Randomized trial of three doses of vitamin D to reduce deficiency in pregnant Mongolian women
EBioMed - Lancet - DOI: https://doi.org/10.1016/j.ebiom.2018.11.060
D. Enkhmaa, L. Tanz, D. Ganmaa, Sh. Enkhtur, B. Oyun-Erdene, J. Stuart, G. Chen, A. Carr, E.W. Seely, G. Fitzmaurice, Yo. Buyandelger, B. Sarantsetseg, G. Gantsetseg, J. Rich-Edwards
88% of the women got >80% of the vitamin D
Many other studies have found far higher compliance
with weekly or bi-weekly doses instead of daily
Note: Very low levels to start with: 91% < 20 ng
4,000 IU of Vitamin D is OK - 19 organizations agree - 2018
Pregnancy category starts with
- see also
- Overview Pregnancy and vitamin D
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- Healthy pregnancies need lots of vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception
The trial on this page started a Vitamin D maintenance dose at 12-16 weeks.
Far far better to fully restore the Vitamin D at 2 weeks,
or start maintenace dose before conceptionHealthy pregnancies need lots of vitamin D has the following summary
ProblemReduces Evidence 0. Chance of not conceiving 3.4 times Observe 1. Miscarriage 2.5 times Observe 2. Pre-eclampsia 3.6 times RCT 3. Gestational Diabetes 3 times RCT 4. Good 2nd trimester sleep quality 3.5 times Observe 5. Premature birth 2 times RCT 6. C-section - unplanned 1.6 times Observe Stillbirth - OMEGA-3 4 times RCT - Omega-3 7. Depression AFTER pregnancy 1.4 times RCT 8. Small for Gestational Age 1.6 times meta-analysis 9. Infant height, weight, head size
within normal limitsRCT 10. Childhood Wheezing 1.3 times RCT 11. Additional child is Autistic 4 times Intervention 12.Young adult Multiple Sclerosis 1.9 times Observe 13. Preeclampsia in young adult 3.5 times RCT 14. Good motor skills @ age 3 1.4 times Observe 15. Childhood Mite allergy 5 times RCT 16. Childhood Respiratory Tract visits 2.5 times RCT RCT = Randomized Controlled Trial
Download the PDF from Vitamin D Life
MothersUmbilical Cord
Background: In winter in Mongolia, 80% of adults have 25-hydroxyvitamin D (25(OH)D) concentrations <25 nmol/l (<10 ng/ml) and 99% have <50 nmol/l (<20 ng/ml). The vitamin D dose to avert deficiency during pregnancy in this population is unknown.
Methods
We conducted a randomized, controlled, double-blind trial of daily 600, 2000, or 4000 IU vitamin D3 for pregnant women in Mongolia (Clinicaltrials.gov #NCT02395081). We examined 25(OH)D concentrations at baseline (12–16 weeks' gestation), 36–40 weeks' gestation and in umbilical cord blood, using enzyme linked fluorescent assay. Sample size was determined to detect 0.4 standard deviation differences in 25(OH)D concentrations with 80% power.Findings
119 pregnant women were assigned 600 IU, 121 assigned 2000 IU and 120 assigned 4000 IU from February 2015 through December 2016. Eighty-eight percent of participants took ≥80% of assigned supplements. At baseline, 25(OH)D concentrations were similar across arms; overall mean ± standard deviation concentration was 19 ± 22 nmol/l; 91% were < 50 nmol/l.
At 36–40 weeks, 25(OH)D concentrations increased to 46 ± 21, 70 ± 23, and 81 ± 29 nmol/l for women assigned 600, 2000, and 4000 IU, respectively (p < 0.0001 across arms; p = 0.002 for 2000 vs. 4000 IU). Mean umbilical cord 25(OH)D concentrations differed by study arm (p < 0.0001 across arms; p < 0.0001 for 2000 vs. 4000 IU) and were proportional to maternal concentrations. There were no adverse events, including hypercalcemia, attributable to vitamin D supplementation.Interpretation
Daily supplementation of 4000 IU during pregnancy is safe and achieved higher maternal and neonatal 25(OH)D concentrations than 2000 IU. Daily 600 IU supplements are insufficient to prevent vitamin D deficiency in Mongolia.4,000 IU Vitamin D daily during pregnancy (Mongolia) was good – RCT Dec 2018(Cached) Printer Friendly PDF this page! Follow this page for updates1079 visitors, last modified 23 Oct, 2019, This page is in the following categories (# of items in each category)Pregnancy750 Attached files
ID Name Comment Uploaded Size Downloads 11035 Mongolian infant.jpg admin 13 Dec, 2018 20:34 18.42 Kb 192 11034 Mongolian mother.jpg admin 13 Dec, 2018 20:33 28.55 Kb 158 11033 Mongolian pregnancy RCT.pdf PDF 2018 admin 13 Dec, 2018 20:33 926.00 Kb 178 See any problem with this page? Report it (FINALLY WORKS) - All items in category Infant/Child