Computational and Mathematical Methods in Medicine 2022 https://doi.org/10.1155/2022/2910782
Huan Yang ,1 Deyang Sun ,1 Fengqing Wu,2 Xiao Xu,2 Xi Liu,2 Zhen Wang ,3 and Linshui Zhou 3
Even with huge differences in dose size, type, and time COPD was, in net, still helped
Background. Many studies have demonstrated that vitamin D has clinical benefits when used to treat patients with chronic obstructive pulmonary disease (COPD). However, most of these studies have insufficient samples or inconsistent results. The aim of this meta-analysis was to evaluate the effects of vitamin D therapy in patients with COPD.
Methods. We performed a comprehensive retrieval in the following electronic databases: PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data, and Chinese Scientific Journals Database (VIP). Two trained reviewers identified relevant studies, extracted data information, and then assessed the methodical quality by the Cochrane risk of bias assessment tool, independently. Then, the meta-analyses were conducted by RevMan 5.4, binary variables were represented by risks ratio (RR), and continuous variables were represented by mean difference (MD) or standardized mean difference (SMD) to assess the efficacy of vitamin D therapy in patients with COPD. Then, publication bias assessment was conducted by funnel plot analysis. Finally, the quality of evidence was assessed by the GRADE system.
Results. A total of 15 articles involving 1598 participants were included in this study. The overall results showed a statistical significance of vitamin D therapy in patients with COPD which can significantly improve forced expiratory volume in 1 second (FEV1) (MD: 5.69, 95% CI: 5.01-6.38,,) and FEV1/FVC (SMD:0.49, 95% CI: 0.39-0.60,,); and serum 25 (OH)D (SMD:1.21, 95% CI:1.07-1.34,,) also increase CD3+ Tcells (MD: 6.67, 95% CI: 5.34-8.00,,) and CD4+ T cells (MD: 6.00, 95% CI: 5.01-7.00,,); and T lymphocyte CD4+/CD8+ ratio (MD: 0.41, 95% CI: 0.20-0.61,,) obviously decrease CD8+ Tcells(SMD: -0.83, 95% CI: -1.05- -0.06,,), the times of acute exacerbation (RR: 0.40, 95% CI: 0.28-0.59,,), and COPD assessment test (CAT) score (MD: -3.77, 95% CI: -5.86 - -1.68,,).
Conclusions. Our analysis indicated that vitamin D used in patients with COPD could improve the lung function (FEV1 and FEV1/FVC), the serum 25(OH)D, CD3+ T cells, CD4 + T cells, and T lymphocyte CD4+/CD8+ ratio and reduce CD8+ T cells, acute exacerbation, and CAT scores.
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Note: Inhaled vitamin D was observed to also help COPD
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Vitamin D Life pages with COPD in title
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| Title | | Modified |
| COPD fought by Vitamin D - many studies | | 23 Oct, 2023 |
| The Sun is the best remedy for Your Lungs (Infection, Asthma and COPD) - video June 2022 | | 27 Jun, 2022 |
| COPD treated by Vitamin D – meta-analysis March 2022 | | 12 Mar, 2022 |
| Sarcopenia with obesity is more likely if dark skin, diabetes, OR COPD (all associated with low vitamin D) | | 16 Oct, 2021 |
| Asthma and COPD in a few seniors greatly decreased by monthly 100,000 IU Vitamin D – RCT Feb 2021 | | 28 Jun, 2021 |
| High PTH plus low Vitamin D is not good (5X more likely for COPD to need hospital) – April 2021 | | 25 Apr, 2021 |
| Vitamin D is one of the alternate COPD therapies – March 2021 | | 04 Apr, 2021 |
| COPD trial to use 80,000 IU of vitamin D weekly – RCT 2021 | | 19 Mar, 2020 |
| Those with Asthma or COPD had half the response to Vitamin D – March 2020 | | 19 Mar, 2020 |
| COPD increases risk of bone fracture by 4.7 X (low vitamin D) – Dec 2019 | | 08 Dec, 2019 |
| Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019 | | 26 Nov, 2019 |
| Smoke Inflammation reduced by vitamin D (COPD in lab) – Sept 2019 | | 06 Sep, 2019 |
| COPD quality of life improved by 400,000 IU Vitamin D loading dose – RCT July 2019 | | 08 Jul, 2019 |
| COPD in Asians twice as likely if poor Vitamin D Binding Protein – meta-analysis May 2019 | | 16 Jun, 2019 |
| COPD flare-ups reduced 40 percent by Vitamin D in those who were deficient – May 2019 | | 24 May, 2019 |
| COPD results in bone loss and osteopenia, Vitamin D should reduce both – May 2019 | | 16 May, 2019 |
| COPD severity is associated with Vitamin D deficiency – meta-analyses 2015, 2019 | | 17 Mar, 2019 |
| COPD exacerbations 2X less often if low vitamin D then supplemented – meta-analysis Jan 2019 | | 15 Jan, 2019 |
| COPD 2.8 times more likely to be severe if low vitamin D – meta-analysis Oct 2016 | | 13 Sep, 2018 |
| COPD with obstruction: Death 1.7 X more likely with low vitamin D – Sept 2018 | | 13 Sep, 2018 |
| Worse breathing with COPD is related to lower Vitamin D – June 2018 | | 01 Jul, 2018 |
| Hypothesis – Use of anticoagulants with COPD lowers Vitamin K, which increases calcification – Nov 2017 | | 25 Jan, 2018 |
| COPD strongly associated with Vitamin D Binding Protein problems – meta-analysis Aug 2015 | | 12 Jun, 2017 |
| COPD ICU stay is 2.4 days longer if low vitamin D – Oct 2015 | | 12 May, 2017 |
| COPD and Vitamin D, concise (46 page) review – Dec 2016 | | 07 Dec, 2016 |
| COPD is associated with several other diseases (comorbidities) – July 2016 | | 10 Oct, 2016 |
| COPD reduced by 40 percent with monthly 100,000 IU of vitamin D – RCT Jan 2015 | | 17 Sep, 2016 |
| COPD, Osteoporosis, and low Vitamin D – Sept 2016 | | 14 Sep, 2016 |
| COPD strongly associated with Vitamin D receptor problems – meta-analysis Aug 2015 | | 01 Dec, 2015 |
| Gene makes COPD 2.6X more likely unless get more vitamin D – meta-analysis Dec 2014 | | 04 Nov, 2015 |
| Danes opposed to Vitamin D fortification, will get more COPD, diabetes, depression, lupus, leg pain, etc – Oct 2015 | | 31 Oct, 2015 |
| Vitamin D loading dose then weekly 50,000 IU not help (COPD) if very deficient – Oct 2015 | | 16 Oct, 2015 |
| Asthma with COPD has lower vitamin D levels than asthma alone – Sept 2015 | | 25 Sep, 2015 |
| 2.8X higher risk of osteoporosis if COPD and modified vitamin D receptor genes – Sept 2015 | | 09 Sep, 2015 |
| COPD 2.6X more likely if poor vitamin D binding protein – meta-analysis Dec 2014 | | 27 Aug, 2015 |
| COPD – almost all women in Bulgaria hospitalized with COPD had low vitamin D – June 2015 | | 06 Jun, 2015 |
| COPD reduced by vitamin D taken once every 60 days – RCT Dec 2014 | | 03 Jun, 2015 |
| COPD getting worse is associated with very low vitamin D – March 2015 | | 03 Jun, 2015 |
| Magnesium is associated with better quality of life in COPD, not Vitamin D – March 2015 | | 13 May, 2015 |
| COPD becoming suddenly worse is 30X more likely if low vitamin D – Dec 2014 | | 13 Mar, 2015 |
| Vitamin D treats COPD thru many pathways – March 2015 | | 13 Mar, 2015 |
| COPD and vitamin D in a vicious circle – April 2011 | | 24 Jan, 2015 |
| 100000 IU vitamin D monthly helps COPD patients – 3 RCT | | 20 Jan, 2015 |
| 100000 IU vitamin D monthly helped COPD patients – 2011 and 2012 | | 20 Jan, 2015 |
| COPD 2.6X more likely if alteration in a Vitamin D gene (1F-1F ) – meta-analysis Dec 2014 | | 18 Jan, 2015 |
| Vitamin D Binding Protein, And Airflow In COPD - April 2012 | | 21 Dec, 2014 |
| COPD 2.6X more likely if poor vitamin D binding protein – Dec 2014 | | 13 Dec, 2014 |
| Genetic link found between vitamin D and COPD – June 2010 | | 10 Dec, 2014 |
| COPD helped by weekly 50,000 IU Vitamin D – Aug 2013 | | 03 May, 2014 |
| COPD lung volume reduction strongly associated with low vitamin D – March 2014 | | 19 Mar, 2014 |
| Asthma is strongly associated with low vitamin D (but not COPD) – meta-analysis Feb 2014 | | 17 Mar, 2014 |
| COPD 2X as likely if low vitamin D – review of 3 studies – March 2014 | | 11 Mar, 2014 |
| The worse the COPD the lower the levels of vitamin D – Aug 2012 | | 28 Feb, 2014 |
| Lung, lung cancer, asthma, COPD, and Vitamin D – July 2013 | | 22 Feb, 2014 |
| COPD reduce 2X if severely deficient and treated with 3,300 IU daily average of vitamin D – Jan 2012 | | 15 Jun, 2013 |
| COPD – Bone Metabolism – Osteoporosis – Vitamin D appear related – Mar 2011 | | 02 May, 2013 |
| COPD and Osteoporosis are related – vitamin D is one possible connection – 2013 | | 02 May, 2013 |
| COPD patients 4X more likely to have low Vitamin D – 2 articles in 2012 | | 01 Nov, 2012 |
| Less COPD if vitamin D more than 30 ng – Nov 2011 | | 28 Sep, 2012 |
| Vitamin D deficiency is highly prevalent in COPD - 2010 | | 05 Nov, 2011 |