Low vitamin d status is associated with nonalcoholic Fatty liver disease independent of visceral obesity in korean adults.
PLoS One. 2013 Oct 9;8(10):e75197. doi: 10.1371/journal.pone.0075197.
Seo JA, Eun CR, Cho H, Lee SK, Yoo HJ, Kim SG, Choi KM, Baik SH, Choi DS, Yim HJ, Shin C, Kim NH.
Division of Endocrinology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
OBJECTIVE: To investigate the association between serum 25-hydroxyvitamin D [25(OH)D] levels and nonalcoholic fatty liver disease (NAFLD) independent of visceral obesity in Koreans and to examine whether the associations differ according to the presence of diabetes or insulin resistance.
RESEARCH DESIGN AND METHODS: A total of 1081 adults were enrolled from a population-based cohort in Ansan city. Serum 25(OH)D concentrations were measured in all subjects. Insulin resistance was measured by homeostasis model assessment of insulin resistance (HOMA-IR). Using computed tomography, NAFLD was diagnosed if the liver attenuation index (LAI, the difference between the mean hepatic and splenic attenuation) was <5 Hounsfield Units.
RESULTS: In subjects with diabetes (n = 282), 25(OH)D levels were negatively associated with waist circumference, fasting insulin, HOMA-IR, triglyceride levels, and visceral abdominal fat, and were positively associated with LAI after adjusting for age, sex, season, exercise, and vitamin supplementation. In subjects without diabetes, only triglyceride level was negatively associated with 25(OH)D. The adjusted odds ratio (OR) for NAFLD increased sequentially across decreasing quartiles of 25(OH)D in subjects with diabetes even after adjusting for visceral fat [Q1 vs. Q4; OR for NAFLD 2.5 (95% CI:1.0-6.2)]. In contrast, no significant difference in OR was observed in subjects without diabetes. When we classified non-diabetic subjects by HOMA-IR, an increase in the OR for NAFLD across decreasing quartiles of 25(OH)D was observed in the high HOMA-IR (≥2.5) group [n = 207, Q1 vs. Q4; OR 3.8(1.4-10.3)], but not in the low HOMA-IR (<2.5) group [n = 592, OR 0.8 (0.3-1.9)].
CONCLUSIONS: Low vitamin D status is closely associated with NAFLD, independent of visceral obesity in subjects with diabetes or insulin resistance.
Liver attenuation Index: Diabetic
PMID: 24130687
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See also Vitamin D Life
- More fat in liver associated with lower vitamin D – June 2016
- Fatty liver disease weakly associated with low vitamin D – meta-analysis 2013
- Fatty liver disease (NAFLD) and the importance of vitamin D – Oct 2012
- Half of obese children had fatty liver and low vitamin D – March 2014
- Search for Fatty Liver in Vitamin D Life 316 items July 2017
- Strong association of non alcoholic fatty liver disease and low vitamin D
- Non-alcoholic Fatty Liver Disease (4 in 10 seniors) and Vitamin D
- Vitamin C reduces liver inflammation, which improves vitamin D production – Dec 2014
- Non-alcoholic fatty liver disease associated with low vitamin D – independent of BMI – June 2014
See also web
- Ask Well: Diagnosing Fatty Liver NYT June 2014