Adherence to dietary guidelines and risk of dementia: a prospective cohort study of 94 184 individuals
Epidemiology and Psychiatric Sciences , Volume 31 , 2022 , e71 DOI: https://doi.org/10.1017/S2045796022000567
E. W. Kjeldsen J. Q. Thomassen, K. L. Rasmussen, B. G. Nordestgaard, A. Tybjærg-Hansen and. Frikke-Schmidt
Aims
Recent estimates suggest that 40% of dementia cases could be avoided by treating recognised cardiovascular risk factors such as hypertension, diabetes, smoking and physical inactivity. Whether diet is associated with dementia remains largely unknown. We tested if low adherence to established dietary guidelines is associated with elevated lipids and lipoproteins and with increased risk of Alzheimer's disease and non-Alzheimer's dementia – a dementia subtype with a high frequency of cardiovascular risk factors.
Methods
We used the prospective Copenhagen General Population Study including 94 184 individuals with dietary information and free of dementia at baseline. Mean age at study entry was 58 years, and 55% (N = 51 720) were women and 45% (N = 42 464) were men. Adherence to dietary guidelines was grouped into low, intermediate and high adherence based on food frequency questionnaires. Main outcomes were non-Alzheimer's dementia and Alzheimer's disease.
Results
Low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol and plasma triglyceride levels were higher in individuals with intermediate and low adherence to dietary guidelines compared with individuals with high adherence (all p for trends <0.001). Age and sex-adjusted hazard ratios (HRs) for non-Alzheimer's dementia v. individuals with high adherence were 1.19 (95% confidence interval 0.97–1.46) for intermediate adherence, and 1.54 (1.18–2.00) for low adherence. Corresponding HRs in multivariable-adjusted models including APOE genotype were 1.14 (0.92–1.40) and 1.35 (1.03–1.79). These relationships were not observed in individuals on lipid-lowering therapy.
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Vitamin D Life pages with DEMENTIA in title (45 as of Oct 2022)
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Items found: 57
| Title | | Modified |
| Vitamin D deficiency increases risk of Dementia by 1.4 X and Alzheimer’s by 1.5 X – Meta-analysis March 2024 | | 11 Mar, 2024 |
| Early-Onset Dementia 1.6X more likely if low Vitamin D - Dec 2023 | | 12 Jan, 2024 |
| Dementia (vascular) risk increase 60% if take Folate with other B vitamins - Dec 2023 | | 16 Dec, 2023 |
| The End of Alzheimer's and Dementia if adjust Vitamin D, B-12, Iron, Omega-3, etc. | | 19 Aug, 2023 |
| Seniors taking vitamin D were 40% less likely to get dementia - Jan 2023 | | 28 Jul, 2023 |
| Poor bone health is a ‘robust’ dementia risk factor (both associated with Low vitamin D) - March 2023 | | 31 Mar, 2023 |
| Dementia 2.6 X more likely if very low Vitamin D – March 2023 | | 19 Mar, 2023 |
| The Role of Vitamin D in Reducing Risk of Alzheimer’s and Dementia - transcript Dr. Grant March 2023 | | 12 Mar, 2023 |
| Dementia again associated with low Vitamin D – 15th study in 10 years – Jan 2023 | | 03 Mar, 2023 |
| Neurodegenerative diseases (AD, PD, MS, Dementia, etc.) fought by Vitamin D (in rodents) – Jan 2023 | | 24 Feb, 2023 |
| How Vitamin D fights neurodegeneration (Multiple Sclerosis, Alzheimer’s, Dementia, etc) – Jan 2023 | | 12 Jan, 2023 |
| Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022 | | 06 Jan, 2023 |
| Dementia is associated with low vitamin D - many studies | | 02 Jan, 2023 |
| Dementia 1.35 X more-likely if poor diet – Oct 2022 | | 13 Oct, 2022 |
| Doggie dementia 6.5X more likely if not get exercise (probably low vitamin D) - Aug 2022 | | 27 Aug, 2022 |
| Dementia 2X more likely after ICU (suspect low Vitamin D) - Aug 2022 | | 02 Aug, 2022 |
| Calcitriol (activated Vitamin D) increases dementia (however, regular D decreases it) – June 2022 | | 13 Jul, 2022 |
| Vitamin Supplementation and Dementia - Review May 2022 | | 11 May, 2022 |
| Lewy Body Dementia (Robin Williams) and low Vitamin D | | 11 May, 2022 |
| Dementia 10X lower in a group who are outdoors a lot and eat unprocessed foods - March 2022 | | 07 Apr, 2022 |
| Mild cognitive impairment is 3X more likely to become dementia in one year if low vitamin D – March 2022 | | 07 Apr, 2022 |
| Dementia 1.7X higher risk if diabetic and low vitamin D - Jan 2022 | | 14 Feb, 2022 |
| Dementia 4.1 X high risk in those with low Vitamin D, Omega-3, etc.2 decades before (behind paywall) – Nov 2021 | | 22 Nov, 2021 |
| Dementia reduced 26 percent after pollution was reduced a decade earlier (probably higher Vitamin D) – Aug 2021 | | 19 Aug, 2021 |
| Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020 | | 08 Jan, 2021 |
| The Evidence is strong: Air pollution seems to cause dementia (perhaps low Vitamin D) – May 2019 | | 09 May, 2019 |
| Vitamin or Mineral Supplements Don’t Prevent Dementia (only one Vitamin D trial, it used 400 IU) – Feb 2019 | | 04 Feb, 2019 |
| Treating herpes reduced incidence of senile dementia by 10 X (HSV1 reduces VDR by 8X) – 2018 | | 17 Jan, 2019 |
| Why dementia gets more severe in the winter – Jan 2019 | | 14 Jan, 2019 |
| Vitamin D and neurological diseases such as stroke, Vascular Dementia, PD, MS - July 2018 | | 07 Dec, 2018 |
| Osteoporosis in men increased their risk of Dementia by 1.3 (60,000 Germans) – July 2018 | | 21 Aug, 2018 |
| Dementia – clinical trial using 4,000 IU of Vitamin D– 2023 | | 02 Aug, 2018 |
| Dementia risk increased 2.4 X following TBI, even if had not lost consciousness – May 2018 | | 12 May, 2018 |
| Dementia less likely with increased levels of Magnesium etc. | | 18 Apr, 2018 |
| 5 Traumatic brain injuries resulted in 2.8 X increased risk of dementia – April 2018 | | 11 Apr, 2018 |
| Off Topic: Dementia risk reduced 90 percent if woman had been highly fit 40 years before | | 18 Mar, 2018 |
| Risk of Dementia and Alzheimer's reduced by higher levels of Vitamin D – meta-analysis Feb 2018 | | 16 Feb, 2018 |
| Should you have a dementia advanced directive - Jan 2018 | | 19 Jan, 2018 |
| Dementia risk reduced 29 percent by just 10 hours of computer brain plasticity training – RCT Dec 2017 | | 08 Dec, 2017 |
| Vitamin D and Multiple Sclerosis, Alzheimer's, Parkinson's ,Dementia, and ALS - review Nov 2017 | | 23 Nov, 2017 |
| Heart Attack increased risk of vascular dementia by 1.35 X (both associated with low vitamin D) Oct 2017 | | 15 Nov, 2017 |
| Dementia risk factor is increased by 1.5 if low vitamin D – meta-analysis Jan 2017 | | 15 Jan, 2017 |
| Dementia 19X more likely if low vitamin D – Jan 2012 | | 27 Oct, 2016 |
| The "Surprising Link" Between Vitamin D Deficiency and Dementia (nope) - Oct 2015 | | 04 Oct, 2016 |
| The "Surprising Link" Between Vitamin D Deficiency and Dementia (not a surprise) - Oct 2015 | | 04 Oct, 2016 |
| Dementia risk significantly increased if have 4 chronic diseases – all associated with low vitamin D – Sept 2015 | | 11 Dec, 2015 |
| Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015 | | 01 Nov, 2015 |
| Dementia surprisingly associated with low vitamin D (should not a surprise) – Aug 2014 | | 03 Oct, 2015 |
| Dementia 13X more likely in elderly with low vitamin D – May 2014 | | 04 Sep, 2015 |
| Dementia risk increases with latitude (less vitamin D) - Feb 2015 | | 20 Feb, 2015 |
Note: Probably 1.5 X less-likely to get dementia if vitamin D >20 ng