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Blotchy skin in seniors (Bateman purpura or dermatoporosis) treated by topical vitamin C, etc. – RCT Aug 2017

Bateman purpura (dermatoporosis): a localized scurvy treated by topical vitamin C – Double blind randomized placebo-controlled clinical trial

J. of the European Academy of Dermatology . . online: 17 August 2017, DOI: 10.1111/jdv.14525
P. Humbert, F. Fanian, T. Lihoreau, A. Jeudy, G.E. Pierard

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Background
Bateman purpura is characterized by diffuse senile skin atrophy, senile purpura and spontaneous stellar pseudo-cicatrices. Cutaneous changes in the course of aging have been related to lower levels of ascorbic acid into the dermis of elderly people.

Objective
In the present study, we postulate that senile purpura could be linked to dermal vitamin C deficiency and could be corrected by topical administration of this vitamin.

Methods
A 12-weeks, hemi-member (forearm or leg), randomized double-blind comparative study, was conducted in 18 patients with Bateman purpura aged over than 60 years. At each visit, clinical assessment and biometrological measurements were performed. Clinical examination and scoring by experts showed a significant improvement on the vitamin C-treated side compared with the control, with reduction of hemorrhage areas, increase of dermal thickness.

Results
Twice-daily application of 5% topical vitamin C led to a clinically apparent improvement of the skin symptoms and allows beneficial effects on skin elasticity and thickness. Bateman purpura, a classical sign of photoaging whose origin has not clearly been recognized could be improved by vitamin C applied on to the skin.

Conclusion
These results confirm the hypothesis of underlying of role vitamin C deficiency in the determinism of Bateman purpura.


Created by admin. Last Modification: Wednesday November 22, 2017 02:46:05 GMT-0000 by admin. (Version 3)

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