Large Meta-Analysis in the CHARGE Consortium Provides Evidence For an Association of Serum Vitamin D With Pulmonary Function
bioRxiv doi: https://doi.org/10.1101/144717
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The Meta-analysis of BREATHING and Vitamin D
- Acute viral respiratory infections reduced by Vitamin D - overview of 20 reviews - Aug 2020
- Asthmatics less able to breathe if low vitamin D – meta-analysis Nov 2019
- Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019
- Pneumonia 6X more likely if very low vitamin D – meta-analysis Sept 2019
- Asthma supplementation by Vitamin D (any amount) reduced attacks by 25 percent – meta-analysis April 2019
- Respiratory infections reduced only 20 percent by Vitamin D (ignored dose size, duration, type, etc) – meta-analysis Jan 2019
- Breath better if higher level of Vitamin D – meta-analysis March 2018
- Asthma risk reduced by 67 percent with Vitamin D supplementation if level was initially low– meta-analysis Nov 2017
- Pneumonia patients 3 X more likely to die if low vitamin D – meta-analysis Sept 2017
- Acute respiratory tract infections prevented by vitamin D (even when ignoring the dose size – Meta-analysis Feb 2017
- Asthma exacerbations in children decrease by 60 percent with vitamin D supplementation – meta-analysis – 2015
- Vitamin D during pregnancy reduces risk of childhood asthma by 13 percent – meta-analysis Dec 2016
- Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016
- COPD 2.8 times more likely to be severe if low vitamin D – meta-analysis Oct 2016
- Lower respiratory tract infections in children associated with Low Vitamin D – meta-analysis May 2016
- Asthma medicines not helped by vitamin D (if only a small amount of D is taken) – meta-analysis Dec 2015
- Asthma not helped by less than 2,000 IU of vitamin D - meta-analysis Aug 2015
- COPD strongly associated with Vitamin D Binding Protein problems – meta-analysis Aug 2015
- COPD severity is associated with Vitamin D deficiency – meta-analyses 2015, 2019
- Infant wheezing 40 percent less likely if mother supplemented with vitamin D, vitamin E, or Zinc – meta-analysis Aug 2015
- Gene makes COPD 2.6X more likely unless get more vitamin D – meta-analysis Dec 2014
- Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015
- Acute Lower Respiratory Infections in Children - associated with low vitamin D – meta-analysis Dec 2014
- Asthma is strongly associated with low vitamin D (but not COPD) – meta-analysis Feb 2014
- Vitamin D and Respiratory Tract Infections – meta-analysis with charts June 2013
- Vitamin D reduces respiratory tract infections by 40 percent– meta-analysis Dec 2012
- Acute respiratory infection treated by vitamin D in 6 of 12 clinical trials – review Nov 2012
Breathing category starts with the following
- Search Vitamin D Life for Pneumonia 1,360 items as of July 2019
- Search Vitamin D Life for phrase "COMMUNITY PNEUMONIA" 99 items - Jan 2020
- Search Vitamin D Life for BRONCHITIS 272 items as of July 2019
- Search Vitamin D Life for ASTHMA in title 142 items - Nov 2019
- COPD Overview
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41 items along with related searches - Air Pollution reduces Vitamin D
- Note: Air Pollution reduces UVB and keeps people indoors, both reduce Vitamin D
- Smoking reduces vitamin D
Supplementing with Vitamin D will improve the health of smokers and might decease craving- Overviews at Vitamin D Life:
Allergy Lung Cancer TB Asthma Influenza Colds and flu Pneumonia Respiratory infectionsBREATHING and Vitamin D Intervention studies
- Those with Asthma or COPD had half the response to Vitamin D – March 2020
- Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020
- Hay Fever treated by Vitamin D (50,000 IU weekly) – RCT July 2019
- COPD trial to use 80,000 IU of vitamin D weekly – RCT 2021
- Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019
- Childhood colds reduced 25 percent by weekly Vitamin D – RCT Jan 2019
- All asthma problems reduced after 1 year of Vitamin D – Nov 2017
- Asthma treated by daily 50,000 IU of Vitamin D – April 2018
- Childhood Respiratory Health hardly improved with 600 IU of vitamin D (need much more) – May 2018
- Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT Jan 2018
- Influenza risk reduced 2X by 2,000 IU of Vitamin D (vs 400), RTI reduced 3X by 400 or more IU – July 2017
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Reduction of infant asthma may require good vitamin D when lung development starts (4 weeks) – March 2017
- Monthly 100,000 IU of vitamin D decreased respiratory infection but increased falls – Nov 2016
- RTI – Feel much better if increase vitamin D level above 40 ng (4000 IU) – RCT Sept 2015
- Five times less mite allergy when vitamin D added in mid pregnancy and to infant – RCT April 2016
- Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
- Asthma exacerbations with colds reduced by 40 percent with vitamin D supplementation – Nov 2015
- Allergic Rhinitis (hay fever) reduced by just 1,000 IU of vitamin D for 30 days – RCT Sept 2015
- Vitamin D loading dose then weekly 50,000 IU not help (COPD) if very deficient – Oct 2015
- Respiratory tract infection eliminated in 36 percent of people by 4000 IU of Vitamin D – RCT Sept 2015
- COPD reduced by 40 percent with monthly 100,000 IU of vitamin D – RCT Jan 2015
- 500,000 IU of vitamin D cut in half the hospital days following a lung failure – RCT 2015
- Respiratory infections cut in half by 20,000 IU weekly vitamin D if initially deficient – RCT March 2015
- Wheezing reduced 35 percent if vitamin D added during pregnancy – April 2015
- 5 days of 100,000 IU of Vitamin D increased hemoglobin in critical illness – RCT April 2015
- Respiratory diseases helped by vitamin D if initially have low level – RCT review Jan 2015
- COPD reduced by vitamin D taken once every 60 days – RCT Dec 2014
- Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015
- Respiratory Tract visits 2.5 less likely with vitamin D: Pregnancy 2000 IU, Infant 800 IU – RCT Oct 2014
- Allergy to House dust mite greatly reduced by adding just 600 IU of vitamin D – RCT Nov 2014
- Asthma reduced by weekly 50,000 IU of vitamin D – RCT Aug 2014
- Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014
- 2000 IU of vitamin D should improve toddlers health in winter – RCT almost completed Feb 2014
- Bronchial Asthma reduced with 60,000 IU monthly vitamin D – RCT Nov 2013
- COPD Overview
- Respiratory infections reduced by 63 percent with 4000 IU vitamin D daily - RCT Dec 2012
- Just 300 IU daily of vitamin D reduced respiratory infections by 50% – RCT Aug 2012
- Recurrence of child pneumonia delayed by 100000 IU of vitamin D – RCT Oct 2010
- 100000 IU vitamin D monthly helps COPD patients – 3 RCT
 Download the preprint PDF from Vitamin D Life
Jiayi Xu, Traci M. Bartz, Geetha Chittoor, Gudny Eiriksdottir, Ani W. Manichaikul, Fangui Sun, Natalie Terzikhan, Xia Zhou, Sarah L. Booth, Guy G. Brusselle, Ian H. de Boer, Myriam Fornage, Alexis C. Frazier-Wood, Mariaelisa Graff, Vilmundur Gudnason, Tamara B. Harris, Albert Hofman, Ruixue Hou, Denise K. Houston, David R. Jacobs Jr., Stephen B. Kritchevsky, Jeanne Latourelle, Rozenn N. Lemaitre, Pamela L. Lutsey, George O'Connor, Elizabeth C. Oelsner, James S. Pankow, Bruce M. Psaty, Rebecca R. Rohde, Stephen S. Rich, Jerome I. Rotter, Lewis J. Smith, Bruno H. Stricker, V. Saroja Voruganti, Thomas J. Wang, M. Carola Zillikens, R. Graham Barr, Josée Dupuis, Sina A. Gharib, Lies Lahousse, Stephanie J. London, Kari E. North, Albert V. Smith, Lyn M. Steffen, Dana B. Hancock, Patricia A. Cassano
The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for the association of serum 25-hydroxyvitamin D [25(OH)D] and pulmonary function. We conducted the largest cross-sectional meta-analysis of the 25(OH)D-pulmonary function association to date, based on nine European ancestry (EA) cohorts (n=22,838) and five African ancestry (AA) cohorts (n=4,290) in the CHARGE Consortium. Data were analyzed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean (SD) serum 25(OH)D was 68 (29) nmol/L for EAs and 49 (21) nmol/L for Aas.
For each 1 nmol/L higher 25(OH)D, forced expiratory volume in the first second (FEV1) was higher by 1.1 mL in EAs (95% CI: 0.9,1.3; P=2.5×10-21) and 1.8 mL (95% CI: 1.1,2.5; P=1.6×10-7) in AAs (Prace difference=0.06), and forced vital capacity (FVC) was higher by 1.3 mL in EAs (95% CI: 1.0,1.6; P=1.1×10-20) and 1.5 mL (95% CI: 0.8,2.3; P=1.2×10-4) in AAs (Prace difference=0.56).
Among EAs, the 25(OH)D-FVC association was stronger in smokers: per 1nmol/L higher 25(OH)D, FVC was higher by 1.7 mL (95% CI: 1.1,2.3) for current smokers and 1.7 mL (95% CI: 1.2,2.1) for former smokers, compared to 0.8 mL (95% CI: 0.4,1.2) for never smokers. In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EAs, a stronger association was observed for smokers compared to never smokers, which supports the importance of vitamin D in vulnerable populations.Breath better if higher level of Vitamin D – meta-analysis March 20181331 visitors, last modified 13 Mar, 2018, - Air Pollution reduces Vitamin D