Meta-analysis of vitamin D and lung function in patients with asthma
Respiratory Research 20, 161 doi:10.1186/s12931-019-1072-4
Jian Liu, Yong-Quan Dong, Jie Yin, Jian Yao, Jie Shen, Guo-Jie Sheng, Kun Li, Hai-Feng Lv, Xing Fang & Wei-Fang Wu
- Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018
- Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
- Adult-onset asthma 2X more likely if low vitamin D and not hyperallergenic – May 2018
- Vitamin D supplements could halve risk of serious asthma attacks – Cochrane conclusion – Sept 2016
- Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Proof that Vitamin D Works 86 health problems prevented/treated as of May 2018
Asthma has been proven to be treated by Vitamin D in at least 4 random controlled trials - Women with asthma 35X more likely to be vitamin D deficient – Oct 2013
Meta-Analyses
- Asthmatics less able to breathe if low vitamin D – meta-analysis Nov 2019
- Asthma supplementation by Vitamin D (any amount) reduced attacks by 25 percent – meta-analysis April 2019
- Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015
- Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016
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Background
There is growing literature suggesting a link between vitamin D and asthma lung function, but the results from systematic reviews are conflicting. We conducted this meta-analysis to investigate the relation between serum vitamin D and lung function in asthma patients.Methods
Major databases, including OVID, MEDLINE, Web of Science and PUBMED, were searched until 10th October 2018. All published observational studies related to vitamin D and asthma were extracted. All meta-analyses were performed using Review Manager 5.3.5.Results
This quantitative synthesis found that asthma patients with low vitamin D levels had lower forced expiratory volume In 1 s (FEV1) (mean difference (MD) = − 0.1, 95% CI = − 0.11 to − 0.08,p < 0.01;I2 = 49%, p = 0.12) and FEV1% (MD = − 10.02, 95% CI = − 11 to − 9.04, p < 0.01; I2 = 0%, p = 0.82) than those with sufficient vitamin D levels. A positive relation was found between vitamin D and FEV1 (r = 0.12, 95% CI = 0.04 to 0.2, p = 0.003; I2 = 59%,p = 0.01), FEV1% (r = 0.19, 95% CI = 0.13 to 0.26, p < 0.001; I2 = 42%, p = 0.11), forced vital capacity (FVC) (r = 0.17, 95% CI = 0.00 to 0.34, p = 0.05; I2 = 60%, p = 0.04), FEV1/FVC (r = 0.4, 95% CI = 0.3 to 0.51, p < 0.001; I2 = 48%, p = 0.07), and the asthma control test (ACT) (r = 0.33, 95% CI = 0.2 to 0.47, p < 0.001; I2 = 0%, p = 0.7). Subgroup analysis indicated that the positive correlation between vitamin D and lung function remained significant in both children and adults.Conclusions
Our meta-analysis suggested that serum vitamin D levels may be positively correlated with lung function in asthma patients. Future comprehensive studies are required to confirm these relations and to elucidate potential mechanisms.Asthmatics less able to breathe if low vitamin D – meta-analysis Nov 2019Printer Friendly PDF this page! Follow this page for updates604 visitors, last modified 14 Nov, 2019, This page is in the following categories (# of items in each category) - Air Pollution reduces Vitamin D