decreased vitamin D – Meta-analysis July 2011 23 Jun, 2012
Vitamin D has a complex relationship with Cancer – meta-analysis July 2011 30 Sep, 2011
Meta-analysis of 3 cancers - 10 ng more vitamin D decrease colorectal by 15 percent– May 2010 31 Aug, 2011
Risk of Prostate Cancer weakly associated with vitamin D - meta-analysis March 2011 11 Aug, 2011
Meta-analysis found vitamin D association with colon but not prostate nor breast cancer May 2010 17 Jan, 2011
Meta-analysis not find low vitamin D years before breast cancer – Aug 2010 10 Sep, 2010
Meta-analysis confirmed that vitamin D and calcium prevents breast cancer – June 2010 30 Aug, 2010
Meta-analysis did not find strong association between vitamin D and breast cancer risk -April 2010 12 May, 2010

See also web

  • Phrases associated with cancer NYT Jan 2015
    “failed tamoxifen”,“platinum resistant” or “refractory” patient, “relapsed” scans which are “clean,” “positive” or “advancing” spells trouble
    nodes have been “harvested”; a tumor is “indolent, “minimal or acceptable side effects,” scanxiety,
    Nothing about vitamin D
  • How cancer cells form tumors by reaching out with ‘cables’ and grabbing cells Jan 2016 (nothing about vitamin D)
    "Surprisingly, as little as five percent of cancerous cells are needed to form the tumors, a ratio previously unknown."
    “It’s that these cells go out and actively recruit. It’s complicated stuff, and it’s not passive. No one had a clue that there were specialized cells in this process, and that it’s a small number that pulls all the rest in.”
    Images from the movie

Image

Inflammation associated with Cancer reduced by Vitamin D – meta-analysis May 2023        
3863 visitors, last modified 28 May, 2023,
Printer Friendly Follow this page for updates
Cancer 280 Inflammation 171
Page actions
Print
Edit Files 1

Attached files

ID Name Comment Uploaded Size Downloads
19607 precancerous lesions meta_CompressPdf.pdf admin 28 May, 2023 599.81 Kb 115