Higher Vitamin D-binding protein is good (neonates in this case) – Feb 2023

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Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots

.Nat Commun 2023 Feb 15;14(1):852. doi: 10.1038/s41467-023-36392-5.

Clara Albiñana 1, Zhihong Zhu 1, Nis Borbye-Lorenzen 2, Sanne Grundvad Boelt 2 3, Arieh S Cohen 4, Kristin Skogstrand 2, Naomi R Wray 5 6, Joana A Revez 5, Florian Privé 1, Liselotte V Petersen 1 7, Cynthia M Bulik 8 9 10, Oleguer Plana-Ripoll 1 11, Katherine L Musliner 12, Esben Agerbo 1 7 13, Anders D Børglum 7 14 15, David M Hougaard 7 16, Merete Nordentoft 7 17 18, Thomas Werge 7 19 20 21, Preben Bo Mortensen 1 7 13, Bjarni J Vilhjálmsson 1 7 22, John J McGrath 23 24 25

The Vitamin D binding protein (DBP), encoded by the group-specific component (GC) gene, is a component of the Vitamin D_system. In a genome-wide association study of DBP concentration in 65,589 neonates we identify 26 independent loci, 17 of which are in or close to the GC gene, with fine-mapping identifying 2 missense variants on chromosomes 12 and 17 (within SH2B3 and GSDMA, respectively). When adjusted for GC haplotypes, we find 15 independent loci distributed over 10 chromosomes. Mendelian randomization analyses identify a unidirectional effect of higher DBP concentration and (a) higher 25-hydroxyvitamin D concentration, and (b) a reduced risk of multiple sclerosis and rheumatoid arthritis. A phenome-wide association study confirms that higher DBP concentration is associated with a reduced risk of Vitamin D deficiency. Our findings provide valuable insights into the influence of DBP on Vitamin D status and a range of health outcomes.
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Grant support
na/Danmarks Grundforskningsfond (Danish National Research Foundation)
R345-2020-1588/Lundbeckfonden (Lundbeck Foundation)
R102-A9118, R155-2014-1724, and R248-2017-2003/Lundbeckfonden (Lundbeck Foundation)
R276-2018-4581/Lundbeckfonden (Lundbeck Foundation)
R335-2019-2339/Lundbeckfonden (Lundbeck Foundation)

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Vitamin D Life – Vitamin D Binding Protein category listing has 176 items and the following introduction

Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,

• GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
• The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
• The actual D getting to the cells is a function of measured D and all 4 genes
• There is >2X increase in 8+ health problems if have poor VDBP (GC)
• It appears that VDBP only blocks oral vitamin D,
  • but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
  • A clue: - Vitamin D from UV is 2X better for MS than oral Vitamin D

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Vitamin D Life – Vitamin D Binding Protein has a list of health problems

Increased Risk	Health Problem
11 X	Preeclampsia
6.5X	T1D in SA Blacks
6 X	Food Allergy
5 X	PTSD
4 X, 5X	Kidney Cancer
4 X	Poor Response to Oral Vitamin D
3 X	Ear infection
2.8 X	MS
2 X	Colorectal Cancer
2 X	Prostate Cancer -in those with dark skins
1.3 X	Infertility

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Vitamin D Life - Genetics chart shows the vitamin D genes

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